TITLE

Clinicopathological Analysis of Patients with Nonmuscle-Invasive Bladder Cancer Who Underwent Radical Cystectomy

AUTHOR(S)
Nishiyama, Naotaka; Kitamura, Hiroshi; Mutoh, Masatoshi; Yanase, Masahiro; Iwaki, Hiroyuki; Hasegawa, Tadashi; Tsukamoto, Taiji
PUB. DATE
July 2012
SOURCE
Surgical Science;Jul2012, Vol. 3 Issue 7, p347
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objectives: Surgical specimens obtained at the time of the last transurethral resection of bladder tumor (TURBT) for patients with nonmuscle-invasive bladder cancer (NMIBC) who underwent radical cystectomy were retrospectively evaluated in order to investigate the relationship between pathological variation and upstaging of NMIBC. Methods and Materials: Twenty patients (19 men, 1 woman; aged 69.4 ± 12.1 (mean ± SD) years) diagnosed with NMIBC underwent radical cystectomy during follow-up. Results: Five of the 20 patients (25%) had pathological upstaging in the radical cystectomy specimens. There was a statistical association between pathological upstaging and cancer death (p = 0.002). There were three patterns of pathological variation in the upstaged specimens: 1) In patients with BCG-resistant NMIBC, urothelial carcinoma invaded through the lamina propria; 2) Urothelial carcinoma showed diffuse invasion beyond the deep lamina propria, and the cancer cells had infiltrated as single cells and formed nodules; 3) TURBT specimens showed a micropapillary variant. Conclusions: Since these pathological variations correlated with pathological upstaging, they may provide an indication for cystectomy in NMIBC patients.
ACCESSION #
80826660

 

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