TITLE

Potentiometric Determination of Raloxifene by PVC Membrane Sensor

AUTHOR(S)
Ganjali, Mohammad Reza; Aghili, Sara; Pirali-Hamedani, Morteza; Norouzi, Parviz
PUB. DATE
November 2012
SOURCE
International Journal of Electrochemical Science;Nov2012, Vol. 7 Issue 11, p10394
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
PVC membrane potentiometric sensor was made for determination of raloxifene, an oral selective estrogen receptor modulator, in pharmaceutical formulations. The electrode respond based on ion-exchange mechanism. The ion-pair used as a sensing element in PVC membrane composition was synthesized through the interaction of raloxifene hydrochloride and sodium tetraphenyl borate. The best PVC membrane sensor response was obtained by a membrane composition of 30% PVC, 63% DBP, and 7% ion-pair. The detection limit of the constructed sensor was calculated 8.0x10-6 M. The proposed sensor has a fast response time (less than 10 s). The proposed method was successfully applied in determination of raloxifene in some pharmaceutical formulations.
ACCESSION #
83287770

 

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