October 2012
International Journal of Pharmacy & Pharmaceutical Sciences;Oct-Dec2012, Vol. 4 Issue 4, p215
Academic Journal
The stratum corneum behaves as a barrier for most of drugs percutaneous absorption into the body. The ability of drug to penetrate the stratum corneum can be improved by using physical and chemical methods. The purpose of this study is to determine the effect of penetrance enhancers addition and application of iontophoresis method on diffusion of piroxicam gel preparation in vitro. The study was performed with flow through method for 6 hours using porcine ears skin as a diffusion membran; ethanol, ethyl acetate, tween 80 and dimethyl sulfoxide (DMSO) as penetrance enhancers; and 0.5 mA/cm² constant current for iontophoresis method. The result showed that the piroxicam diffusions from the formula with penetrance enhancer were : F1 (ethanol 5%) > F3 (ethyl acetate 5%) > F4 (Tween 80 5%) > F2 (DMSO 5%) > FS (without penetrance enhancer) respectively. The amount of drug diffused by iontophoresis method was twice higher than in original formula (FS) without iontophoresis. The combination effect of penetrance enhancer and iontophoresis showed a better synergic effect in the formula F1 and F3, while in F2 and F4 was unclear.


Related Articles

  • Validated HPTLC method for mangiferin in Salacia chinensis. Smitha, G. Nadagouda; Asif, A. Karigar; Joshi, V. G.; Sikarwar^Mukesh, S. // Journal of Pharmacy Research;May2010, Vol. 3 Issue 5, p1107 

    A high performance thin layer chromatographic (HPTLC) method was developed and validated as per ICH (International conferences on harmonization) guidelines for simultaneous quantification of mangiferin in Salacia chinensis roots. For achieving good separation mobile phase of ethyl acetate...

  • Interference from ordinarily used solvents in the outcomes of Artemia salina lethality test. Geethaa, Sahgal; Thavamany, Priscilla Jayanthi; Siah Poh Chiew; Ong Ming Thong // Journal of Advanced Pharmaceutical Technology & Research;Oct-Dec2013, Vol. 4 Issue 4, p179 

    Methanol, ethanol, Tween 20 and dimethyl sulfoxide (DMSO) are widely used as dissolving agents in Artemia salina lethality test (aka brine shrimp lethality test [BSLT]) to screen the pharmaceutical properties of natural products. Nevertheless, there is lack of toxicity level of these solvents...

  • EFFECT OF DIMETHYL SULFOXIDE AND FICOLL ON RAT SKIN. Fine, Albert S.; Stahl, S.; Kopac, M. J. // Journal of Investigative Dermatology;May72, Vol. 58 Issue 5, p269 

    The cytochrome oxidase of skin has been characterized biochemically in the presence of DMSO and Ficoll. The pH optimum for the oxidation of ferrocytochrome c was found to be very sensitive to changes in ionic strength of the phosphate buffer. Maxima were observed at pH 7.0 in constant molarity...

  • Efeito dos extratos aquoso e etanólico da casca do angico preto (Anadenanthera macrocarpa) sobre teleóginas de Rhipicephalus (Boophilus) microplus. Lopes da Silva Filho, Manoel; Moreno Fernandes, Rozeverter; Lima das Chagas Moreno Fernandes, Maria Zenaide; Sousa Batista, Maria Carmo; Lopes Silva, José Algaci; Soares Lopes, Glauciany // Comunicata Scientiae;out-dez2013, Vol. 4 Issue 4, p324 

    This research was carried out to determine the effect of aqueous (AE) and ethanolic skin extracts (EE) of Anadenanthera macrocarpa on the oviposition and the egg eclodibility of teleogines of Rhipicephalus (Boophilus) microplus. The concentrations used were AE and EE 8.26 mg.mL-1 and 12.5 mg...

  • Interaction of organic solvents with the green alga Chlorella pyrenoidosa. Stratton, Glenn; Smith, Tara // Bulletin of Environmental Contamination & Toxicology;May1988, Vol. 40 Issue 5, p736 

    The article presents a comparative research study on the inhibitory effects of solvents used in pesticide bioassays on the growth of common green alga Chlorella pyrenoidosa. It examines the occurrence of the interactions of solvent-pesticides including dimethyl sulfoxide (DMSO), ethanol, and...

  • Assessment of Flavonoid Release with Different Permeation Enhancers. Vaisakh, M. N.; Pandey, A. // International Journal of Pharmaceutical Sciences & Drug Research;Apr-Jun2012, Vol. 4 Issue 2, p154 

    The aim of the study was to evaluate the effect of different permeation enhancers in the transdermal permeation of flavonoids. A weed plant named Chromolaena odorata have been employed as the flavonoid source. Six different cream formulations have been prepared with the Chromolaena extract using...

  • Stability of fluctuating and transient aggregates of amphiphilic solutes in aqueous binary mixtures: Studies of dimethylsulfoxide, ethanol, and tert-butyl alcohol. Banerjee, Saikat; Bagchi, Biman // Journal of Chemical Physics;Oct2013, Vol. 139 Issue 16, p164301 

    In aqueous binary mixtures, amphiphilic solutes such as dimethylsulfoxide (DMSO), ethanol, tert-butyl alcohol (TBA), etc., are known to form aggregates (or large clusters) at small to intermediate solute concentrations. These aggregates are transient in nature. Although the system remains...

  • Chitosan acetic-acid forming solutions and control of the properties determining their capability for electroforming. Sonina, A.; Vikhoreva, G.; Morgunov, G.; Gal'braikh, L. // Fibre Chemistry;Jul2012, Vol. 44 Issue 2, p79 

    The effect of co-solvent additives of dimethylsulfoxide and ethanol on the electrical conductivity, surface tension, and structural and rheological properties of forming solutions of chitosan and their behavior under electroforming conditions were studied. It was shown that EtOH was the most...

  • Isolation and Characterization of Phenolic Antioxidants from Plantago Herb. Amakura, Yoshiaki; Yoshimura, Ayako; Yoshimura, Morio; Yoshida, Takashi // Molecules;May2012, Vol. 17 Issue 5, p5459 

    Seven phenolic compounds, including a new phenylethanoid glycoside, were isolated from the ethyl acetate fraction of an aqueous ethanol extract of Plantago Herb (whole part of Plantago asiatica L.), which showed significant antioxidative activity. The new compound was characterized as...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics