pH-responsive high-density lipoprotein-like nanoparticles to release paclitaxel at acidic pH in cancer chemotherapy

Jae-Yoon Shin; Yoosoo Yang; Paul Heo; Ji-Chun Lee; ByoungJae Kong; Jae Youl Cho; Keejung Yoon; Cheol-Su Shin; Jin-Ho Seo; Sung-Gun Kim; Dae-Hyuk Kweon
January 2012
International Journal of Nanomedicine;2012, Vol. 7, p2805
Academic Journal
No abstract available.


Related Articles

  • Assembly of Bio-Nanoparticles for Double Controlled Drug Release. Huang, Wei; Zhang, Jianfei; Dorn, Harry C.; Zhang, Chenming // PLoS ONE;Sep2013, Vol. 8 Issue 9, p1 

    A critical limiting factor of chemotherapy is the unacceptably high toxicity. The use of nanoparticle based drug carriers has significantly reduced the side effects and facilitated the delivery of drugs. Source of the remaining side effect includes (1) the broad final in vivo distribution of the...

  • Cytotoxic Effect of Paclitaxel Incorporated in Nanoparticles Based on Lactic and Glycolic Acid Copolymer. Bojat, V.; Baranov, D.; Oganesyan, E.; Hamdy, Y.; Balaban'yan, V.; Alyautdin, R. // Bulletin of Experimental Biology & Medicine;Jul2011, Vol. 151 Issue 3, p340 

    Paclitaxel dosage form on nanoparticles of 200-300 nm based on lactic and glycolic acid copolymer was obtained by the co-precipitation method. The possibility of controlled release of paclitaxel at pH 7.4 for 24 h was studied in vitro. Studies on Jurkat/WT human T-lymphoblastic leukemia cells...

  • In-vitro Physico-chemical evaluation of Biopolymeric Nanoparticles. Chanchal, Abhishek; Akhtar Husain, Syed; Kamra Verma, Anita // Journal of Pharmacy Research;2012, Vol. 5 Issue 8, p4042 

    We propose to evaluate the release pattern of paclitaxel (PTX) and their cellular uptake by breast cancer adenocarcinoma cell line MCF-7 and HEK cells to evaluate the internalization of the nanoparticles. Paclitaxel is most promising treatment for neo-hyperplasia owing to its broad spectrum...

  • Novel ZnO hollow-nanocarriers containing paclitaxel targeting folate-receptors in a malignant pH-microenvironment for effective monitoring and promoting breast tumor regression. Puvvada, Nagaprasad; Rajput, Shashi; Kumar, B.N. Prashanth; Mandal, Mahitosh; Sarkar, Siddik; Konar, Suraj; Pathak, Amita; Brunt, Keith R.; Rao, Raj R.; Mazumdar, Abhijit; Das, Swadesh K.; Fisher, Paul B.; Basu, Ranadhir // Scientific Reports;7/10/2015, p11760 

    Low pH in the tumor micromilieu is a recognized pathological feature of cancer. This attribute of cancerous cells has been targeted herein for the controlled release of chemotherapeutics at the tumour site, while sparing healthy tissues. To this end, pH-sensitive, hollow ZnO-nanocarriers loaded...

  • Enabling Anticancer Therapeutics by Nanoparticle Carriers: The Delivery of Paclitaxel. Yongjin Liu; Bin Zhang; Bing Yan // International Journal of Molecular Sciences;Jul2011, Vol. 12 Issue 7, p4395 

    Anticancer drugs, such as paclitaxel (PTX), are indispensable for the treatment of a variety of malignancies. However, the application of most drugs is greatly limited by the low water solubility, poor permeability, or high efflux from cells. Nanoparticles have been widely investigated to enable...

  • Nanoparticles of Biodegradable Polymers for Clinical Administration of Paclitaxel. Si-Shen Feng; Li Mu; Khin Yin Win, Yoshihiro; Guofeng Huang, Yoshihiro // Current Medicinal Chemistry;Feb2004, Vol. 11 Issue 4, p413 

    Paclitaxel is one of the best antineoplastic drugs found from nature in the past decades, which has been found effective against a wide spectrum of cancers including ovarian cancer, breast cancer, small and non small cell lung cancer, colon cancer, head and neck cancer, multiple myeloma,...

  • Controlled release of Capreomycin sulfate from pH-responsive nanocapsules. Loiko, Olessya P.; van Herk, Alex M.; Ali, Syed I.; Burkeev, Meiram Zh.; Tazhbayev, Yerkeblan M.; Zhaparova, Lyazzat Zh. // e-Polymers;Aug2013, Vol. 13 Issue 1, p189 

    The synthesis of polymeric nanocapsules loaded with the antituberculosis drug Capreomycin sulphate is presented in this work. The pHresponsive polymeric nanocapsules were successfully synthesized using the RAFT-based vesicle templating approach in the presence of Capreomycin sulphate. Anionic...

  • Polymer-tethered pH-sensitive Magnetic Nanoparticles for Targeted Delivery of Anti-cancer Drug. Yueqing Shen; Menglu Pu; Wei Jiang // Advanced Materials Research;2014, Vol. 936, p723 

    Efficient delivery of drug to tumor cells is one of the crucial issues in cancer therapy. This letter addresses for the first time that poly(acrylic acid) (PAA), a pH-sensitive polymer, is tethered to the surface of the nanoparticles by chemical grafting. The release rates of doxorubicin (DOX)...

  • Efficient pH Dependent Drug Delivery to Target Cancer Cells by Gold Nanoparticles Capped with Carboxymethyl Chitosan. Madhusudhan, Alle; Reddy, Gangapuram Bhagavanth; Venkatesham, Maragoni; Veerabhadram, Guttena; Kumar, Dudde Anil; Natarajan, Sumathi; Ming-Yeh Yang; Anren Hu; Singh, Surya S. // International Journal of Molecular Sciences;May2014, Vol. 15 Issue 5, following p8216 

    Doxorubicin (DOX) was immobilized on gold nanoparticles (AuNPs) capped with carboxymethyl chitosan (CMC) for effective delivery to cancer cells. The carboxylic group of carboxymethyl chitosan interacts with the amino group of the doxorubicin (DOX) forming stable, non-covalent interactions on the...

  • Endogenous lung surfactant inspired pH responsive nanovesicle aerosols: Pulmonary compatible and site-specific drug delivery in lung metastases. Joshi, Nitin; Shirsath, Nitesh; Singh, Ankur; Joshi, Kalpana S.; Banerjee, Rinti // Scientific Reports;11/21/12014, p1 

    Concerns related to pulmonary toxicity and non-specificity of nanoparticles have limited their clinical applications for aerosol delivery of chemotherapeutics in lung cancer. We hypothesized that pulmonary surfactant mimetic nanoparticles that offer pH responsive release specifically in tumor...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics