TITLE

Synthetic biology: Programming transcription

PUB. DATE
October 2012
SOURCE
Nature Methods;Oct2012, Vol. 9 Issue 10, p946
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article offers information on the application of transcription factors (TFs) in regulated gene expression network within the cells.
ACCESSION #
80731377

 

Related Articles

  • Transcription Factors As Targets for DNA-Interacting Drugs. M. Gniazdowski; W.A. Denny; S.M. Nelson; M. Czyz // Current Medicinal Chemistry;Jun2003, Vol. 10 Issue 11, p909 

    Gene expression, both tissue specific or inducible, is controlled at the level of transcription by various transcription factors interacting with specific sequences of DNA. Anticancer drugs and other potential therapeutic agents alter interactions of regulatory proteins with DNA by a variety of...

  • Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors. Ostendorff, Heather P.; Peirano, Reto I.; Peters, Marvin A.; Schl├╝ter, Anne; Bossenz, Michael; Scheffner, Martin; Bach, Ingolf // Nature;3/7/2002, Vol. 416 Issue 6876, p99 

    Examines the ubiquitination-dependent cofactor exchange on LIM homeodomain (HD) transcription factors for the regulation of gene expression. Inhibition of the function of LIM-HD transcription factors by co-repressor ring finger LIM (RLIM); Association of RLIM with LIM-HD; Ability of RLIM to...

  • Regulation of UDP Glucuronosyltransferase Genes. P.I. Mackenzie; P.A. Gregory; D.A. Gardner-Stephen; R.H. Lewinsky; B.R. Jorgensen; T. Nishiyama; W. Xie; A. Radominska-Pandya // Current Drug Metabolism;Jun2003, Vol. 4 Issue 3, p249 

    The UDP glucuronosyltransferase (UGT) content of cells and tissues is a major determinant of our response to those chemicals that are primarily eliminated by conjugation with glucuronic acid. There are marked interindividual differences in the content of UGTs in the liver and other organs. The...

  • Regulation of endogenous gene expression with a small-molecule dimerizer. Pollock, Roy; Giel, Maryann; Linher, Katja; Clackson, Tim // Nature Biotechnology;Jul2002, Vol. 20 Issue 7, p729 

    Artificial transcription factors containing designer zinc-finger DNA-binding domains (DBDs) have been used to activate or repress expression of a growing number of endogenous genes. We have combined targeted zinc-finger DBD technology with a dimerizer-regulated gene expression system to permit...

  • Peroxisome proliferator-activated receptors: A family of lipid-activated transcription factors. Clarke, Steven C.; Thuillier, Philippe // American Journal of Clinical Nutrition;Oct99, Vol. 70 Issue 4, p566 

    Describes the characteristics, regulation and gene targets for peroxisome proliferator-activated receptors (PPAR) and their effects on gene expression to physiologic outcomes that affect lipid and glucose metabolism, thermogenesis, atherosclerosis and cell differentiation. PPAR family of...

  • Nrf2 Regulates Thromboxane Synthase Gene Expression in Human Lung Cells. Yaekashiwa, Masahiro; Lee-Ho Wang // DNA & Cell Biology;Aug2003, Vol. 22 Issue 8, p479 

    Thromboxane A[sub 2] synthase (TXAS) converts prostaglandin H[sub 2] to thromboxane A[sub 2], a potent inducer of vaso-constriction and platelet aggregation. TXAS expression level is cell type preferential; high in hematopoietic cells and low in nonhematopoietic cells. We previously showed that...

  • Regulation of gene expression and cocaine reward by CREB and ?FosB. McClung, Colleen A.; Nestler, Eric J. // Nature Neuroscience;Nov2003, Vol. 6 Issue 11, p1208 

    ?FosB (a truncated form of FosB) and CREB (cAMP response element binding protein) are transcription factors induced in the brain's reward pathways after chronic exposure to drugs of abuse. However, their mechanisms of action and the genes they regulate remain unclear. Using microarray analysis...

  • One-Eyed Pinhead and Spadetail are essential for heart and somite formation. Griffin, Kevin J.; Kimelman, David // Nature Cell Biology;Oct2002, Vol. 4 Issue 10, p821 

    Mutant analysis in the zebrafish Danio rerio has demonstrated distinct developmental roles for the T-box transcription factor Spadetail (Spt) and the Nodal-receptor cofactor One-Eyed Pinhead (Oep) in the formation of mesoderm and endoderm. Here, we show that spt and oep genetically interact and...

  • Putting the Finger on Gene Expression. Mackay, Joel // Australasian Science;Apr2003, Vol. 24 Issue 3, p38 

    Focuses on the potential of protein segments that use zinc ions to stabilize their structure to be suitable scaffolds for drugs targeted at specific diseases. Details and mechanisms of gene expression; Ways in which the N-finger can make specific contact with zinc fingers in other transcription...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics