TITLE

Characteristics of cytochrome P-450 and mixed function oxidase enzymes following treatment with PBBs

AUTHOR(S)
Dent, J. G.
PUB. DATE
April 1978
SOURCE
Environmental Health Perspectives;Apr1978, Vol. 23, p301
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
No abstract available.
ACCESSION #
8095314

 

Related Articles

  • Pure non-dioxin-like PCB congeners suppress induction of AhR-dependent endpoints in rat liver cells. Brenerová, Petra; Hamers, Timo; Kamstra, Jorke; Vondráček, Jan; Strapáčová, Simona; Andersson, Patrik; Machala, Miroslav // Environmental Science & Pollution Research;Feb2016, Vol. 23 Issue 3, p2099 

    The relative potencies of non- ortho-substituted coplanar polychlorinated biphenyl (PCB) congeners to activate the aryl hydrocarbon receptor (AhR) and to cause the AhR-dependent toxic events are essential for their risk assessment. Since some studies suggested that abundant non-dioxin-like PCB...

  • Hepatic Transcript Levels for Genes Coding for Enzymes Associated with Xenobiotic Metabolism are Altered with Age. Mori, Kazuhiko; Blackshear, Pamele E.; Lobenhofer, Edward K.; Parker, Joes S.; Ozrech, Denise P.; Roycroft, Joseph H.; Walker, Kimwa L.; Johnson, Kennita A.; Marsh, Tiwanda A.; Irwin, Richard D.; Boorman, Gary A. // Toxicologic Pathology;2007, Vol. 35 Issue 2, p242 

    Metabolism studies are crucial for data interpretation from rodent toxicity and carcinogenicity studies. Metabolism studies are usually conducted in 6 to 8 week old rodents. Long-term studies often continue beyond 100 weeks of age. The potential for age-related changes in transcript levels of...

  • Acute, Short-Term, and Subchronic Oral Toxicity of 1,1,1-Trichloroethane in Rats. Bruckner, James V.; Kyle, Glenna M.; Luthra, Raja; Acosta, Daniel; Mehta, Sanjay M.; Sethuraman, Sankar; Muralidhara, Srinivasa // Toxicological Sciences;Apr2001, Vol. 60 Issue 2, p363 

    1,1,1-Trichloroethane (TRI) is a widely used solvent that has become a frequent contaminant of drinking water supplies in the U.S. There is very little information available on the potential for oral TRI to damage the liver or to alter its P450 metabolic capacity. Thus, a major objective of this...

  • Strain differences in hepatic cytochrome P450 1A 3A expression between Sprague-Dawley and Wistar rats. Kishida, Tomoyuki; Muto, Shin-ichi; Hayashi, Morimichi; Tsutsui, Masaru; Tanaka, Satoru; Murakami, Makoto; Kuroda, Junji // Journal of Toxicological Sciences;Oct2008, Vol. 33 Issue 4, p447 

    Expression of hepatic cytochrome P450 (CYP) isoforms was compared in Sprague-Dawley (SD) and Wistar (WI) rats, which are commonly used strains in preclinical studies. Basal CYP1A1, CYP1A2, and CYP3A2 mRNA levels were higher in WI rats than in SD rats (by 8-, 3- and 2-fold, respectively)....

  • The effect of banol and paraoxon on the nadph-cytochrome c reductaseactivity and cytochrome P-450 content in rats Neskovic, N. K.; Vitorovic, S. Lj. // Bulletin of Environmental Contamination & Toxicology;Oct1977, Vol. 18 Issue 4, p472 

    No abstract available.

  • © MICROSOMAL PROTEIN SYNTHESIS AND INDUCTION OF CYTOCHROME P-450 IN CIRRHOTIC RAT LIVER. Farrel, Geoffrey C.; Zaluzny, Louise // Australian Journal of Experimental Biology & Medical Science;Jun1984, Vol. 62 Issue 3, p291 

    Studies microsomal protein synthesis and induction of cytochrome P-450 in cirrhotic rat liver. Production of cirrhosis in rats; Response to microsomal enzyme-inducing agents; Evaluation of the entire process of enzyme induction.

  • Enzymatic detoxication of DDT to DDD by rat liver: Effects of some inducers and inhibitors of cytochrome P-450 enzyme system. Zaidi, S.; Banerjee, B. // Bulletin of Environmental Contamination & Toxicology;Mar1987, Vol. 38 Issue 3, p449 

    The article discusses a study on the enzymatic detoxification of DDT to DDD by rat liver after administration of a single threshold dose of DDT. The study used DDT and DDD purchased from Aldrich Chemical Co. and other chemicals including phenobarbital (Pb), and employed National Institute of...

  • Celecoxib enhances the detoxification of diethylnitrosamine in rat liver cancer. Salcido-Neyoy, Martha Estela; Sierra-Santoyo, Adolfo; Beltrán-Ramírez, Olga; Macías-Pérez, José Roberto; Villa-Treviño, Saúl; Jian Wu; Mine, Tetsuya // World Journal of Gastroenterology;5/21/2009, Vol. 15 Issue 19, p2345 

    AIM: To study the effect of celecoxib (CXB) on diethylnitrosamine activation through the regulation of cytochrome P450 in a hepatocarcinogenesis model. METHODS: Six-week-old male Sprague-Dawley rats were randomly divided into five groups, a non-treated group (NT), a diethylnitrosamine-treated...

  • Cytochrome P450-Mediated Metabolism and Nephrotoxicity of N-(3,5-Dichlorophenyl)succinimide in Fischer 344 Rats. Nyarko, Alexander K.; Kellner-Weibel, Ginny L.; Harvison, Peter J. // Fundamental & Applied Toxicology;1997, Vol. 37 Issue 2, p117 

    The agricultural fungicide N-(3,5-dichlorophenyl)succinimide (NDPS) is nephrotoxic in rats. Previous studies have suggested that oxidative hepatic biotransformation is required for the induction of kidney damage. The experiments described in this paper were designed to further investigate the...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics