TITLE

Haematological values in homozygous sickle cell disease in steady state and haemoglobin phenotypes AA controls in Lagos, Nigeria

AUTHOR(S)
Akinbami, Akinsegun; Dosunmu, Adedoyin; Adediran, Adewumi; Oshinaike, Olajumoke; Adebola, Phillip; Arogundade, Olanrewaju
PUB. DATE
January 2012
SOURCE
BMC Research Notes;2012, Vol. 5 Issue 1, p396
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Sickle cell disease is a genetic abnormality involving the haemoglobin. Although, it is primarily a red cell disorders, the white blood cells and platelets are also affected by the mutation. The consequent haemoglobin S causes polymerization of haemoglobin resulting in haemolysis and anaemia. This study aims to provide baseline haematological values in sickle cell disease patients in steady state and compare the deviation from haemoglobin phenotype AA control values. Methods: A case-control study was conducted amongst homozygous sickle cell patients attending the sickle cell clinics of Lagos State University Teaching Hospital Ikeja and haemoglobin phenotype AA controls. About 4.5mls of blood sample was collected from each participant for full blood count analysis. All blood samples were screened for HIV and haemoglobin phenotypes confirmed using cellulose acetate haemoglobin electrophoresis at pH 8.6. Results: A total of 103 cases and 98 controls were enrolled. The overall mean haemoglobin concentration for cases was 7.93 ± 1.47 g/dl, packed cell volume 24.44 ± 4.68%, mean cell volume 81.52 ± 7.89 fl, and mean cell haemoglobin 26.50 ± 3.20 pg. While for controls, mean haemoglobin concentration was 13.83 ± 1.32 g/dl, packed cell volume 43.07 ± 3.95%, mean cell volume 86.90 ± 4.69 fl, and mean cell haemoglobin 28.50 ± 1.34 pg. The overall mean white blood cell counts for the cases was 10.27 ± 3.94 *103/μl and platelet counts of 412.71 ± 145.09*103/μl. While white blood cell count for the controls was 5.67 ± 1.59*103/μl and platelet counts of 222.82 ± 57.62*103/μl. Conclusion: Homozygous sickle cell disease patients have lower values of red cell parameters, but higher values of white cell and platelets counts compared to haemoglobin phenotype AA controls.
ACCESSION #
79961995

 

Related Articles

  • Steady-state platelet count and complications of sickle cell disease.  // Hematology Journal;2002, Vol. 3 Issue 4, p214 

    Studies the correlation between the number of complications of sickle cell disease (SCD) and steady-state platelet count. Effect of the number of erythrocytes containing hemoglobin in people with SCD on the prevention and treatment of major complications; Confirmation of the platelet count and...

  • An up-date on the prevalence of sickle cell trait in Eastern and Western Uganda. Okwi, Andrew L.; Byarugaba, Wilson; Ndugwa, Christopher M.; Parkes, Arthur; Ocaido, Michael; Tumwine, James K. // BMC Blood Disorders;2010, Vol. 10, p5 

    Background: The first survey on sickle cell disease (SCD) done in Uganda in 1949, reported the district of Bundibugyo in Western Uganda to have the highest sickle cell trait (SCT) prevalence (45%). This is believed to be the highest in the whole world. According to the same survey, the...

  • Platelet distribution width (PDW) is increased in vaso-occlusive crisis in sickle cell disease. Amin, Manik A.; Amin, Amit P.; Kulkarni, Hemant R. // Annals of Hematology;Jun2004, Vol. 83 Issue 6, p331 

    Considering the multigenic and multifactorial nature of the disease, we argue that a generalized bone marrow hyperplasia—and not merely erythroid hyperplasia—will occur in sickle cell disease. Consequently, we expect the hematological parameters to depict erythroid, myeloid as well...

  • Homozygous Hemoglobin D Disease: A Case Report. Desai, Devenkumar Vasantray; Dhanani, Hiren; Shah, Mehul; Dayal, Nitin; Kapoor, Amit; Yeluri, Sashidhar V. // Internet Journal of Pathology;2004, Vol. 3 Issue 1, p13 

    Homozygous Hb D disease is a rare disease and usually presents with mild hemolytic anemia and mild to moderate splenomegaly. Heterozygous form of Hb D is clinically silent, but coinheritance of Hb D with Hb S or thalassemia produces clinically significant conditions like sickle cell anemia and...

  • Opportunities to Improve Outcomes in Sickle Cell Disease. Mehta, Satyen R.; Afenyi-Annan, Araba; Byrns, Patricia J.; Lottenberg, Richard // American Family Physician;7/15/2006, Vol. 74 Issue 2, p303 

    Sickle cell disease represents a spectrum of inherited hemoglobin disorders. The pathophysiology involves abnormalities not just in red blood cells but also vascular endothelium, white blood cell function, coagulation, and inflammatory response. Known sequelae of sickle cell disease include...

  • Acute splenic sequestration crisis in adults with hemoglobin S-C disease: a report of nine cases. Koduri, Prasad; Nathan, Sunita // Annals of Hematology;Apr2006, Vol. 85 Issue 4, p239 

    Acute splenic sequestration crisis (ASSC) is a potentially life-threatening complication and one of the leading causes of death in children with sickle cell disease. It is rarely reported in adults with hemoglobin S-C disease and its natural history in these patients has not been well studied....

  • Hematology (Part 2): Bad Blood. Pelino, Carlo J.; Pizzimenti, Joseph J. // Review of Optometry;11/15/2011, Vol. 148 Issue 11, p80 

    The article discusses common hematologic disorders, particularly sickle cell disease. It states that sickle cell disease is an inherited disorder that affects red blood cells (RBCs). It describes the clinical profile of sickle cell disease, determining its complications and painful crises. It...

  • Chapter 8: The Normochromic Anemias Caused by Hemoglobinopathies. Ciesla, Betty // Hematology in Practice;2007, p113 

    Chapter 8 of the book "Hematology in Practice" is presented. It discusses the characteristics of the hemoglobinopathies. The pathophysiology and the amino acid substitution in sickle cell disorders are described, as well as the inheritance patterns of the disorders. It also differentiates the...

  • sick·le cell anemia.  // American Heritage Student Science Dictionary;2009, p309 

    A definition of the term "sickle cell anemia" is presented. It refers to a hereditary disease characterized by red blood cells that are sickle-shaped instead of round because of an abnormality in the hemoglobin, the protein that carries oxygen in the blood. INSET: sickle cell anemia.

Share

Read the Article

Courtesy of

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics