TITLE

Copper at the Front Line of the Host-Pathogen Battle

AUTHOR(S)
Festa, Richard A.; Thiele, Dennis J.
PUB. DATE
September 2012
SOURCE
PLoS Pathogens;Sep2012, Vol. 8 Issue 9, Special section p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article discusses the role of copper in microbial pathogenesis. The transition metal functions as a cofactor for enzymes due to its ability to redox cycle between reduced and oxidized forms, but it can also lead to oxidative stress and disrupt iron-sulfur clusters and displace other metals from their cognate enzymes, leading to inactivation. Information on how fungi use and resist copper is provided.
ACCESSION #
82499904

 

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