TITLE

Dietary resveratrol increases the expression of hepatic 7α-hydroxylase and ameliorates hypercholesterolemia in high-fat fed C57BL/6J mice

AUTHOR(S)
Qiong Chen; Ermao Wang; Liping Ma; Pei Zhai
PUB. DATE
January 2012
SOURCE
Lipids in Health & Disease;2012, Vol. 11 Issue 1, p56
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Resveratrol (RSV), a naturally occurring polyphenolic stilbenoid, is known to possess potent anti-atherogenic properties; however, the effect of RSV on hypercholesterolemia is not fully understood. We hypothesized that RSV decreases blood cholesterol levels through the activation of cholesterol 7α-hydroxylase (CYP7A1)-mediated bile acid synthetic pathway pathways in vitro and in vivo. Methods: In this study, we evaluated body weight, serum lipid concentrations, hepatic lipid content and the size of the bile acid pool in high-fat diet (HFD)-fed C57BL/6 J mice that were treated with RSV. In addition, we characterized the underlying mechanism of the effects of RSV in HepG2 hepatocytes by Western blot analysis. Results: RSV (200 mg/kg per day) reduced body weight and liver weight gains, improved serum lipid parameters, reduced hepatic cholesterol accumulation and increased the bile acid pool size in mice fed an HFD for 8 wks. RSV significantly increased liver expression of CYP7A1 mRNA and protein and CYP7A1 enzyme activity. Furthermore, RSV treatment upregulated CYP7A1 expression and induced liver X receptor alpha (LXRα) activation in a time- and dose-dependent manner in HepG2 cells. In addition, the specific liver X receptor alpha (LXRα) inhibitor geranylgeranyl pyrophosphate (GGPP) inhibited the RSV-induced expression of CYP7A1 in HepG2 hepatocytes. Conclusion: The beneficial effects of RSV on HFD-induced hypercholesterolemia are mediated through LXRα signaling pathways, suggesting a potential target for the prevention of dyslipidemia.
ACCESSION #
82529879

 

Related Articles

  • Plant sterol ester-enriched milk and yoghurt effectively reduce serum cholesterol in modestly hypercholesterolemic subjects. Noakes, Manny; Clifton, Peter M.; Doornbos, Anne M. E.; Trautwein, Elke A. // European Journal of Nutrition;Jun2005, Vol. 44 Issue 4, p214 

    Background The cholesterol-lowering efficacy of plant sterol esters (PSteE) or stanol esters (PStaE) in regular- and low-fat spreads has been consistently demonstrated, while their effectiveness in a low-fat, aqueous food carrier such as milk and yoghurt is less well established. Aim of the...

  • Effects of Surface-Deacetylated Chitin Nanofibers in an Experimental Model of Hypercholesterolemia. Kazuo Azuma; Tomone Nagae; Takeshi Nagai; Hironori Izawa; Minoru Morimoto; Yusuke Murahata; Tomohiro Osaki; Takeshi Tsuka; Tomohiro Imagawa; Norihiko Ito; Yoshiharu Okamoto; Hiroyuki Saimoto; Shinsuke Ifuku // International Journal of Molecular Sciences;Aug2015, Vol. 16 Issue 8, p17445 

    This study evaluated the effects of oral administration of surface-deacetylated chitin nanofibers (SDACNFs) on hypercholesterolemia using an experimental model. All rats were fed a high cholesterol diet with 1% w/w cholesterol and 0.5% w/w cholic acid for 28 days. Rats were divided equally into...

  • Ezetimibe for Hypercholesterolemia. Morris, Spencer; Tiller, Rob // American Family Physician;10/15/2003, Vol. 68 Issue 8, p1595 

    Presents an update related to ezetimibe, a drug therapy for the treatment of hypercholesterolemia. Mechanism of action; Safety considerations; Tolerability; Effectiveness.

  • Hearing Loss Due to Familial Hypercholesterolemia and Statin Treatment. Oylumlu, Muhammed; Lolan, Faris Mahmode; Ercan, Suleyman; Altunbas, Gokhan; Karatas, Zeynel; Davutoglu, Vedat // European Journal of Cardiovascular Medicine;2013, Vol. 2 Issue 4, p224 

    It has been suggested that high cholesterol levels might have adverse effects on hearing and interestingly statins may have beneficial effects on hearing loss. Herein, we share a dramatic improvement in acute hearing loss by statin administration in a young patient with familial...

  • The dangers of high cholesterol levels are well known--but low levels may also have hidden risks. Greenhalgh, Trisha // Accountancy;Oct95, Vol. 116 Issue 1226, p62 

    Focuses on health risks posed by both high- and low-levels of cholesterol in the body. Diseases resulting from high levels of lipoproteins; Association of cholesterol-lowering treatments with accidental and premeditated violent death; Debate about cholesterol in the medical press.

  • EXPERIMENTAL AORTIC ATHEROSCLEROSIS IN RABBITS FOLLOWING THE INGESTION OF DIHYDROCHOLESTEROL. Sieracki, Joseph C.; Beher, W. T.; Baker, G. D. // Angiology;Aug1960, Vol. 11 Issue 4, p343 

    Ingested dihydrocholesterol, a constant companion of cholesterol, is atherogenic in rabbits. The atherosrlerosis is different from that seen in cholesterol fed rabbits. The histologic sequence of events in these lesions over a 51-week period is described in some detail. The lesions occurred in...

  • Effects of Low-Dose Atorvastatin and Rosuvastatin on Plasma Lipid Profiles: A Long-Term, Randomized, Open-Label Study in Patients with Primary Hypercholesterolemia. Mazza, Fabio; Stefanutti, Claudia; Di Giacomo, Serafina; Vivenzio, Antonio; Fraone, Nadia; Mazzarella, Bruno; Bucci, Antonello // American Journal of Cardiovascular Drugs;2008, Vol. 8 Issue 4, p265 

    BACKGROUND AND OBJECTIVE: Despite the favorable effects of reduction of low-density lipoprotein-cholesterol (LDL-C) levels in decreasing the risk of coronary heart disease, many patients treated with lipid-lowering HMG-CoA reductase inhibitors (statins) do not achieve goal LDL-C levels. This...

  • SERUM CHOLESTEROL AS A PREDICTOR OF CAPILLAROPATHY. Barrett, R. A.; Cheraskin, E.; Ringsdorf Jr., W. M. // Angiology;Jul/Aug1970, Vol. 21 Issue 7, p462 

    The article presents a report on serum cholesterol as a predictor of capillaropathy. The association of serum cholesterol with large vessel pathosis is well known. An elevated level of circulating cholesterol has long been recognized as a diagnostic indicator of the arterioselerotic process....

  • Brain region-dependent increases in β-amyloid and apolipoprotein E levels in hypercholesterolemic rabbits. Wu, C.-W.; Liao, P.-C.; Lin, C.; Kuo, C.-J.; Chen, S.-T.; Chen, H.-I.; Kuo, Y.-M. // Journal of Neural Transmission;Jun2003, Vol. 110 Issue 6, p641 

    Summary. Recent studies indicate a possible link between serum cholesterol level, β-amyloid (Aβ) peptide concentrations, and the incidence of Alzheimer's disease (AD). In the present report, the effects of dietary cholesterol on Aβ and apolipoprotein E (APOE) levels in several brain...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics