Titanium dioxide induces apoptotic cell death through reactive oxygen species-mediated Fas upregulation and Bax activation

Ki-Chun Yoo; Chang-Hwan Yoon; Dongwook Kwon; Kyung-Hwan Hyun; Soo Jung Woo; Rae-Kwon Kim; Eun-Jung Lim; Yongjoon Suh; Min-Jung Kim; Tae Hyun Yoon; Su-Jae Lee
January 2012
International Journal of Nanomedicine;2012, Vol. 7, p1203
Academic Journal
No abstract available.


Related Articles

  • Endomorphins, endogenous opioid peptides, induce apoptosis in human leukemia HL-60 cells. Xin Lin; Qiang Chen; Li-Ying Xue; Xiao-Jun Ma; Rui Wang // Canadian Journal of Physiology & Pharmacology;Nov2004, Vol. 82 Issue 11, p1018 

    Opioids play a role in the apoptosis machinery. We studied the induction of apoptosis in endomorphin 1 (EM1) and endomorphin 2 (EM2), 2 newly isolated endogenous µ-opioid receptor agonists. These endomorphins were able to reduce the viability of cultured HL-60 cells. The antiproliferative...

  • Phyllanthus urinaria Induces Apoptosis in Human Osteosarcoma 143B Cells via Activation of Fas/FasL- and Mitochondria- Mediated Pathways. Hsin-Yi Wu; Tsu-Kung Lin; Hsiao- Mei Kuo; Ya-Ling Huang; Chia-Wei Liou; Pei-Wen Wang; Jiin-Haur Chuang; Sheng-Teng Huang // Evidence-based Complementary & Alternative Medicine (eCAM);2012, Vol. 2012, p1 

    Phyllanthus urinaria (P. urinaria), in this study, was used for the treatment of human osteosarcoma cells, which is one of the tough malignancies with few therapeutic modalities. Herein, we demonstrated that P. urinaria inhibited human osteosarcoma 143B cells growth through an apoptotic...

  • Cell death induced by the Fas/Fas ligand pathway and its role in pathology. Waring, Paul; Müllbacher, Arno // Immunology & Cell Biology;Aug1999, Vol. 77 Issue 4, p312 

    Engagement of the cell death surface receptor Fas by Fas ligand (FasL) results in apoptotic cell death, mediated by caspase activation. Cell death mediated via Fas/FasL interaction is important for homeostasis of cells in the immune system and for maintaining immune-privileged sites in the body....

  • Bufalin Induces Reactive Oxygen Species Dependent Bax Translocation and Apoptosis in ASTC-a-1 Cells. Lei Sun; Tongsheng Chen; Xiaoping Wang; Yun Chen; Xunbin Wei // Evidence-based Complementary & Alternative Medicine (eCAM);Jan2011, Vol. 8 Issue 1, p1 

    Bufalin has been shown to induce cancer cell death through apoptotic pathways. However, the molecular mechanisms are not well understood. In this study, we used the confocal fluorescence microscopy (CFM) to monitor the spatio-temporal dynamics of reactive oxygen species (ROS) production, Bax...

  • Regulation of Intrinsic and Extrinsic Apoptotic Pathways in Osteosarcoma Cells Following Oleandrin Treatment. Yunlong Ma; Bin Zhu; Lei Yong; Chunyu Song; Xiao Liu; Huilei Yu; Peng Wang; Zhongjun Liu; Xiaoguang Liu // International Journal of Molecular Sciences;Nov2016, Vol. 17 Issue 11, following p1 

    Our previous study has reported the anti-tumor effect of oleandrin on osteosarcoma (OS) cells. In the current study, we mainly explored its potential regulation on intrinsic and extrinsic apoptotic pathway in OS cells. Cells apoptosis, reactive oxygen species (ROS) and mitochondrial membrane...

  • Melatonin Is Able to Reduce the Apoptotic Liver Changes Induced by Aging Via Inhibition of the Intrinsic Pathway of Apoptosis. Molpeceres, Virginia; Mauriz, José L.; García-Mediavilla, Marí V.; Gonzá, Paquita; Barrio, Juan P.; González-Gallego, Javier // Journals of Gerontology Series A: Biological Sciences & Medical ;Jul2007, Vol. 62 Issue 7, p687 

    We examined the effect of daily melatonin supplementation on liver apoptosis induced by aging in rats. Young (3-month-old) and aged (24-month-old) Wistar rats were supplemented daily with melatonin in their drinking water (20 mg/L) for 4 weeks. Aged rats showed increases in the liver...

  • Nano-titanium dioxide induces genotoxicity and apoptosis in human lung cancer cell line, A549. Srivastava, RK; Rahman, Q; Kashyap, MP; Singh, AK; Jain, G; Jahan, S; Lohani, M; Lantow, M; Pant, AB // Human & Experimental Toxicology;Feb2013, Vol. 32 Issue 2, p153 

    The increased inhaled application of titanium dioxide nanoparticles (TiO2 NPs) increases the potential pulmonary health risks. The present investigations were carried out to study the TiO2 NPs-induced apoptosis, oxidative stress and genotoxicity in the human lung cancer cell line, A549, a widely...

  • Camptothecin sensitizes androgen-independent prostate cancer cells to anti-Fas-induced apoptosis. Costa-Pereira, A P; Cotter, T G // British Journal of Cancer;5/1/99, Vol. 80 Issue 3/4, p371 

    Despite expressing both Fas and Fas ligand, DU145 and LNCaP prostate cancer cells were resistant to anti-Fas-induced cell death. Resistance to Fas-mediated cytotoxicity could be overcome in DU145, but not in LNCaP, cells by pretreating cells with sublethal doses of cytotoxic drugs, such as...

  • Renal lymphatic ligation aggravates renal dysfunction through induction of tubular epithelial cell apoptosis in mononephrectomized rats. Jing Cheng; Jianping Wang; Yuan-tao Liu; Taoyan Zhang; Aili Sun; Weiwei Wang; Shasha Lv; Shanshan Liu; Guangju Guan // Clinical Nephrology;Feb2013, Vol. 79 Issue 2, p124 

    Aims: To further explore the mechanisms of apoptosis in mononephrectomized rats with renal lymph circulation disorder. Methods: Animals were divided into three groups: rats with left renal lymph ligation and right nephrectomy (KL), rats with only right nephrectomy (KN) and sham-operated rats...

  • Activation-induced cell death: The controversial role of Fas and Fas ligand in immune privilege and tumour counterattack. Maher, Stephen; Toomey, Deirdre; Condron, Claire; Bouchier-Hayes, David // Immunology & Cell Biology;Apr2002, Vol. 80 Issue 2, p131 

    Summary Activation-induced cell death (AICD) is the process by which cells undergo apoptosis in a controlled manner through the interaction of a death factor and its receptor. Programmed cell death can be induced by a number of physiological and pathological factors including Fas (CD95)-Fas...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics