Copper at the Front Line of the Host-Pathogen Battle

Festa, Richard A.; Thiele, Dennis J.
September 2012
PLoS Pathogens;Sep2012, Vol. 8 Issue 9, Special section p1
Academic Journal
The article discusses the role of copper in microbial pathogenesis. The transition metal functions as a cofactor for enzymes due to its ability to redox cycle between reduced and oxidized forms, but it can also lead to oxidative stress and disrupt iron-sulfur clusters and displace other metals from their cognate enzymes, leading to inactivation. Information on how fungi use and resist copper is provided.


Related Articles

  • Exogenous manganous ion at millimolar levels rescues all known dioxygen-sensitive phenotypes of yeast lacking CuZnSOD. Sanchez, Raylene; Srinivasan, Chandra; Munroe, William; Wallace, Matthew; Martins, Jacob; Kao, Tina; Le, Kate; Gralla, Edith; Valentine, Joan // Journal of Biological Inorganic Chemistry;Dec2005, Vol. 10 Issue 8, p913 

    Yeasts lacking copper-zinc superoxide dismutase ( sod1Δ) exhibit a broad range of phenotypes, many of which can be rescued by growth in the presence of high levels of ionic manganese. We undertook a comprehensive survey of the effects of manganese on wild-type and sod1Δ yeasts and found...

  • Effects of Cadmium on Wheat Growth and Some Physiological Factors. Amirjani, Mohammad Reza // International Journal of Forest, Soil & Erosion;Feb2012, p50 

    The aim of this study is to examine the effects of Cd on the growth, oxidative stress, and antioxidative enzymes as well as on photosynthetic performance of early wheat seedlings. The possible mechanisms of wheat seedlings, response to Cd stress involving free radical metabolism and antioxidant...

  • Involvement of thio-, peroxi-, and glutaredoxins in cellular redox-dependent processes. Kalinina, E.; Chernov, N.; Saprin, A. // Biochemistry (00062979);Dec2008, Vol. 73 Issue 13, p1493 

    Among the key antioxidant enzymes, thioredoxin and glutaredoxin systems play an important role in cell defense against oxidative stress and maintenance of redox homeostasis owing to the regulation of thiol—disulfide exchange. The thioredoxin isoforms Trx1 (cytoplasmic form) and Trx2...

  • The dilemma of hyperoxia following positive pressure mechanical ventilation: role of iron and the benefit of iron chelation with deferasirox. MOUSAVI, S.; ABDOLLAHI, M.; AHMADI, A.; NAJAFI, A.; PAZOUKI, M.; HADJIBABAIE, M.; ZIAEE, S.; HAMISHEHKAR, H.; KEBRIAEEZADEH, A.; MOJTAHEDZADEH, M. // European Review for Medical & Pharmacological Sciences;2011, Vol. 15 Issue 10, p1141 

    Background and Objective: Increased oxidative stress in patients under treatment with high concentrations of oxygen (hyperoxia) is considered to be one of the major mechanisms of lung injury, which is thought among different mediators, transition metal ion, iron, by generation of very reactive...

  • Toxicity of Transition Metal Oxide Nanoparticles: Recent Insights from in vitro Studies. Yue-Wern Huang; Chi-heng Wu; Aronstam, Robert S. // Materials (1996-1944);Oct2010, Vol. 3 Issue 10, p4842 

    Nanotechnology has evolved to play a prominent role in our economy. Increased use of nanomaterials poses potential human health risk. It is therefore critical to understand the nature and origin of the toxicity imposed by nanomaterials (nanotoxicity). In this article we review the toxicity of...

  • Fungal Decomposition of Natural Aromatic Structures and Xenobiotics: A Review. Rabinovich, M. L.; Bolobova, A. V.; Vasil'chenko, L. G. // Applied Biochemistry & Microbiology;Jan/Feb2004, Vol. 40 Issue 1, p1 

    The review deals with transformation of natural and synthetic aromatic compounds by fungi (causative agents of white rot, brown rot, and soft rot, as well as soil filamentous fungi). Major enzyme types involved in the transformation of lignin and aromatic xenobiotics are discussed, with emphasis...

  • Activation of the hexose monophosphate shunt in rat type II pneumocytes as an early marker of oxidative stress caused by cobalt particles. Hoet, Peter M. H.; Roesems, Goedele; Demedts, Maurits G.; Nemery, Benoit // Archives of Toxicology;Feb2002, Vol. 76 Issue 1, p1 

    Cobalt metal (mCo) and hard metal, a mixture of cobalt and tungsten carbide (CoWC), are cytotoxic for alveolar macrophages and alveolar type II cells (AT-II). Although the exact mechanisms of toxicity are not entirely elucidated, evidence exists for an oxidant-mediated toxicity. In this study,...

  • Inclusion of Additional Coordination Sphere into Cluster-Model Redox Potential Calculations. Uudsemaa, Merle; Tamm, Toomas // AIP Conference Proceedings;12/26/2007, Vol. 963 Issue 2, p495 

    Combination of cluster model for the inner solvation spheres with dielectric continuum solvation model for the bulk solvent has previously yielded good accuracy for prediction of redox potentials of transition metal cations. The influence of adding a third solvation sphere to the cluster on the...

  • Gene expression profiling of liver cells after copper overload in vivo and in vitro reveals new copper-regulated genes. Muller, Patricia; Bakel, Harm; Sluis, Bart; Holstege, Frank; Wijmenga, Cisca; Klomp, Leo // Journal of Biological Inorganic Chemistry;May2007, Vol. 12 Issue 4, p495 

    Copper toxicity in the liver is mediated by free-radical generation, resulting in oxidative stress. To prevent toxic accumulation of copper, liver cells adapt to high copper levels. Here, we used microarray analysis to compare the adaptive responses on global gene expression in liver cells...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics