IgA is important for clearance and critical for protection from rotavirus infection

Blutt, S E; Miller, A D; Salmon, S L; Metzger, D W; Conner, M E
November 2012
Mucosal Immunology (1933-0219);Nov2012, Vol. 5 Issue 6, p712
Academic Journal
Based on a lack of severe phenotype in human immunoglobulin A (IgA) deficiency syndromes, the role of IgA in controlling respiratory and gastrointestinal (GI) infections has not been clearly defined. C57BL/6 and BALB/c mice lacking IgA (IgA−/−) were developed and used to address this question. When exposed to a common GI virus, rotavirus, IgA−/− mice exhibited a substantial and significant delay in clearance of the initial infection compared with wild-type mice. IgA−/− mice excreted rotavirus in stool up to 3 weeks after the initial exposure compared with 10 days observed in wild-type mice. Importantly, IgA−/− mice failed to develop protective immunity against multiple repeat exposures to the virus. All IgA−/− mice excreted virus in the stool upon re-exposure to rotavirus, whereas wild-type mice were completely protected against re-infection. These findings clearly indicate a critical role for IgA in the establishment of immunity against a GI viral pathogen.


Related Articles

  • Helicobacter pylori Prevalence among Indigenous Peoples of South America. Robinson, Lisa-Gaye E.; Black, Francis L.; Lee, Francis K.; Sousa, Alexandra O.; Owens, Marilyn; Danielsson, Dan; Nahmias, André J.; Gold, Benjamin D. // Journal of Infectious Diseases;10/15/2002, Vol. 186 Issue 8, p1131 

    The seroprevalence of Helicobacter pylori among secluded Indian populations of South America was determined to gain insight into the evolutionary history and possible transmission patterns of the organism. Serum samples obtained from 1024 donors in 22 different villages were tested by...

  • Prediction and Identification of Potential Immunodominant Epitopes in Glycoproteins B, C, E, G, and I of Herpes Simplex Virus Type 2. Mingjie Pan; Xingsheng Wang; Jianmin Liao; Dengke Yin; Suqin Li; Ying Pan; Yao Wang; Guangyan Xie; Shumin Zhang; Yuexi Li // Clinical & Developmental Immunology;2012, p1 

    Twenty B candidate epitopes of glycoproteins B (gB2), C (gC2), E (gE2), G (gG2), and I (gI2) of herpes simplex virus type 2 (HSV-2) were predicted using DNAstar, Biosun, and Antheprot methods combined with the polynomial method. Subsequently, the biological functions of the peptides were tested...

  • IgG in cervicovaginal mucus traps HSV and prevents vaginal Herpes infections. Wang, Y-Y; Kannan, A; Nunn, K L; Murphy, M A; Subramani, D B; Moench, T; Cone, R; Lai, S K // Mucosal Immunology (1933-0219);Sep2014, Vol. 7 Issue 5, p1036 

    IgG is the predominant immunoglobulin in cervicovaginal mucus (CVM), yet how immunoglobulin G (IgG) in mucus can protect against infections is not fully understood. IgG diffuses rapidly through cervical mucus, slowed only slightly by transient adhesive interactions with mucins. We hypothesize...

  • Antibody to herpes simplex virus type 2 as serological marker of sexual lifestyle in populations. Cowan, Frances M.; Johnson, Anne M.; Ashley, Rhoda; Corey, Lawrence; Mindel, Adrian // BMJ: British Medical Journal (International Edition);11/19/94, Vol. 309 Issue 6965, p1325 

    Assesses the suitability of herpes simplex virus types 2 as a serological marker of sexual behavior in London population in England. Epidemiology of antibody to herpes simplex virus type 2; Association of antibody with sexual orientation and years of sexual activity of population; Prevalence of...

  • Characterisation of IE and UL5 gene products of equine herpesvirus 1 using DNA inoculation of mice. Koen, M. T.; Walker, C.; Wellington, J. E.; Love, D. N.; Whalley, J. M. // Archives of Virology;Dec2000, Vol. 145 Issue 12, p2677 

    Summary. The equine herpesvirus 1 (EHV-1) strain HVS25A regulatory genes IE and UL5, encoding homologues of herpes simplex virus 1 (HSV-1) ICP4 and ICP27 respectively, were cloned into a eukaryotic expression vector and the DNA injected intramuscularly into mice. Antibodies produced in this way...

  • La gD2 coadministrada con el AFCo1 por vía intranasal induce inmunidad protectora contra virus de herpes simple tipo 2 en ratones. Cabrera, Osmir; Cuello, Maribel; Thörn, Karolina; Peerson, Josefine; Lindqvist, Madelene; Lastre, Miriam; González, Elizabeth; Zayas, Caridad; Balboa, Julio; Romeo, Belkis; Sarandi, Ali; Pérez, Oliver // Revista VacciMonitor (Vacunología y Temas Afines);sep-dic2012, Vol. 21 Issue 3, p19 

    Sexually transmitted infections by Herpes Simplex Virus type 2 (HSV-2) are the leading cause of genital ulcers and a major public health problem worldwide. This requires the use of mucosal vaccines, because parenteral vaccines have not been successful. Presently, there are not mucosal adjuvants,...

  • Pan-HSV-2 IgG Antibody in Vaccinated Mice and Guinea Pigs Correlates with Protection against Herpes Simplex Virus 2. Halford, William P.; Geltz, Joshua; Gershburg, Edward // PLoS ONE;Jun2013, Vol. 8 Issue 6, p1 

    We lack a correlate of immunity to herpes simplex virus 2 (HSV-2) that may be used to differentiate whether a HSV-2 vaccine elicits robust or anemic protection against genital herpes. This gap in knowledge is often attributed to a failure to measure the correct component of the adaptive immune...

  • Prime immunization with rotavirus VLP 2/6 followed by boosting with an adenovirus expressing VP6 induces protective immunization against rotavirus in mice. Hongli Zhou; Li Guo; Min Wang; Jianguo Qu; Zhendong Zhao; Jianwei Wang; Tao Hung // Virology Journal;2011, Vol. 8 Issue 1, p1 

    Background: Rotavirus (RV) is the main cause of severe gastroenteritis in children. An effective vaccination regime against RV can substantially reduce morbidity and mortality. Previous studies have demonstrated the efficacy of virus-like particles formed by RV VP2 and VP6 (VLP2/6), as well as...

  • Towards an Understanding of the Herpes Simplex Virus Type 1 Latency-Reactivation Cycle. Guey-Chuen Perng; Jones, Clinton // Interdisciplinary Perspectives on Infectious Diseases;2010, p1 

    Infection by herpes simplex virus type 1 (HSV-1) can cause clinical symptoms in the peripheral and central nervous system. Recurrent ocular shedding can lead to corneal scarring and vision loss making HSV-1 a leading cause of corneal blindness due to an infectious agent. The primary site of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics