Poly(L-histidine)-tagged 5-aminolevulinic acid prodrugs: new photosensitizing precursors of protoporphyrin IX for photodynamic colon cancer therapy

Johnson, Renjith P.; Chung, Chung-Wook; Jeong, Young-Il; Kang, Dae Hwan; Suh, Hongsuk; II Kim
January 2012
International Journal of Nanomedicine;2012, Vol. 7, p2497
Academic Journal
No abstract available.


Related Articles

  • Photodynamic Therapy Using Systemic Administration of 5-Aminolevulinic Acid and a 410-nm Wavelength Light-Emitting Diode for Methicillin-Resistant Staphylococcus aureus-Infected Ulcers in Mice. Morimoto, Kuniyuki; Ozawa, Toshiyuki; Awazu, Kunio; Ito, Nobuhisa; Honda, Norihiro; Matsumoto, Sohkichi; Tsuruta, Daisuke // PLoS ONE;Aug2014, Vol. 9 Issue 8, p1 

    Bacterial resistance to antibiotics has become a worldwide problem. One potential alternative for bacterial control is photodynamic therapy. 5-aminolevulinic acid is a natural precursor of the photosensitizer protoporphyrin IX. Relatively little is known about the antibacterial efficacy of...

  • Photodynamic Therapy and Topical Aminolevulinic Acid: An Overview. Gupta, Aditya K.; Ryder, Jennifer E. // American Journal of Clinical Dermatology;2003, Vol. 4 Issue 10, p699 

    Photodynamic therapy is a non-invasive technique used in the treatment of skin diseases which has various advantages, one being the ability to localize treatment to the area being treated, which is common among most photosensitizers. Aminolevulinic acid is a prodrug that is metabolized...

  • Topical Methyl Aminolevulinate: A Viewpoint by Sally H. Ibbotson. Ibbotson, Sally H. // American Journal of Clinical Dermatology;2004, Vol. 5 Issue 2, p138 

    Offers information on the application of methyl 5-aminolevulinic acid (MAL) photodynamic therapy, a precursor of the photosentisizer protoporphyrin IX, in the treatment of basal cell carcinoma. Findings of studies on the preparation of MAL; Clinical effectiveness of MAL photodynamic therapy;...

  • Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer. Wachowska, Małgorzata; Muchowicz, Angelika; Firczuk, Małgorzata; Gabrysiak, Magdalena; Winiarska, Magdalena; Wańczyk, Małgorzata; Bojarczuk, Kamil; Golab, Jakub // Molecules;May2011, Vol. 16 Issue 5, p4140 

    Aminolevulinic acid (ALA) is an endogenous metabolite normally formed in the mitochondria from succinyl-CoA and glycine. Conjugation of eight ALA molecules yields protoporphyrin IX (PpIX) and finally leads to formation of heme. Conversion of PpIX to its downstream substrates requires the...

  • PpIX Fluorescence Kinetics and Increased Skin Damage after Intracutaneous Injection of 5-Aminolevulinic Acid and Repeated Illumination. Thissen, Monique R; de Blois, Mieke W; Robinson, Dominic J; de Bruijn, Henriette S; Dutrieux, Richard P; Star, Willem M; Neumann, H.A. Martino // Journal of Investigative Dermatology;Feb2002, Vol. 118 Issue 2, p239 

    Photodynamic therapy with topically applied 5-aminolevulinic acid is used successfully for superficial skin lesions. The results for thicker, nodular lesions are less favorable. The method of aminolevulinic acid administration, the concentrations of aminolevulinic acid, and the irradiation...

  • Photodynamic and Antibiotic Therapy in Combination to Fight Biofilms and Resistant Surface Bacterial Infections. Barra, Federica; Roscetto, Emanuela; Soriano, Amata A.; Vollaro, Adriana; Postiglione, Ilaria; Pierantoni, Giovanna Maria; Palumbo, Giuseppe; Catania, Maria Rosaria // International Journal of Molecular Sciences;Sep2015, Vol. 16 Issue 9, p20417 

    Although photodynamic therapy (PDT), a therapeutic approach that involves a photosensitizer, light and O2, has been principally considered for the treatment of specific types of cancers, other applications exist, including the treatment of infections. Unfortunately, PDT does not always guarantee...

  • Wavelength Dependency of Photodynamic Effects After Sensitization with 5-Aminolevulinic Acid In Vitro and In Vivo. Szeimies, Rolf-Markus; Abels, Christoph; Fritsch, Clemens; Karrer, Sigrid; Stinbach, Pia; Bäumler, Wolfgang; Goerz, Günter; Goetz, Alwin E.; Landthaler, Michael // Journal of Investigative Dermatology;Nov95, Vol. 105 Issue 5, p672 

    A promising new therapeutic modality for skin cancer, administration of the heme precursor 5-aminolevulinic acid followed by light irradiation, is known as photodynamic therapy. Photofrin, the only clinically approved sensitizer, has an absorption maximum at 630 nm, the wavelength used in most...

  • Aminolevulinic Acid-Based Tumor Detection and Therapy: Molecular Mechanisms and Strategies for Enhancement. Xue Yang; Palasuberniam, Pratheeba; Kraus, Daniel; Chen, Bin // International Journal of Molecular Sciences;2015, Vol. 16 Issue 10, p25865 

    Aminolevulinic acid (ALA) is the first metabolite in the heme biosynthesis pathway in humans. In addition to the end product heme, this pathway also produces other porphyrin metabolites. Protoporphyrin (PpIX) is one heme precursor porphyrin with good fluorescence and photosensitizing activity....

  • Oxygen Availability for Porphyrin Biosynthesis Enzymes Determines the Production of Protoporphyrin IX (PpIX) during Hypoxia. Otsuka, Shimpei; Matsumoto, Kentaro; Nakajima, Motowo; Tanaka, Tohru; Ogura, Shun-ichiro // PLoS ONE;12/30/2015, Vol. 10 Issue 12, p1 

    5-Aminolevulinic acid (ALA), a precursor of porphyrin, is specifically converted to the fluorescent substance protoporphyrin IX (PpIX) in tumors to be used as a prodrug for photodynamic therapy and diagnosis. Hypoxia, a common feature of solid tumors, decreases the efficacy of ALA-based...

  • Transporter-Mediated Drug Interaction Strategy for 5-Aminolevulinic Acid (ALA)-Based Photodynamic Diagnosis of Malignant Brain Tumor: Molecular Design of ABCG2 Inhibitors. Ishikawa, Toshihisa; Takahashi, Kenkichi; Ikeda, Naokado; Kajimoto, Yoshinaga; Hagiya, Yuichiro; Ogura, Shun-ichiro; Miyatake, Shin-ichi; Kuroiwa, Toshihiko // Pharmaceutics;Sep2011, Vol. 3 Issue 3, p615 

    Photodynamic diagnosis (PDD) is a practical tool currently used in surgical operation of aggressive brain tumors, such as glioblastoma. PDD is achieved by a photon-induced physicochemical reaction which is induced by excitation of protoporphyrin IX (PpIX) exposed to light. Fluorescence-guided...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics