July 2012
Asian Journal of Pharmaceutical & Clinical Research;Jul2012, Vol. 5 Issue 3, p180
Academic Journal
The present study involves in the preparation and evaluation of floating tablets of Voriconazole by wet granulation method by using the hydrophilic polymer such as hydroxy propyl methyl cellulose (HPMC K4M) and Carbopol 934 P. Sodium bicarbonate and citric acid were incorporated as gas generating agent. The study aims to achieve extended retention in the stomach which may result in prolonged absorption in proximal part of the small intestine. The prepared tablets were evaluated in terms of thickness, average weight, hardness, friability, drug content uniformity, swelling index, in- vitro buoyancy study and in-vitro dissolution study. The formulated tablet Hardness was found to being the range of 5.5 ?0.42 to 7.0?0.35 kg/cm2, the % friability was in the range of 0.72+ 0.26 to 0.96+ 0.14. In-vitro release studies were carried out using USP XXII dissolution test apparatus. The tablet containing Voriconazole was released from batch F1-F5 found to be 75.12 to 97.2 %. The release of drug from tablets sufficiently sustained for 12 hours by in vitro release study. The lower polymer to drug ratio there was a significant increase in drug release, F2 found to be the best formulation.


Related Articles

  • Formulation and in vitro evaluation of floating tablets of hydroxypropyl methylcellulose and polyethylene oxide using ranitidine hydrochloride as a model drug. Gharti, K. P.; Thapa, P.; Budhathoki, U.; Bhargava, A. // Journal of Young Pharmacists;Oct-Dec2012, Vol. 4 Issue 4, p201 

    The present study was carried out with an objective of preparation and in vitro evaluation of floating tablets of hydroxypropyl methyl cellulose (HPMC) and polyethylene oxide (PEO) using ranitidine hydrochloride as a model drug. The floating tablets were based on effervescent approach using...

  • FORMULATION DEVELOPMENT AND EVALUATION OF IN SITU GEL FOR VAGINAL DRUG DELIVERY OF ANTI FUNGAL DRUG. Akhani, Jolly R.; Modi, Chetna D. // Pharma Science Monitor;Apr-Jun2014, Vol. 5 Issue 2, Supp 1, p343 

    The aim of the present study was to formulate and evaluate nystatin containing thermosensitive mucoadhesive gel for vaginal drug delivery to achieve prolonging the residence time, sustained drug release, enhancing efficacy, decreasing recurrence, and increasing patient compliance in the...

  • FORMULATION AND EVALUATION OF EFFERVESCENT FLOATING TABLETS OF ANTI HYPERTENSIVE DRUG. Thesiya, Neeta B.; Shah, Arvind; Bhutt, Chandresh A. // Pharma Science Monitor;Apr-Jun2014, Vol. 5 Issue 2, Supp 1, p313 

    The aim of present investigation is Formulation and Evaluation of Effervescent floating tablets of antihypertensive drug by using HPC-H, sodium bicarbonate and citric acid. Gastric retention systems are such systems, which increase the gastric retention time of the dosage forms at the stomach...

  • FORMULATION, EVALUATION AND OPTIMIZATION OF PRESS COATED PULSATILE TABLET OF ZALTOPROFEN FOR THE TREATMENT OF RHEUMATOID ARTHRITIS. Kukadiya, Chetan G.; Desai, Kesha; Swamy, S. M. Vijayendra // Pharma Science Monitor;Apr-Jun2014, Vol. 5 Issue 2, Supp 1, p153 

    The aim of the present study was to formulate, evaluate and optimize press coated pulsatile tablet of Zaltoprofen for the treatment of rheumatoid arthritis. The drug delivery system is based on the concept of chronotherapeutics. Dosage form provide delayed release up to 5 hour and after...

  • Formulation and Evaluation of Aceclofenac Sustained Release Tablets. Kumar, Srinivas Ashok; Jagdale, Swati C. // International Journal of Pharmaceutical Sciences Review & Resear;Sep/Oct2014, Vol. 28 Issue 2, p59 

    Increase in complication and expenses involved in marketing of new drug entities has focused greater attention in development of sustained release drug delivery system of existing drugs. NSAID are having short biological half life of 4-4.3 hrs and fluctuation in drug plasma concentration. NSAID...

  • Quality evaluation and in vitro interaction studies between levofloxacin 250mg and diclofenac sodium 50mg tablets. Fayyaz, Muhammad; Yousuf, Rabia Ismail; Shoaib, Muhammad Harris; Ali, Tariq; Nasiri, Iqbal; Ashraf, Nida // Pakistan Journal of Pharmaceutical Sciences;Jan2015, Vol. 28 Issue 1, p119 

    Fluoroquinolones are broad-spectrum antibiotics, work against Gram-positive and Gram-negative bacteria and are a clinically proven option for many resistant infections. Among fluoroquinolones Levofloxacin works best against acute sinusitis, inflammation of the lower airways, acute exacerbation...

  • Synthesis and Biological Evaluation of Some Novel 3,5-Disubstituted-1,2,4-triazole Incorporated 2-Mercaptobenzothiazoles. Azam, Mohammed Afzal; Suresh, Bhojraj; Srinivas, Naga; Sachdev, Sumit; Rajeshkumar, Raman // Acta Chimica Slovenica;2012, Vol. 59 Issue 4, p739 

    Several 2-mercaptobenzothiazole derivatives 5a-i containing 1,2,4-triazole moiety incorporating two additional substituents were synthesized. All the newly synthesized compounds were tested for in vitro activity against certain strains of bacteria such as Enterococcus faecalis, Bacillus...

  • STABILITY STUDIES OF FAST DISPERSIBLE KETOPROFEN 100 mg TABLETS. Zafar, Farya; Shoaib, Muhammad Harris; Yousuf, Rabia Ismail // International Journal of Pharmaceutical Sciences Review & Resear;Mar/Apr2012, Vol. 13 Issue 2, p58 

    In the present study long term testing (12 month) and accelerated testing (6 month) were carried out on fast dispersible Ketoprofen 100 mg tablets in order to assess the physical and chemical stability of Ketoprofen tablets. All the formulations were tested for disintegration test, % drug...

  • Selection of excipients for dispersible tablets of itraconazole through the application of thermal techniques and Raman spectroscopy. Wang, Yan; Luo, Yang-Hui; Zhao, Jing; Sun, Bai-Wang // Journal of Thermal Analysis & Calorimetry;Mar2014, Vol. 115 Issue 3, p2391 

    For the development of dispersible tablets of itraconazole (ITR), techniques of thermal, Raman spectroscopy, and isothermal stress testing (IST) were used to assess the compatibility of ITR with selected excipients. Initially, differential scanning calorimeter (DSC) was used to evaluate the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics