A scalable fabrication process of polymer microneedles

Sixing Yang; Yan Feng; Nixiang Chen; Weien Yuan; Tuo Jin
January 2012
International Journal of Nanomedicine;2012, Vol. 7, p1415
Academic Journal
No abstract available.


Related Articles

  • Microneedles deliver medicine through skin without pain.  // Advanced Materials & Processes;Mar2004, Vol. 162 Issue 3, p14 

    Reports on the development by the Georgia Institute of Technology in Atlanta, Georgia of microneedle arrays for delivering drug and vaccines through the skin. Focus of the research on fabricating hollow and solid microneedles from metals, biodegradable polymers, silicon and glass; Ability of...

  • Fabrication of carbon nanotube-polyimide composite hollow microneedles for transdermal drug delivery. Lyon, Bradley; Aria, Adrianus; Gharib, Morteza // Biomedical Microdevices;Dec2014, Vol. 16 Issue 6, p879 

    We introduce a novel method for fabricating hollow microneedles for transdermal drug delivery using a composite of vertically-aligned carbon nanotubes and polyimide. Patterned bundles of carbon nanotubes are used as a porous scaffold for defining the microneedle geometry. Polyimide resin is...

  • Transdermal delivery of cosmetic ingredients using dissolving polymer microneedle arrays. Park, Yonghun; Park, Jeryang; Chu, Gwi; Kim, Kyu; Sung, Jong; Kim, Bumsang // Biotechnology & Bioprocess Engineering;Jun2015, Vol. 20 Issue 3, p543 

    The efficiency of transdermal delivery of cosmetic ingredients is often limited by the outer layer of the skin, known as the stratum corneum, which can prevent diffusion of the cosmetic ingredients through the skin. A polymer microneedle array that dissolves in the skin can enhance the...

  • MICROSTRUCTURING OF SU-8 RESIST FOR MEMS AND BIO-APPLICATIONS. Dey, P. K.; Pramanick, B.; RaviShankar, A.; Ganguly, P.; Das, S. // International Journal on Smart Sensing & Intelligent Systems;Mar2010, Vol. 3 Issue 1, p118 

    Some studies on the fabrication of micro-needles, micro-pillers, and micro-channels using SU-8 negative photoresist for MEMS and bio-applications are reported. The SU-8 processing technology was standardized for the purpose. Micro-pillars were fabricated on SU-8 polymer by soft lithographic...

  • Hollow microneedles for intradermal injection fabricated by sacrificial micromolding and selective electrodeposition. Norman, James; Choi, Seong-O; Tong, Nhien; Aiyar, Avishek; Patel, Samirkumar; Prausnitz, Mark; Allen, Mark // Biomedical Microdevices;Apr2013, Vol. 15 Issue 2, p203 

    Limitations with standard intradermal injections have created a clinical need for an alternative, low-cost injection device. In this study, we designed a hollow metal microneedle for reliable intradermal injection and developed a high-throughput micromolding process to produce metal microneedles...

  • Mass producible and biocompatible microneedle patch and functional verification of its usefulness for transdermal drug delivery. Jin, Chun; Han, Man; Lee, Seung; Choi, Yo // Biomedical Microdevices;Dec2009, Vol. 11 Issue 6, p1195 

    The key issues in the development of a microneedle patch as a tool for transdermal drug delivery are safety and delivery performance in addition to economical production. In this paper, novel fabrication methods for an inexpensive microneedle patch made of biocompatible polymer are reported,...

  • Investigation of Optimal Silk Film Thickness in Silk Microneedle Fabrication. Jiruedee, S.; Luangweera, W.; Sookyu, B.; Patoomvasna, K.; Pimpin, A.; Rattanasumawong, C.; Palaga, T.; Damrongsukkul, S.; Srituravanich, W. // Applied Mechanics & Materials;2015, Vol. 752-753, p177 

    then received wide attention since they can overcome such drawbacks, especially dissolving microneedles. Recently, silk fibroin has been used to fabricate dissolving silk microneedles for transdermal drug delivery at low temperature. In the fabrication process, the quality of the silk...

  • Microneedle Technology for Advanced Drug Delivery: A Review. Rohan, S. Desale; Kalpesh, S. Wagh; Anup, M. Akarte; Dheeraj, T. Baviskar; Dinesh, K. Jain // International Journal of PharmTech Research;Jan-Mar2012, Vol. 4 Issue 1, p181 

    The objective of this review article is to summarize recent data, description results and basic functionality of silicon microneedles array through biodegradable instructions. In order to avoid the main troubles related to drug degradation by gastrointestinal track and their elimination through...

  • Microneedles with Intrinsic Immunoadjuvant Properties: Microfabrication, Protein Stability, and Modulated Release. Andrianov, Alexander; Marin, Alexander; DeCollibus, Daniel // Pharmaceutical Research;Jan2011, Vol. 28 Issue 1, p58 

    Purpose: Intradermal immunization using microneedles requires compatible immunoadjuvant system. To address this challenge, we investigated microneedles coated with polyphosphazene polyelectrolyte, which served both as microfabrication material and an immunoadjuvant compound. Methods: Coated...

  • In Vivo, In Situ Imaging of Microneedle Insertion into the Skin of Human Volunteers Using Optical Coherence Tomography. Coulman, Siôn; Birchall, James; Alex, Aneesh; Pearton, Marc; Hofer, Bernd; O'Mahony, Conor; Drexler, Wolfgang; Považay, Boris // Pharmaceutical Research;Jan2011, Vol. 28 Issue 1, p66 

    Purpose: To gather sub-surface in situ images of microneedle-treated human skin, in vivo, using optical coherence tomography (OCT). This is the first study to utilise OCT to investigate the architectural changes that are induced in skin following microneedle application. Methods: Steel, silicon...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics