TITLE

FORMULATION AND IN-VITRO EVALUATION OF LITHIUM CARBONATE EXTENDED RELEASE TABLET TO STUDY THE EFFECT OF VARIOUS CONCENTRATION OF HYDROPHILIC AND HYDROPHOBIC MATRIX IN COMPARISON WITH INNOVATOR'S PRODUCT

AUTHOR(S)
Srinivasan, Gopinath; Chidambaram, Moorthi; Krishnan, Kiran; Subburayalu, Raja; Krishnasamy, Kathiresan
PUB. DATE
October 2012
SOURCE
International Journal of Pharmacy & Pharmaceutical Sciences;Oct2012 Supplement, Vol. 4, p632
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Conventional lithium carbonate tablet produce rapid and relatively high peak serum lithium level which results in adverse effects. However, this limitation can be effectively overcome by extended release formulation. Innovator's lithium carbonate 300 mg extended release tablets produce an effective serum lithium concentration ranging between 1.0-1.5 mEq/L. The primary aim of the present study was to formulate an extended release tablet formulation of lithium carbonate using hydrophilic and hydrophobic matrix and to study the effect of various concentration of hydrophilic and hydrophobic matrix on in-vitro drug release of lithium carbonate from its extended release formulation in comparison with innovator's product. Eight formulations (F1-F8) were prepared by wet granulation method. Out of eight formulations, only formulation F5complies with USP limits at all time points and comparable with innovator's product. Hence the present study concludes that the in-vitro drug release profile of lithium carbonate extended release tablets prepared using Hydroxypropylmethyl cellulose K 4M was comparable with innovator's product at 5% w/w concentration.
ACCESSION #
82072798

 

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