Potentiometric Determination of Raloxifene by PVC Membrane Sensor

Ganjali, Mohammad Reza; Aghili, Sara; Pirali-Hamedani, Morteza; Norouzi, Parviz
November 2012
International Journal of Electrochemical Science;Nov2012, Vol. 7 Issue 11, p10394
Academic Journal
PVC membrane potentiometric sensor was made for determination of raloxifene, an oral selective estrogen receptor modulator, in pharmaceutical formulations. The electrode respond based on ion-exchange mechanism. The ion-pair used as a sensing element in PVC membrane composition was synthesized through the interaction of raloxifene hydrochloride and sodium tetraphenyl borate. The best PVC membrane sensor response was obtained by a membrane composition of 30% PVC, 63% DBP, and 7% ion-pair. The detection limit of the constructed sensor was calculated 8.0x10-6 M. The proposed sensor has a fast response time (less than 10 s). The proposed method was successfully applied in determination of raloxifene in some pharmaceutical formulations.


Related Articles

  • Nano-Composite Carbon Paste Electrode and PVC membrane Sensor for Potentiometric Determination of Erythromycin. Ganjali, Mohammad Reza; Pirzadeh-Naeeni, Shirin; Faridbod, Farnoush; Attar, Hosein; Hosseini, Morteza; Norouzi, Parviz // International Journal of Electrochemical Science;Jun2011, Vol. 6, p1968 

    In this work, two kinds of potentiometric sensor were introduced. Both sensors respond based on ion- exchange mechanism. Erythromycin-tetraphenyl borate ion-pair was employed as a sensing element in construction of both electrodes. First, PVC membrane electrode was made after series of...

  • Ion-selective electrode for the determination of dimethylbenzylammonium ions. Kopytin, A. V.; Urusov, Yu. I.; Zhukov, A. F.; Kokunov, Yu. V. // Journal of Analytical Chemistry;Jan2011, Vol. 66 Issue 1, p73 

    sensor is proposed for the direct potentiometric determination of dimethylbenzylammonium in acid and neutral aqueous solutions. The sensor membrane is made of a polymeric composition on the basis of polyvinylchloride containing an ion associate and a solvent as a plasticizer. Salts of the...

  • Ion-selective electrodes based on metalloporphyrins for gibberellic acid determination in agricultural products. Santos, Emília M. G.; Couto, Cristina M. C. M.; Montenegro, M. Conceição B. S. M.; Neves, M. Graça P. M. S.; Rebelo, Susana L. H.; Cavaleiro, J. A. S.; Reis, Boaventura F. // Analytical & Bioanalytical Chemistry;Feb2003, Vol. 375 Issue 4, p511 

    This work describes the construction, evaluation and analytical application of electrodes selective to the gibberellate anion for the determination of gibberellic acid in agricultural products. Several types of PVC membrane electrodes without internal reference solution were prepared using the...

  • Application of a New Tramadol Potentiometric Membrane Sensor as a Useful Device for Tramadol Hydrochloride Analysis in Pharmaceutical Formulation and Urine. Ganjali, Mohammad R.; Razavi, Taherehsadat; Faridbod, Farnoush; Riahi, Siavash; Norouzi, Parviz // Current Pharmaceutical Analysis;Feb2009, Vol. 5 Issue 1, p28 

    Tramadol, a 4-phenyl-piperidine analogue of codeine, is usually marketed as the hydrochloride salt and is a centrally acting analgesic, used for treating moderate to severe pain. In this study, a potentiometric liquid membrane sensors for simple and fast determination of tramadol hydrochloride...

  • Piribedil-Selective Electrodes Based on Bi(III)-Iodide and Hg(II)-Iodide Complexes. Abdel-Gawad, Fatama M.; Issa, Yousry M.; Hassouna, Mohamed E. M.; Hussien, Emad M. // Microchimica Acta;Jan2003, Vol. 141 Issue 1/2, p7 

    We describe new ion-selective electrodes for piribedil (PD) based on Bi(III)-iodide or Hg(II)-iodide piribedil ion associate complexes in a poly(vinyl chloride) (PVC) membrane with dibutylphthalate (DBP) and dioctylphthalate (DOP) as plasticizing solvent mediator. The electrodes (PD-[BiI4]/DBP,...

  • PVC MATRX IONIC - SURFACTANT SELECTIVE ELECTRODES BASED ON THE IONIC PAIR TETRA ALKYL-AMMONIUM - LAURYLSULPHATE. Mihali, Cristina; Oprea, Gabriela; Cical, Elena // Studia Universitatis Babes-Bolyai, Chemia;2009, Issue 3, p141 

    A series of all-solid-state electrodes sensible to the anionic surfactants were developed using silver pills coated with PVC membranes. We used cetyltrimethylammonium laurylsulfate (CTMA-LS) and tricaprylmethylammonium laurylsulfate (TCMA-LS) as electroactive matter (ionophore) and different...

  • Application of a trazodone-selective electrode to pharmaceutical quality control and urine analyses. García, M. Soledad; Ortuño, Joaquín; Albero, M. Isabel; Cuartero, María // Analytical & Bioanalytical Chemistry;Jul2009, Vol. 394 Issue 6, p1563 

    A trazodone-selective electrode for application in pharmaceutical quality control and urine analysis was developed. The electrode is based on incorporation of a trazodone-tetraphenylborate ion exchanger in a poly(vinyl chloride) membrane. The electrode showed a fast, stable and Nernstian...

  • Potentiometric sensors based on organic ion exchangers for determining tetraalkylammonium salts. Kulapina, E.; Makarova, N.; Bazhanova, L.; Pogorelova, E. // Journal of Analytical Chemistry;Jun2012, Vol. 67 Issue 6, p537 

    Potentiometric sensors with plasticized polymer membranes based on organic ion exchangers, tetraalkylammonium dodecyl sulfates (benzyldimethyldodecylammonium, benzyldimethyltetradecylammonium, dimethyldistearylammonium), have been proposed for the determination of quaternary ammonium salts in...

  • Electrocatalytic activity of copper alloys for NO reduction in a weakly alkaline solution. Mácová, Z.; Bouzek, K.; Šerák, J. // Journal of Applied Electrochemistry;May2007, Vol. 37 Issue 5, p557 

    A comparative study has been made of the influence of an addition of Sn to Cu as the basic cathode material on the electrocatalytic activity of the resulting material for nitrate (NO) reduction in a weakly alkaline medium. Potentiodynamic and chronoamperometric experiments were carried out in an...


Other Topics