TITLE

Reversing multidrug resistance in breast cancer cells by silencing ABC transporter genes with nanoparticle-facilitated delivery of target siRNAs

AUTHOR(S)
Yong Tsuey Li; Ming Jang Chua; Kunnath, Anil Philip; Hoque, Ezharul; Chowdhury
PUB. DATE
January 2012
SOURCE
International Journal of Nanomedicine;2012, Vol. 7, p2473
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
No abstract available.
ACCESSION #
82508985

 

Related Articles

  • Silencing of ETS1 reverses adriamycin resistance in MCF-7/ADR cells via downregulation of MDR1. Jinrong Wei; Yong Zhou; Guo-Qin Jiang; Dong Xiao // Cancer Cell International;2014, Vol. 14 Issue 1, p1 

    Background Clinical resistance to chemotherapeutic agents is one of the major hindrances in the treatment of human cancers. Erythroblastosis virus E26 oncogene homolog 1 (ETS1) is involved in the drug resistance of various cancer cells, and is overexpressed in drug-resistant human breast cancer...

  • Small Interfering RNA. Nambudiri, Vinod E; Widlund, Hans R // Journal of Investigative Dermatology;Dec2013, Vol. 133 Issue 12, pe15 

    The article focuses on the applications of small interfering RNA (siRNA) techniques for gene silencing and targeted drug delivery. It states that siRNAs work on the principle of complementary base pairing between nucleic acids. It mentions that the targets of siRNAs includes mRNA transcripts of...

  • RPN2 gene confers docetaxel resistance in breast cancer. Honma, Kimi; Iwao-Koizumi, Kyoko; Takeshita, Fumitaka; Yamamoto, Yusuke; Yoshida, Teruhiko; Nishio, Kazuto; Nagahara, Shunji; Kato, Kikuya; Ochiya, Takahiro // Nature Medicine;Sep2008, Vol. 14 Issue 9, p939 

    Drug resistance acquired by cancer cells has led to treatment failure. To understand the regulatory network underlying docetaxel resistance in breast cancer cells and to identify molecular targets for therapy, we tested small interfering RNAs (siRNAs) against 36 genes whose expression was...

  • Targeted Gene Silencing by Small Interfering RNA-Based Knock-Down Technology. J. Zhang; Z. C. Hua, Rudolf // Current Pharmaceutical Biotechnology;Feb2004, Vol. 5 Issue 1, p1 

    RNA interference (RNAi) has emerged as a powerful tool for the silencing of gene expression in animals and plants. RNAi is mediated by approximately 21-nt small interfering RNAs (siRNAs), which are originally produced from larger double stranded RNAs (dsRNAs) in vivo through the action of Dicer....

  • The siRNA targeted to mdr1b and mdr1a mRNAs in vivo sensitizes murine lymphosarcoma to chemotherapy. Patutina, Olga A.; Mironova, Nadezda L.; Popova, Nelly A.; Kaledin, Vasily I.; Nikolin, Valery P.; Vlassov, Valentin V.; Zenkova, Marina A. // BMC Cancer;2010, Vol. 10, p204 

    Background: One of the main obstacles for successful cancer polychemotherapy is multiple drug resistance phenotype (MDR) acquired by tumor cells. Currently, RNA interference represents a perspective strategy to overcome MDR via silencing the genes involved in development of this deleterious...

  • Association of ABCB1, β tubulin I, and III with multidrug resistance of MCF7/DOC subline from breast cancer cell line MCF7. Li, Wentao; Zhai, Baoping; Zhi, Hui; Li, Yuhong; Jia, Linjiao; Ding, Chao; Zhang, Bin; You, Wei // Tumor Biology;Sep2014, Vol. 35 Issue 9, p8883 

    Docetaxel is a first-line chemotherapeutic agent for treating advanced breast cancer. The development of chemoresistance or multidrug resistance (MDR), however, results in breast cancer chemotherapy failure. This study aims to explore the molecular mechanisms underlying docetaxel-resistance in...

  • Paclitaxel resistance in MCF-7/PTX cells is reversed by paeonol through suppression of the SET/phosphatidylinositol 3-kinase/Akt pathway. WEIPENG ZHANG; JIANGXIA CAI; SIYING CHEN; XIAOWEI ZHENG; SASA HU; WEIHUA DONG; JUN LU; JIANFENG XING; YALIN DONG // Molecular Medicine Reports;2015, Vol. 12 Issue 1, p1506 

    Breast cancer is one of the most prevalent types of malignant tumor. Paclitaxel is widely used in the treatment of breast cancer; however, the major problem contributing to the failure of chemotherapy in breast cancer is the development of drug resistance. Therefore, it is necessary to identify...

  • Chemosensitization of cancer cells by siRNA using targeted nanogel delivery. Dickerson, Erin B.; Blackburn, William H.; Smith, Michael H.; Kapa, Laura B.; Lyon, L. Andrew; McDonald, John F. // BMC Cancer;2010, Vol. 10, Special section p1 

    Background: Chemoresistance is a major obstacle in cancer treatment. Targeted therapies that enhance cancer cell sensitivity to chemotherapeutic agents have the potential to increase drug efficacy while reducing toxic effects on untargeted cells. Targeted cancer therapy by RNA interference...

  • Reversal of Multidrug Resistance by the Chinese Medicine Yiqi Jianpi Huaji Decoction and the Mechanism of Action in Human Gastric Cancer SGC7901/VCR Cells. Wei-Bing Li; Yang Li; Chen Yu; Yong-Ming He // Evidence-based Complementary & Alternative Medicine (eCAM);2015, p1 

    Yiqi Jianpi Huaji Decoction (YJHD), a traditional Chinese medicinal formula composed of twelve ingredients, has recently been reported to have a good clinical curative effect. The purpose of the present study was to evaluate the effects of YJHD on SGC7901/VCR gastric cancer cells and to...

  • Reversal of Multidrug Resistance by the Chinese Medicine Yiqi Jianpi Huaji Decoction and the Mechanism of Action in Human Gastric Cancer SGC7901/VCR Cells. Li, Wei-Bing; Li, Yang; Yu, Chen; He, Yong-Ming // Evidence-based Complementary & Alternative Medicine (eCAM);2/2/2015, Vol. 2015, p1 

    Yiqi Jianpi Huaji Decoction (YJHD), a traditional Chinese medicinal formula composed of twelve ingredients, has recently been reported to have a good clinical curative effect. The purpose of the present study was to evaluate the effects of YJHD on SGC7901/VCR gastric cancer cells and to...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics