TITLE

Mithramycin encapsulated in polymeric micelles by microfluidic technology as novel therapeutic protocol for beta-thalassemia

AUTHOR(S)
Capretto, Lorenzo; Mazzitelli, Stefania; Brognara, Eleonora; Lampronti, Ilaria; Carugo, Dario; Hill, Martyn; Xunli Zhang; Gambari, Roberto; Nastruzzi, Claudio
PUB. DATE
January 2012
SOURCE
International Journal of Nanomedicine;2012, Vol. 7, p307
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
No abstract available.
ACCESSION #
82508807

 

Related Articles

  • Glycyrrhetinic Acid-Mediated Polymeric Drug Delivery Targeting the Acidic Microenvironment of Hepatocellular Carcinoma. Zhang, Jinming; Zhang, Min; Ji, Juan; Fang, Xiefan; Pan, Xin; Wang, Yitao; Wu, Chuanbin; Chen, Meiwan // Pharmaceutical Research;Oct2015, Vol. 32 Issue 10, p3376 

    Purpose: The major hurdle of current drug carrier against hepatocellular carcinoma (HCC) is the lack of specific and selective drug delivery to HCC. In this study, a novel glycyrrhetinic acid (GA) and poly(L-Histidine) (PHIS) mediated polymeric drug delivery system was developed to target HCC...

  • Polymeric Micelles for Drug Delivery. Croy, S. R.; Kwon, G. S. // Current Pharmaceutical Design;Dec2006, Vol. 12 Issue 36, p4669 

    Polymeric micelles are nanoscopic core/shell structures formed by amphiphilic block copolymers. Both the inherent and modifiable properties of polymeric micelles make them particularly well suited for drug delivery purposes. An emphasis of this review has been placed on both the description and...

  • Tumor Environment Changed by Combretastatin Derivative (Cderiv) Pretreatment That Leads to Effective Tumor Targeting, MRI Studies, and Antitumor Activity of Polymeric Micelle Carrier Systems. Shiraishi, Kouichi; Harada, Yoshiko; Kawano, Kumi; Maitani, Yoshie; Hori, Katsuyoshi; Yanagihara, Kazuyoshi; Takigahira, Misato; Yokoyama, Masayuki // Pharmaceutical Research;Jan2012, Vol. 29 Issue 1, p178 

    Purpose: To evaluate effect of a vascular disrupting agent, a combretastatin derivative (Cderiv), on tumor targeting for polymeric micelle carrier systems, containing either a diagnostic MRI contrast agent or a therapeutic anticancer drug. Methods: Cderiv was pre-administered 72 h before...

  • Micro Solution to Future Developments. Hock, Lindsay // R&D Magazine;Jul/Aug2015, Vol. 57 Issue 4, p16 

    The article discusses the developments in microfluidics technology in life science and materials applications. Topics discussed include use of microfluidics by pharmaceutical industry to address poor aqueous encapsulation rates and size heterogeneity during bioencapsulation, commercialization of...

  • Applications of polymeric micelles with tumor targeted in chemotherapy. Ding, Hui; Wang, Xiaojun; Zhang, Song; Liu, Xinli // Journal of Nanoparticle Research;Nov2012, Vol. 14 Issue 11, p1 

    Polymeric micelles (PMs) have gained more progress as a carrier system with the quick development of biological and nanoparticle techniques. In particular, PMs with smart targeting can deliver anti-cancer drugs directly into tumor cells at a sustained rate. PMs with core-shell structure (with...

  • Disposition of Drugs in Block Copolymer Micelle Delivery Systems. Aliabadi, Hamidreza Montazeri; Shahin, Mostafa; Brocks, Dion R.; Lavasanifar, Afsaneh // Clinical Pharmacokinetics;2008, Vol. 47 Issue 10, p619 

    Since their discovery in the early 1980s, polymeric micelles have been the subject of several studies as delivery systems that can potentially improve the therapeutic performance and modify the toxicity profile of encapsulated drugs by changing their pharmacokinetic characteristics. The efforts...

  • Targeted Polymeric Micelle System for Delivery of Combretastatin A4 to Tumor Vasculature In Vitro. Yiguang Wang; Tingyuan Yang; Xun Wang; Jiancheng Wang; Xuan Zhang; Qiang Zhang // Pharmaceutical Research;Sep2010, Vol. 27 Issue 9, p1861 

    To develop an efficient tumor vasculature-targeted polymeric micelle delivery system for combretastatin A4 (CA4), a novel antivascular agent. CA4-loaded micelles were prepared from poly (ethylene glycol)- b-poly (d, l-lactide) copolymers. RGD peptides that target integrins αvβ3 and...

  • Polymeric micelles as a drug carrier for tumor targeting. Neha, M. Dand; Pranav, B. Patel; Anita, P. Ayre; Vilasrau, J. Kadam // Chronicles of Young Scientists;Jul-Dec2013, Vol. 4 Issue 2, p94 

    Polymeric micelle can be targeted to tumor site by passive and active mechanism. Some inherent properties of polymeric micelle such as size in nanorange, stability in plasma, longevity in vivo, and pathological characteristics of tumor make polymeric micelles to be targeted at the tumor site by...

  • Nanoparticle carriers based on copolymers of poly( l-aspartic acid co- l-lactide)-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine for drug delivery. Han, Siyuan; Wang, Huan; Liang, Xingjie; Hu, Liming; Li, Min; Wu, Yan // Journal of Nanoparticle Research;Sep2011, Vol. 13 Issue 9, p4371 

    A novel poly( l-aspartic) derivative (PAL-DPPE) containing polylactide and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE) segments has been successfully synthesized. The chemical structures of the copolymers were confirmed by Fourier-transform infrared spectroscopy (FTIR), NMR (H NMR, C...

  • Hydrogel-based encapsulation of biological, functional tissue: fundamentals, technologies and applications. Zimmermann, H.; Ehrhart, F.; Zimmermann, D.; M#x00FC;ller, K.; Katsen-Globa, A.; Behringer, M.; Feilen, P. J.; Gessner, P.; Zimmermann, G.; Shirley, S. G.; Weber, M. M.; Metze, J.; Zimmermann, U. // Applied Physics A: Materials Science & Processing;Dec2007, Vol. 89 Issue 4, p909 

    Replacing dysfunctional endocrine cells or tissues (e.g. islets, parathyroid tissue) by functional, foreign material without using immunosuppressives could soon become reality. Immunological reactions are avoided by encapsulating cells/tissues in hydrogel (e.g. alginate) microcapsules,...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics