Exosome mimetics: a novel class of drug delivery systems

Kooijmans, Sander A. A.; Vader, Pieter; van Dommelen, Susan M.; van Solinge, Wouter W.; Schiffelers, Raymond M.
January 2012
International Journal of Nanomedicine;2012, Vol. 7, p1525
Academic Journal
No abstract available.


Related Articles

  • Integrating Protein Engineering and Bioorthogonal Click Conjugation for Extracellular Vesicle Modulation and Intracellular Delivery. Wang, Ming; Altinoglu, Sarah; Takeda, Yuji S.; Xu, Qiaobing // PLoS ONE;11/3/2015, Vol. 10 Issue 10, p1 

    Exosomes are small, cell-secreted vesicles that transfer proteins and genetic information between cells. This intercellular transmission regulates many physiological and pathological processes. Therefore, exosomes have emerged as novel biomarkers for disease diagnosis and as nanocarriers for...

  • Exosomes as nanocarriers for siRNA delivery: paradigms and challenges. Shahabipour, Fahimeh; Banach, Maciej; Sahebkar, Amirhossein // Archives of Medical Science;2016, Vol. 12 Issue 6, p1324 

    Exosomes are nano-sized vesicles that facilitate intercellular communications through carrying genetic materials and functional biomolecules. Owing to their unique size and structure, exosomes have emerged as a useful tool to overcome the limitations of siRNA delivery. The use of exosomes as...

  • Specific Transfection of Inflamed Brain by Macrophages: A New Therapeutic Strategy for Neurodegenerative Diseases. Haney, Matthew J.; Zhao, Yuling; Harrison, Emily B.; Mahajan, Vivek; Ahmed, Shaheen; He, Zhijian; Suresh, Poornima; Hingtgen, Shawn D.; Klyachko, Natalia L.; Mosley, R. Lee; Gendelman, Howard E.; Kabanov, Alexander V.; Batrakova, Elena V. // PLoS ONE;Apr2013, Vol. 8 Issue 4, p1 

    The ability to precisely upregulate genes in inflamed brain holds great therapeutic promise. Here we report a novel class of vectors, genetically modified macrophages that carry reporter and therapeutic genes to neural cells. Systemic administration of macrophages transfected ex vivo with a...

  • Ikaria recalls drug delivery system. McCarty, Mark // Medical Device Daily;8/26/2010, Vol. 14 Issue 166, p8 

    The article reports on the class 1 recall of the Inomax drug delivery system by Ikaria.

  • Elucidation of Exosome Migration Across the Blood-Brain Barrier Model In Vitro. Chen, Claire; Liu, Linan; Ma, Fengxia; Wong, Chi; Guo, Xuning; Chacko, Jenu; Farhoodi, Henry; Zhang, Shirley; Zimak, Jan; Ségaliny, Aude; Riazifar, Milad; Pham, Victor; Digman, Michelle; Pone, Egest; Zhao, Weian // Cellular & Molecular Bioengineering;Dec2016, Vol. 9 Issue 4, p509 

    The delivery of therapeutics to the central nervous system remains a major challenge in part due to the presence of the blood-brain barrier (BBB). Recently, cell-derived vesicles, particularly exosomes, have emerged as an attractive vehicle for targeting drugs to the brain, but whether or how...

  • Exosome in Tumour Microenvironment: Overview of the Crosstalk between Normal and Cancer Cells. Roma-Rodrigues, Catarina; Fernandes, Alexandra R.; Baptista, Pedro Viana // BioMed Research International;2014, Vol. 2014, p1 

    Cancer development is amultistep process in which exosomes play important roles. Exosomes are small vesicles formed in vesicular bodies in the endosomal network. The major role of exosomes seems to be the transport of bioactive molecules between cells. Depending on the cell of origin, exosomes...

  • Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells. Ohno, Shin-ichiro; Takanashi, Masakatsu; Sudo, Katsuko; Ueda, Shinobu; Ishikawa, Akio; Matsuyama, Nagahisa; Fujita, Koji; Mizutani, Takayuki; Ohgi, Tadaaki; Ochiya, Takahiro; Gotoh, Noriko; Kuroda, Masahiko // Molecular Therapy;Jan2013, Vol. 21 Issue 1, p185 

    Despite the therapeutic potential of nucleic acid drugs, their clinical application has been limited in part by a lack of appropriate delivery systems. Exosomes or microvesicles are small endosomally derived vesicles that are secreted by a variety of cell types and tissues. Here, we show that...

  • Exosomes: Specific Intercellular Nano-Shuttles? Barral, Ana Maria; Von Herrath, Matthias G. // Current Immunology Reviews;2005, Vol. 1 Issue 1, p1 

    The term “exosome” was coined in 1981 (Trams et al, Biochim Biophys Acta, 1981, 645:63) when the presence of “exfoliated membrane vesicles with 5'-nucleotidase activity” was first reported. Since then, in the biomedical literature the term exosome has evolved to designate...

  • Exosomes: novel implications in diagnosis and treatment of gastrointestinal cancer. Rahbari, Mohammad; Rahbari, Nuh; Reissfelder, Christoph; Weitz, Juergen; Kahlert, Christoph // Langenbeck's Archives of Surgery;Dec2016, Vol. 401 Issue 8, p1097 

    Background: Amongst all cancer subtypes, gastrointestinal tumours are responsible for most cancer-related deaths. In most of the cases, the limitation of the prognosis of patients with malignant gastrointestinal tumours can be attributed to delayed diagnosis of the disease. In the last decade,...

  • Exosome removal as a therapeutic adjuvant in cancer. Marleau, Annette M.; Chien-Shing Chen; Joyce, James A.; Tullis, Richard H. // Journal of Translational Medicine;2012, Vol. 10 Issue 1, p134 

    Exosome secretion is a notable feature of malignancy owing to the roles of these nanoparticles in cancer growth, immune suppression, tumor angiogenesis and therapeutic resistance. Exosomes are 30-100 nm membrane vesicles released by many cells types during normal physiological processes. Tumors...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics