The sciences converge to fight cancer

Agus, David B.; Michor, Franziska
November 2012
Nature Physics;Nov2012, Vol. 8 Issue 11, p773
Academic Journal
The author focuses on the new discoveries in cancer research and also discusses the role of molecular biology in developing treatment strategies for cancer. It informs that molecular signals have been identified which are involved in intracellular pathway and extracellular communication and also discusses several techniques including genome sequencing, proteomic and metabolomic analysis.


Related Articles

  • Phosphoproteomics and Lung Cancer Research. López, Elena; S. Cho, William C. // International Journal of Molecular Sciences;Oct2012, Vol. 13 Issue 10, p12287 

    Massive evidence suggests that genetic abnormalities contribute to the development of lung cancer. These molecular abnormalities may serve as diagnostic, prognostic and predictive biomarkers for this deadly disease. It is imperative to search these biomarkers in different tumorigenesis pathways...

  • REDOX CELL SIGNALING GENOMICS AND PROTEOMICS TARGET PLACE MODULATORS IN CANCEROGENEIS: NEW DIAGNOSTIC AND THERAPEUTIC POSSIBILITIES. Pavlović, Dušica; Kocić, Gordana; Stoimenov, Tatjana Jevtović // Jugoslovenska Medicinska Biohemija / Yugoslav Medical Biochemist;Dec2006, Vol. 25 Issue 4, p309 

    Within the complex process of signal transduction through the cell under the influence of external factors, signal transmission is initiated through a specific communication, protein-protein interaction (phosphorylation, dephosphorylation, association, dissociation, oxidation, glycation,...

  • Proteomic and Computational Methods in Systems Modeling of Cellular Signaling. Kleppe, R.; Kjarland, E.; Selheim, F. // Current Pharmaceutical Biotechnology;Jun2006, Vol. 7 Issue 3, p135 

    Cellular signaling lies at the core of cellular behavior, and is central for the understanding of many pathologicconditions. To comprehend how signal transduction is orchestrated at the molecular level remains the ultimate challengefor cell biology. In the last years there has been a revolution...

  • Kinomics. Gomase, Virendra S.; Tagore, Somnath // Current Drug Metabolism;Mar2008, Vol. 9 Issue 3, p255 

    Kinomics is derived from the word kinome that is the kinase part of the proteome. Kinomics is a merger between genomics and proteomics. Defining the kinase complement of the human genome, the kinome, has provided an excellent starting point for understanding the scale of the problem. This...

  • A Glimpse to Background and Characteristics of Major Molecular Biological Networks. Altaf-Ul-Amin, Md.; Katsuragi, Tetsuo; Sato, Tetsuo; Kanaya, Shigehiko // BioMed Research International;9/30/2015, Vol. 2015, p1 

    Recently, biology has become a data intensive science because of huge data sets produced by high throughput molecular biological experiments in diverse areas including the fields of genomics, transcriptomics, proteomics, and metabolomics. These huge datasets have paved the way for system-level...

  • The role of PI-3 kinase in cancer biology and approaches to the therapeutics of cancer. Babu Vimalanathan, A.; Kanikkai Raja, A.; Tyagi, Manoj G. // Biology & Medicine;Oct-Dec2009, Vol. 1 Issue 4, p1 

    Many types of immune cellular stimulation or toxic insults activate the generalized systemic PI3K/AKT pathway and it regulates the basic cellular functions such as transcription, proliferation, growth and survival. The modified and disturbed activation of these pathway result in development of...

  • Signal Transduction of Radiation and/or Hyperthermic Cancer Therapies. Ohnishi, Takeo; Takahashi, Akihisa // Current Signal Transduction Therapy;Sep2010, Vol. 5 Issue 3, p231 

    In order to achieve a high efficacy in cancer therapies which use radiation and/or hyperthermia, it is necessary to study and understand two important signal transduction pathways which can depress cell survival signals and simultaneously enhance cell death signals. Recent progress in molecular...

  • TP53 and Let-7a micro-RNA Regulate K-Ras Activity in HCT116 Colorectal Cancer Cells. Luu, Carrie; Heinrich, Eileen L.; Duldulao, Marjun; Arrington, Amanda K.; Fakih, Marwan; Garcia-Aguilar, Julio; Kim, Joseph // PLoS ONE;Aug2013, Vol. 8 Issue 8, p1 

    Recent reports have indicated that KRAS and TP53 mutations predict response to therapy in colorectal cancer. However, little is known about the relationship between these two common genetic alterations. Micro-RNAs (miRNAs), a class of noncoding RNA implicated in cellular processes, have been...

  • Genome-wide analysis of alternative splicing in Volvox carteri. Kianianmomeni, Arash; Cheng Soon Ong; Rätsch, Gunnar; Hallmann, Armin // BMC Genomics;2014, Vol. 15 Issue 1, p1690 

    Background: Alternative splicing is an essential mechanism for increasing transcriptome and proteome diversity in eukaryotes. Particularly in multicellular eukaryotes, this mechanism is involved in the regulation of developmental and physiological processes like growth, differentiation and...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics