TITLE

Transferrin-PEG-PE modified dexamethasone conjugated cationic lipid carrier mediated gene delivery system for tumor-targeted transfection

AUTHOR(S)
Wei Wang; Fang Zhou; Linfu Ge; Ximin Liu; Fansheng Kong
PUB. DATE
January 2012
SOURCE
International Journal of Nanomedicine;2012, Vol. 7, p2513
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
No abstract available.
ACCESSION #
82508988

 

Related Articles

  • Protamine-Modified DDAB Lipid Vesicles Promote Gene Transfer in the Presence of Serum1. Mizuarai, Shinji; Ono, Ken-ichiro; You, Jun; Kamihira, Masamichi; Iijima, Shinji // Journal of Biochemistry;2001, Vol. 129 Issue 1, p125 

    Cationic lipid vesicle-mediated gene transfer has become common for in vitro gene delivery. However, the transfection efficiency is often impaired by serum. DDAB (dime-thyldioctadecyl ammonium bromide) lipid vesicle-mediated gene transfer, which we previously reported, has the same problem. To...

  • Progress in Cationic Lipid-Mediated Gene Transfection: A Series of Bio-Inspired Lipids as an Example. Montier, Tristan; Benvegnu, Thierry; Jaffr�s, Paul-Alain; Yaouanc, Jean-Jacques; Lehn, Pierre // Current Gene Therapy;Oct2008, Vol. 8 Issue 5, p296 

    Over the last several years, various gene delivery systems have been developed for gene therapy applications. Although viral vector-based gene therapy has led to the greatest achievements in animal and human studies, synthetic nonviral vectors have also been developed as they offer several...

  • Cationic Transfection Lipids. Dexi Liu, Arabinda; Tan Ren, Arabinda; Xiang Gao // Current Medicinal Chemistry;Jul2003, Vol. 10 Issue 14, p1307 

    This review focuses on the recent developments in study of cationic lipids as carriers for DNA delivery. Emphasis is placed on a class of compounds as exemplifies by their similarity in structures and transfection activities. The technical aspects are also reviewed on how to prepare DNA-lipid...

  • Recent Patents in Cationic Lipid Carriers for Delivery of Nucleic Acids. Koynova, Rumiana; Tenchov, Boris // Recent Patents on DNA & Gene Sequences;Apr2011, Vol. 5 Issue 1, p8 

    Gene therapy is a medical technique intended for treatment of disorders caused by defective, missing, or overexpressing genes. Efficient delivery vectors are necessary in order to transport genetic material to the target cells. Such vectors include viral and non-viral carriers. Viral vectors...

  • Enhanced Gene Delivery to HER-2-Overexpressing Breast Cancer Cells by Modified Immunolipoplexes Conjugated with the Anti-HER-2 Antibody. Chien-Hsin Lee; Hsiao, Michael; Yun-Long Tseng; Fu-Hsiung Chang // Journal of Biomedical Science;May/Jun2003, Vol. 10 Issue 3, p337 

    Cationic liposome-mediated gene delivery to tumors has met with only limited success due to the low transfection efficiency and lack of target specificity. We developed a gene delivery system for HER-2-overexpressing cells by adding modified anti-HER-2 Fab' fragments to liposome/ DNA complexes...

  • Folate-Equipped Nanolipoplexes Mediated Efficient Gene Transfer into Human Epithelial Cells. Mornet, Emmanuel; Carmoy, Nathalie; Lainé, Céline; Lemiègre, Loïc; Gall, Tony Le; Laurent, Isabelle; Marianowski, Remi; Férec, Claude; Lehn, Pierre; Benvegnu, Thierry; Montier, Tristan // International Journal of Molecular Sciences;Jan2013, Vol. 14 Issue 1, p1477 

    Since recombinant viral vectors have been associated with serious side effects, such as immunogenicity and oncogenicity, synthetic delivery systems represent a realistic alternative for achieving efficacy in gene therapy. A major challenge for non-viral nanocarriers is the optimization of...

  • Nature as a source of inspiration for cationic lipid synthesis. Benoit Barteau // Genetica;Feb2010, Vol. 138 Issue 2, p153 

    Abstract  Synthetic gene delivery systems represent an attractive alternative to viral vectors for DNA transfection. Cationic lipids are one of the most widely used non-viral vectors for the delivery of DNA into cultured cells and are easily synthesized, leading to a large...

  • The Design of Cationic Lipids for Gene Delivery. Martin, B.; Sainlos, M.; Aissaoui, A.; Oudrhiri, N.; Hauchecorne, M.; Vigneron, J.- P.; Lehn, J.- M.; Lehn, P. // Current Pharmaceutical Design;Feb2005, Vol. 11 Issue 3, p375 

    Synthetic gene delivery vectors are gaining increasing importance in gene therapy as an alternative to recombinant viruses. Among the various types of non-viral vectors, cationic lipids are especially attractive as they can be prepared with relative ease and extensively characterised. Further,...

  • Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis. Alam, Md Rowshon; Dixit, Vidula; Kang, Hyunmin; Li, Zi-Bo; Chen, Xiaoyuan; Trejo, JoAnn; Fisher, Michael; Juliano, Rudy L. // Nucleic Acids Research;2008, Vol. 36 Issue 8, p2764 

    We describe the synthesis and characterization of a 5' conjugate between a 2'-O-Me phosphorothioate antisense oligonucleotide and a bivalent RGD (arginine�glycine�aspartic acid) peptide that is a high-affinity ligand for the av�3 integrin. We used av�3-positive melanoma cells...

  • Cationic Polymer Optimization for Efficient Gene Delivery. Xiaoli Sun; Na Zhang // Mini Reviews in Medicinal Chemistry;Feb2010, Vol. 10 Issue 2, p108 

    The polyplexes which are formed between cationic polymers and DNA through electrostatic interactions and thus known as polycation/DNA complexes, are by far the most widely used non-viral gene delivery vectors. Many factors such as molecular weight, surface charge, charge density, hydrophilicity...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics