TITLE

Chemical coupling of thiolated chitosan to preformed liposomes improves mucoadhesive properties

AUTHOR(S)
Gradauer, Kerstin; Vonach, Caroline; Leitinger, Gerd; Kolb, Dagmar; Fröhlich, Eleonore; Roblegg, Eva; Bernkop-Schnürch, Andreas; Prassl, Ruth
PUB. DATE
January 2012
SOURCE
International Journal of Nanomedicine;2012, Vol. 7, p2523
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
No abstract available.
ACCESSION #
82508990

 

Related Articles

  • Core shell methyl methacrylate chitosan nanoparticles: In vitro mucoadhesion and complement activation. Talaei, F.; Azhdarzadeh, M.; Hashemi Nasel, H.; Moosavi, M.; Foroumadi, A.; Dinarvand, R.; Atyabi, F. // DARU;Autumn2011, Vol. 19 Issue 4, p257 

    Background and the purpose of the study: Studies show that chitosan nanoparticles increase mucoadhesivity and penetration of large molecules across mucosal surface. The aim of the present study was to investigate the use of thiolated chitosan in the development of polysaccharide-coated...

  • Pectosomes and Chitosomes as Delivery Systems for Metronidazole: The One-Pot Preparation Method. Andersen, Toril; Vanić, Željka; Flaten, Gøril Eide; Mattsson, Sofia; Tho, Ingunn; Škalko-Basnet, Nataša // Pharmaceutics;Sep2013, Vol. 5 Issue 3, p445 

    Mucoadhesive liposomes offer a potential for improved residence time of liposomal systems targeting contact with mucosal tissues, such as in buccal, oral, colon, and vaginal drug delivery. Most of the currently available methods rely on the coating of preformed liposomes by various mucoadhesive...

  • Preparation and comparison of chitosan nanoparticles with different degrees of glutathione thiolation. P., Yousefpour; F., Atyabi; R., Dinarvand; E., Vasheghani-Farahani // DARU;2011, Vol. 19 Issue 5, p367 

    Background: Chitosan has gained considerable attentions as a biocompatible carrier to improve delivery of active agents. Application of this vehicle in the form of nanoparticle could profit advantages of nanotechnology to increase efficacy of active agents. The purpose of this study was to...

  • Thiolated Chitosan/DNA Nanocomplexes Exhibit Enhanced and Sustained Gene Delivery. Dongwon Lee; Weidong Zhang; Shawna Shirley; Xiaoyuan Kong; Gary Hellermann; Richard Lockey; Shyam Mohapatra // Pharmaceutical Research;Jan2007, Vol. 24 Issue 1, p157 

    AbstractPurpose??Thiolated chitosan appears to possess enhanced mucoadhesiveness and cell penetration properties, however, its potential in gene-drug delivery remains unknown. Herein, we report on a highly effective gene delivery system utilizing a 33-kDa thiol-modified chitosan...

  • Synthesis and characterization of thiolated carboxymethyl chitosan-graft-cyclodextrin nanoparticles as a drug delivery vehicle for albendazole. Alamdarnejad, Ghazaleh; Sharif, Alireza; Taranejoo, Shahrouz; Janmaleki, Mohsen; Kalaee, Mohammad; Dadgar, Mohsen; Khakpour, Mazyar // Journal of Materials Science: Materials in Medicine;Aug2013, Vol. 24 Issue 8, p1939 

    A new strategy for the synthesis of thiolated carboxymethyl chitosan-g-cyclodextrin nanoparticles by an ionic-gelation method is presented. The synthetic approach was based on the utilization of 1,6-hexamethylene diisocyanate during cyclodextrin grafting onto carboxymethyl chitosan. The use of...

  • The Counterbalanced Effect of Size and Surface Properties of Chitosan-Coated poly(isobutylcyanoacrylate) Nanoparticles on Mucoadhesion Due to Pluronic F68 Addition. Petit, Bénédicte; Bouchemal, Kawthar; Vauthier, Christine; Djabourov, Madeleine; Ponchel, Gilles // Pharmaceutical Research;Apr2012, Vol. 29 Issue 4, p943 

    Purpose: To evaluate of the effect of size and surface characteristics of poly(isobutylcyanoacrylate) nanoparticles coated with pluronic F68 and thiolated chitosan on mucoadhesion. Methods: Nanoparticles were obtained by radical emulsion polymerization in presence of different amounts of F68...

  • Chitosan: A Versatile Biomedical Polymer. Cui, Zhanwu; Nair, Lakshmi S. // Recent Patents on Biomedical Engineering;Nov2010, Vol. 3 Issue 3, p129 

    Chitosan is a cationic polysaccharide derived from Chitin, a renewable natural polymer second in abundance to cellulose. Chitosan is one of the most preferred biomaterials for developing wound dressings, tissue engineering scaffolds and drug delivery vehicles due to its mucoadhesivity,...

  • The Effect of β-Glycerophosphate Crosslinking on Chitosan Cytotoxicity and Properties of Hydrogels for Vaginal Application. Szymańska, Emilia; Sosnowska, Katarzyna; Miltyk, Wojciech; Rusak, Małgorzata; Basa, Anna; Winnicka, Katarzyna // Polymers (20734360);2015, Vol. 7 Issue 11, p2223 

    Mucoadhesive gelling systems based on chitosan and chitosan/-glycerophosphate (β-GP) were developed in order to increase clotrimazole residence time in the vaginal cavity. Ex vivo mucoadhesiveness using porcine vaginal mucosa followed with mechanical, viscoelastic, and swelling properties of...

  • A novel method to chemically bind thiazolidine-2,4-dione through cross-linked chitosan nanoparticles using malanodialdehyde as a cross-linker. Singh, Prashant; Kumari, Kamlesh; Tomar, Vartika; Samim, Mohd.; Patel, Rajan; Mehrotra, Gopal Kumar; Dubey, Monica; Pandey, Narendra Deo; Katyal, Anju // Canadian Journal of Chemistry;Nov2011, Vol. 89 Issue 11, p1332 

    Chitosan is a biodegradable natural polymer with great potential for pharmaceutical applications because of its biocompatibility, high charge density, nontoxicity and mucoadhesion. It has been shown that it not only improves the dissolution of poorly soluble drugs but also exerts a significant...

  • Synthesis of Thiolated Alginate and Evaluation of Mucoadhesiveness, Cytotoxicity and Release Retardant Properties. JINDAL, A. B.; WASNIK, M. N.; NAIR, HEMA A. // Indian Journal of Pharmaceutical Sciences;Nov/Dec2010, Vol. 72 Issue 6, p766 

    Modification of polymers by covalent attachment of thiol bearing pendant groups is reported to impart many beneficial properties to them. Hence in the present study, sodium alginate-cysteine conjugate was synthesized by carbodiimide mediated coupling under varying reaction conditions and the...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics