TITLE

EFFECT OF IONTOPHORESIS AND PENETRATION ENHANCERS ON THE IN VITRO DIFFUSION OF A PIROXICAM GEL

AUTHOR(S)
WATHONI, NASRUL; PAMUDJI, JESSIE SOFIA; DARIJANTO, SASANTITARINI
PUB. DATE
October 2012
SOURCE
International Journal of Pharmacy & Pharmaceutical Sciences;Oct-Dec2012, Vol. 4 Issue 4, p215
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The stratum corneum behaves as a barrier for most of drugs percutaneous absorption into the body. The ability of drug to penetrate the stratum corneum can be improved by using physical and chemical methods. The purpose of this study is to determine the effect of penetrance enhancers addition and application of iontophoresis method on diffusion of piroxicam gel preparation in vitro. The study was performed with flow through method for 6 hours using porcine ears skin as a diffusion membran; ethanol, ethyl acetate, tween 80 and dimethyl sulfoxide (DMSO) as penetrance enhancers; and 0.5 mA/cm² constant current for iontophoresis method. The result showed that the piroxicam diffusions from the formula with penetrance enhancer were : F1 (ethanol 5%) > F3 (ethyl acetate 5%) > F4 (Tween 80 5%) > F2 (DMSO 5%) > FS (without penetrance enhancer) respectively. The amount of drug diffused by iontophoresis method was twice higher than in original formula (FS) without iontophoresis. The combination effect of penetrance enhancer and iontophoresis showed a better synergic effect in the formula F1 and F3, while in F2 and F4 was unclear.
ACCESSION #
82826595

 

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