TITLE

Comparative Study of the Cytotoxicity and Genotoxicity of Alpha- and Beta-Asarone

AUTHOR(S)
Unger, Pascal; Melzig, Matthias F.
PUB. DATE
July 2012
SOURCE
Scientia Pharmaceutica;2012, Vol. 80 Issue 3, p663
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The cytotoxicity of alpha- and beta-asarone was investigated with the BrdU assay in HepG2-cells. Alpha-asarone was found to be more toxic than beta-asarone after 24 hours of treatment. Investigation of the genotoxicity using the micronucleus assay in the HepG2-cell system showed that only after metabolic activation by a liver microsomal preparation, beta-asarone was able to induce micronuclei at concentrations higher than 50 μg/mL.
ACCESSION #
80915087

 

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