TITLE

Expression and Significance of Raf Kinase Inhibitory Protein in Lung Cancer

AUTHOR(S)
Dayun Yang; Zhan Qi
PUB. DATE
October 2012
SOURCE
Chinese Journal of Lung Cancer;Oct2012, Vol. 15 Issue 10, p597
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background and objective Raf kinase inhibitory protein (RKIP) belongs to the phosphatidylethanolamine binding protein family. RKIP is an endogenous inhibitor of the ERK/MAPK, NF-κB, and G protein-coupled receptor signaling pathways. This study aims to investigate the expression of RKIP in non-small cell lung cancer (NSCLC) and to determine the association of RKIP expression with the clinicopathologic features of NSCLC. Methods Reverse transcriptionpolymerase chain reaction, Western blot, and immunohistochemistry were used to detect RKIP expression in 83 specimens with NSCLC and normal lung tissues and to analyze the association of RKIP expression with the clinicopathologic features of NSCLC. All cases were confirmed by pathological diagnosis, and primary tumors were not found at other sites. No medical records of preoperative radiotherapy, chemotherapy, and immunotherapy were found in the groups. Results RKIP expression was down-regulated significantly in NSCLC compared with adjacent cancer tissues (P<0.05). It was associated with differentiation, pathological tumor-node-metastasis stage, survival time, and lympho invasion (P<0.05) but not with gender, smoking status, age, tumor size, and histologic type (P>0.05). Conclusion The deficiency of RKIP expression is positively correlated with carcinogenesis and invasion metastasis of NSCLC. RKIP is a potential marker and target for clinic therapy.
ACCESSION #
82716974

 

Related Articles

  • Correlation Between Expression of Extracellular Matrix Metalloproteinase Inducer and Matrix Metalloproteinase-2 and Cervical Lymph Node Metastasis of Nasopharyngeal Carcinoma. Tian Huang; Mao-Huai Chen; Ming-Yao Wu; Xian-Ying Wu // Annals of Otology, Rhinology & Laryngology;Mar2013, Vol. 122 Issue 3, p210 

    Objectives: We evaluated the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix me- talloproteinase-2 (MMP-2) in nasopharyngeal carcinoma (NPC) and studied their relationship with cervical lymph node metastasis. ¦ Methods: Immunohistochemical staining was used...

  • Expression and Related Factors of Galectin-3 in Non-small Cell Lung Cancer. Meiyan LIU; Bing DU; Chunhong LI; Yanbin ZHAO; Qingwei MENG; Li CAI // Chinese Journal of Lung Cancer;Aug2013, Vol. 16 Issue 8, p417 

    Background and objective: Galectin-3 is involved in many physical and pathologic process, and is closely correlated with tumorigenesis, development and metastasis. The aim of this study is to investigate the gene expression and significance of Galectin-3 in normal lung tissue and non-small cell...

  • Abnormal expression of Tie1 on the valves of great saphenous varicose vein. Xin Wang; Rong Zhao; Changjian Liu; Tong Qiao // Phlebology;Mar2013, Vol. 28 Issue 2, p93 

    Objective: To investigate the abnormal expressions of Tie1 on the valves of great saphenous varicose vein, and to discuss the relationship between the phenomenon and pathogenesis of varicose vein of lower extremity. Methods: Varicose veins group 18 samples, normal control group 14 samples....

  • Expression and Significance of Snail and Claudin-3 in Non-small Cell Lung Cancer. Juan Li; Yuan Tu; Lili Jiang; Huan Xu; Shangfu Zhang // Chinese Journal of Lung Cancer;Oct2012, Vol. 15 Issue 10, p583 

    Background and objective Epithelial-mesenchymal transition (EMT) is considered to be one of the major molecular mechanisms inducing tumor invasion and metastasis. The loss of epithelial cell polarity is a hallmark of the EMT process. Epithelial markers such as Claudin are lost in EMT. Snail is a...

  • Expression and clinical significance of Nectin-4 in hepatocellular carcinoma. Jie Ma; ZhiYong Sheng; Yang Lv; WenBin Liu; QiYang Yao; TingTing Pan; ZhiJun Xu; ChuanHai Zhang; GeLiang Xu // OncoTargets & Therapy;Jan2016, Vol. 9, p183 

    Objective: Nectin-4 is a member of the Nectin family of four Ca+-independent immunoglobulin-like cell adhesion molecules and implicated in cell adhesion, movement, proliferation, differentiation, polarization, and survival. The aberrant expression of Nectin-4 has been found in a variety of...

  • Transketolase-Like 1 Expression Is Modulated during Colorectal Cancer Progression and Metastasis Formation. Diaz-Moralli, Santiago; Tarrado-Castellarnau, Miriam; Alenda, Cristina; Castells, Antoni; Cascante, Marta // PLoS ONE;2011, Vol. 6 Issue 9, p1 

    Background: Transketolase-like 1 (TKTL1) induces glucose degradation through anaerobic pathways, even in presence of oxygen, favoring the malignant aerobic glycolytic phenotype characteristic of tumor cells. As TKTL1 appears to be a valid biomarker for cancer prognosis, the aim of the current...

  • The Serine Protease Plasmin Triggers Expression of the CC-Chemokine Ligand 20 in Dendritic Cells via Akt/NF-κB-Dependent Pathways. Xuehua Li; Syrovets, Tatiana; Simmet, Thomas // Journal of Biomedicine & Biotechnology;2012, Vol. 2012, p1 

    The number of dendritic cells is increased in advanced atherosclerotic lesions. In addition, plasmin, which might stimulate dendritic cells, is generated in atherosclerotic lesions. Here, we investigated cytokine and chemokine induction by plasmin in human dendritic cells. In human...

  • Expression of THOP1 and Its Relationship to Prognosis in Non-Small Cell Lung Cancer. Qi, Lei; Li, Shu-hai; Si, Li-bo; Lu, Ming; Tian, Hui // PLoS ONE;Sep2014, Vol. 9 Issue 9, p1 

    Background: The study was designed to detect the expression level of thimet oligopeptidase (THOP1) protein in non-small cell lung cancer (NSCLC) and investigate its correlation with clinicopathologic features and prognosis. Methods: Immunohistochemical staining was used to determine the...

  • Clinicopathological Correlation and Prognostic Significance of Protein Kinase Cα Overexpression in Human Gastric Carcinoma. Lin, Shee-Chan; Chen, Wei-Yu; Lin, Kai-Yuan; Chen, Sheng-Hsuan; Chang, Chun-Chao; Lin, Sey-En; Fang, Chia-Lang // PLoS ONE;Feb2013, Vol. 8 Issue 2, p1 

    Objectives: This study investigated the PKCα protein expression in gastric carcinoma, and correlated it with clinicopathological parameters. The prognostic significance of PKCα protein expression in gastric carcinoma was analyzed. Methods: Quantitative real-time PCR test was applied...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics