Degradable polyethylenimine derivate coupled to a bifunctional peptide R13 as a new gene-delivery vector

Kehai Liu; Xiaoyu Wang; Wei Fan; Qing Zhu; Jingya Yang; Jing Gao; Shen Gao
January 2012
International Journal of Nanomedicine;2012, Vol. 7, p1149
Academic Journal
No abstract available.


Related Articles

  • 195. Tat Peptide Conjugates of Low Molecular Weight Polyethylenimine as Effective Non-Viral Gene Delivery Vectors. Wang, Shu // Molecular Therapy;Jun2006, Vol. 13, pS76 

    Tat peptide derived from the arginine-rich basic domain of the HIV transactivator of transcription are capable of mediating intracellular delivery of various types of drugs, including large biomolecules and nanoparticulate drug carriers. For gene delivery, several recent publications reported...

  • Vector method applied to multi body coupled rotations. Hedrih, Katica R. (Stevanović); Stamenković, Marija B. // Mathematics in Engineering, Science & Aerospace (MESA);Sep2015, Vol. 6 Issue 3, p345 

    Vector method applied to multi body coupled rotations on the basis of mass moment vectors. Vector expressions for the linear and angular momentum derivatives of multi body's coupled rotations are derived. Mass moment vectors and vector rotators coupled for no intersecting axes and corresponding...

  • Strategies for Design of Non Peptide CCK1R Agonist/Antagonist Ligands. M. Teresa Garcia-Lopez; Rosario Gonzalez-Muniz; Mercedes Martin-Martinez; Rosario Herranz // Current Topics in Medicinal Chemistry;Jun2007, Vol. 7 Issue 12, p1180 

    This review mainly covers last five year literature on CCK1R agonists and antagonists. These CCK1R ligands have been found following the two usual and complementary strategies for drug discovery: rational design based on structure activity relationships on the CCK-7 and CCK-4 peptide sequences...

  • Synthetic DNA-compacting peptides derived from human sequence enhance cationic lipid-mediated gene transfer in vitro and in vivo. Schwartz, B; Ivanov, M-A; Pitard, B; Escriou, V; Rangara, R; Byk, G; Wils, P; Crouzet, J; Scherman, D // Gene Therapy;Feb99, Vol. 6 Issue 2, p282 

    Cationic lipids can deliver genes efficiently in vitro, but are generally inhibited by the presence of serum, and their efficiency in vivo is much lower than in vitro. An attractive strategy is to induce strong DNA compaction by its association with proteins, before addition of lipids. However...

  • P235 Viral-delivered gene therapy for treatment of CPVT. Kurtzwald-Josefson, E; Hochauser, E; Khun, S; Shainberg, A; Aravot, D; Eldar, M; Arad, M // Cardiovascular Research;Jul2014, Vol. 103 Issue suppl_1, pS42 

    Catecholaminergic polymorphic ventriculartachycardia (CPVT) is a lethal human arrhythmia provoked by exercise or emotional stress. It is mediated by abnormal calcium release from the sarcoplasmic reticulum through "leaky" ryanodine channels. Beta-adrenergic blockers are the therapy of choice for...

  • Learning from lentiviruses. Emerman, Michael // Nature Genetics;Jan2000, Vol. 24 Issue 1, p8 

    The advantage that vectors derived from the human immunodeficiency virus offer over other gene-delivery vehicles is their ability to transduce non-proliferative tissues. But a report by Park et al. suggests that HIV-based vectors are not able to infect all non-dividing cells and that host cell...

  • A peptide nucleic acid?nuclear localization signal fusion that mediates nuclear transport of DNA. Brandén, Lars J.; Mohamed, Abdalla J.; Smith, C. I. Edvard // Nature Biotechnology;Aug99, Vol. 17 Issue 8, p784 

    We have combined a peptide nucleic acid (PNA) with the SV40 core nuclear localization signal (NLS), to create a bifunctional PNA-NLS peptide. The PNA-NLS peptide increased the nuclear uptake of oligonucleotides and enhanced the transfection efficacy of plasmids. Gene expression from an enhanced...

  • Design and Evaluation of Histidine-Rich Amphipathic Peptides for siRNA Delivery. Langlet-Bertin, Bérangère; Leborgne, Christian; Scherman, Daniel; Bechinger, Burkhard; Mason, A. James; Kichler, Antoine // Pharmaceutical Research;Jul2010, Vol. 27 Issue 7, p1426 

    Short linear peptides have a high potential for delivering various drugs with therapeutic potential, including nucleic acids. Recently, we have shown that the cationic amphipathic histidine-rich peptide LAH4 (KKALLALALHHLAHLALHLALALKKA) possesses high plasmid DNA delivery capacities. Since such...

  • Design and Development of Degradable Polyethylenimines for Delivery of DNA and Small Interfering RNA: An Updated Review. Cho, Chong-Su // ISRN Materials Science;2012, p1 

    Polyethylenimine (PEI), considered as the most potent and promising alternative carrier to viral vectors, has been studied as the "state of the art" among various polymers for nonviral gene delivery applications for many years. Although PEI-based carrier minimizes the bottlenecks associated with...

  • ER stress affects processing of MHC class I-associated peptides. Granados, Diana P.; Tanguay, Pierre-Luc; Hardy, Marie-Pierre; Caron, Étienne; de Verteuil, Danielle; Meloche, Sylvain; Perreault, Claude // BMC Immunology;2009, Vol. 10, Special section p1 

    Background: Viral infection and neoplastic transformation trigger endoplasmic reticulum (ER) stress. Thus, a large proportion of the cells that must be recognized by the immune system are stressed cells. Cells respond to ER stress by launching the unfolded protein response (UPR). The UPR...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics