The Potency of Rhizophora mucronata Leaf Extract as Antidiarrhea

Puspitasar, Yunita E.; Hartiati, Aniek M.; Suprayitno, Eddy
February 2012
Journal of Applied Sciences Research;Feb2012, Vol. 8 Issue 2, p1180
Academic Journal
Rhizophora mucronata is commonly known as mangrove growth in the tropical and subtropical region coastlines. It is a natural source of tannins and flavonoid. R. mucronata leaf has been used in the folk medicine for treating diarrhea or gastric motility disorder. The aim of the study was to evaluate the effect of R. mucronata leaf extract on ileum motility in rats. This study was intended to identify active compound from R. mucronata leaf by phytochemical screening. The characterization of tannins from R. mucronata leaf used reversed phase high performance liquid chromatography (HPLC). Crude extract of leaf was evaluated on isolated rat ileum. Anti-motility effect of different concentrations (0.15-0.75%) of R. mucronata leaf extract was assessed on methacholine precontracted isolated ileum. An isolated ileum of rat was immersed in an organ bath which contained aerated Tyrode solution. The tissue was stimulated with methacholine (10-5M) and its responses were recorded by Power Lab. Various concentrations of the extract (0.15%, 0.30%, 0.45%, 0.60% and, 0.75%) were applied to the tissue then the tissue's responses were recorded. The result showed that the extract relaxed or reduced the contractions of isolated rats ileum. Based on the High Performance Liquid Chromatography (HPLC) analysis, R. mucronata leaf extract contained catechin 47.428 ppm and epigallocatechin 3.150 ppm. The result indicated that the components of R. mucronata leaf had a potential use in the treatment of gastrointestinal motility such as diarrhea. The most effective concentration of R. mucronata leaf extract in decreasing motility of the ileum was 0.50%, reduced 51.52 (%) ± 10.85 motility of the ileum by direct action on smooth muscle cells.


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