TITLE

Evaluation of Diuretic Activity of Aqueous and Methanol Extracts of Sesbania grandiflora Linn in Rats

AUTHOR(S)
Eswaraiah, M.Chinna; Elumalai, A.; Nikhitha, M.; Areefa, S.; Mamatha, A.; Usha; Srikanth, N.
PUB. DATE
April 2012
SOURCE
International Journal of PharmTech Research;Apr-Jun2012, Vol. 4 Issue 2, p835
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In this present study, the diuretic activity was screened for methanol and aqueous extracts of Sesbania grandiflora Linn flowers. The animals were grouped into six of six groups. Test extracts were administered to experimental rats orally at doses of 150 and 300 mg/kg p.o suspended in carboxy methyl cellulose. The diuretic effect of the extracts was evaluated by measuring urine volume, sodium and potassium content, conductivity and pH. Urine volume was significantly increased by the two doses of aqueous and methanol extracts in comparison to control group. While the excretion of sodium was also increased by both extracts, potassium excretion was only increased by the aqueous extract at a dose of 300 mg/kg. There was no significant change in the conductivity and pH of urine after administration of the Sesbania grandiflora extracts. The diuretic effect of the extracts was comparable to that of the reference standard Furosemide (20mg/kg, p.o). The present study provides a quantitative basis for explaining the folkloric use of Sesbania grandiflora as a diuretic agent.
ACCESSION #
80731686

 

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