A new E-ring γ-lactone pentacyclic triterpene from Lysimachia clethroides and its cytotoxic activities

Xu, Qiong-ming; Liu, Yan-li; Feng, Yu-lin; Tang, Li-hua; Yang, Shi-lin
September 2012
Chemistry of Natural Compounds;Sep2012, Vol. 48 Issue 4, p597
Academic Journal
A new E-ring γ-lactone pentacyclic triterpene, 3β-myristoxyurs-12-en-19,28-olide, has been isolated from the chloroform extract of Lysimachia clethroides Duby, together with four known pentacyclic triterpenoid acids. The structures of the compounds were elucidated by comprehensive spectroscopic analyses. All of the compounds showed various degrees of cytotoxic activities in MTT assay.


Related Articles

  • Synthesis and Cytotoxic Activity of Lupane Triterpenoids Containing 1,3,4-Oxadiazoles. Antimonova, A.; Petrenko, N.; Shakirov, M.; Pokrovskii, M.; Pokrovskii, A.; Shul'ts, E. // Chemistry of Natural Compounds;Dec2014, Vol. 50 Issue 6, p1016 

    New derivatives of betulonic and betulinic acids with 1,3,4-oxadiazole substituents in the C-17 position were prepared. The cytotoxic activity of the betulonic acid derivatives was studied using MT-4, CEM-13, and U-937 human tumor cell models.

  • Synthesis and Biological Evaluation of 2,5-Bis(alkylamino)-1,4-benzoquinones. Almeida Barbosa, Luiz Cláudio; Alves Pereira, Ulisses; Alvares Maltha, Célia Regina; Ricardo Teixeira, Róbson; Moreira Valente, Vânia Maria; Oliveira Ferreira, José Roberto; Costa-Lotufo, Letícia Veras; Odorico Moraes, Manoel; Pessoa, Cláudia // Molecules;Aug2010, Vol. 15 Issue 8, p5629 

    A series of twelve 2,5-bis(alkylamino)-1,4-benzoquinones were prepared in yields ranging from 9-58% via the reaction between p-benzoquinone and various amines. The structures of the synthesized compounds were confirmed by IR, ¹H- and 13C-NMR and MS analyses. The phytotoxicity of the...

  • Cytotoxic Activity of β-Caryophyllene Oxide Isolated from Jeju Guava (Psidium cattleianum Sabine) Leaf. Neung Jae Jun; Mosaddik, Ashik; Jeong Yong Moon; Ki-Chang Jang; Dong-Sun Lee; Kwang Seok Ahn; Cho, Somi K. // Records of Natural Products;2011, Vol. 5 Issue 3, p242 

    β-caryophyllene oxide was isolated from the leaf of the Jeju guava (Psidium cattleianum Sabine) for the first time in this study. The chemical structure was confirmed with the help of various spectroscopic analyses, including NMR data, by comparison to that of the published data. An MTT assay...

  • Structure elucidation, protein profile and the antitumor effect of the biological active substance extracted from sea cucumber Holothuria polii. Omran, Nahla EE; Khedr, Abdalla M // Toxicology & Industrial Health;Jan2015, Vol. 31 Issue 1, p1 

    Holothuria polii (Delle Chiaje, 1823) (Holothuriidae) is a sea cucumber inhabiting Mediterranean Sea coast of Egypt. The bioactive compound of its tegument has antifungal, antibacterial and antiparasitic effects. The present study aims to elucidate the structure of the bioactive material of H....

  • Three New Multiflorane-Type Triterpenes from Pumpkin (Cucurbita maxima) Seeds. Takashi Kikuchi; Mika Takebayashi; Mayumi Shinto; Takeshi Yamada; Reiko Tanaka // Molecules;May2013, Vol. 18 Issue 5, p5568 

    Three new multiflorane-type triterpenes; 7α-methoxymultiflor-8-ene-3α,29-diol 3-acetate-29-benzoate (1), 7-oxomultiflor-8-ene-3α29-diol 3-acetate-29-benzoate (2), and multiflora-7,9(11)-diene-3α,29-diol 3-p-hydroxybenzoate-29-benzoate (3), were isolated from seeds of Cucurbita...

  • Three New Ring-A Modified Ursane Triterpenes from Davidia involucrata. Qing-Wei Tan; Ming-An Ouyang; Bo Gao // Molecules;Apr2014, Vol. 19 Issue 4, p4897 

    Three new ursane triterpenes, 3α,19α-dihydroxy-2-nor-urs-12-en-23,28-dioic acid-23-methyl ester (1), 19α3-dihydroxy-3-oxo-2-nor-urs-12-en-28-oic acid (2), and 2,3-seco-3-methoxy-3,19α,23-trihydroxy-urs-12-en-2-al-28-oic acid (3), were isolated from the MeOH extract of...

  • Structure of a molecular hole-punch. Sansom, Mark S.P. // Nature;1/30/1997, Vol. 385 Issue 6615, p390 

    Provides background and analysis for a report of the crystal structure of an intact colicin molecule, namely colicin Ia. The three domains responsible for the three stages of attack by bacterial toxins on the membrane of a target cell; The significance of colicin Ia's long alpha-helices; The...

  • Crystal structure of colicin Ia. Wiener, Michael; Freymann, Douglas // Nature;1/30/1997, Vol. 385 Issue 6615, p461 

    Reports the crystal structure of colicin Ia. The presence of three distinct functional domains; The existence of two very long alpha-helices; The use of the helices for reaching across the plasma membrane of the target cell.

  • Cytotoxic Oligostilbenoids from Vatica odorata. Jalifah Latip; Wan Zuraida Wan Mohd Zain; Norizan Ahmat; Bohari M. Yamin; Nik Idris Nik Yusof; Yana M. Syah; Sjamsul A. Achmad // Australian Journal of Basic & Applied Sciences;2011, Vol. 5 Issue 6, p113 

    Five oligostilbenoids, (-)-trans-resveratrol-13-O-b-D-glucopyranoside 1, (-)-e-viniferin 2, (-)- laevifonol 3 and (-)-hopeaphenol 4, (-)-vaticanol B 5, together with a gallic acid derivative, (-)- bergenin 6, were isolated from the acetone and methanol extracts of the tree bark of Vatica...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics