TITLE

Sex Differences in the Association between Serum Levels of Testosterone and Frailty in an Elderly Population: The Toledo Study for Healthy Aging

AUTHOR(S)
Carcaillon, Laure; Blanco, Carmen; Alonso-Bouzòn, Cristina; Alfaro-Acha, Ana; Garcia-García, Francisco-Jose; Rodriguez-Mañas, Leocadio
PUB. DATE
March 2012
SOURCE
PLoS ONE;Mar2012, Vol. 7 Issue 3, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Age-associated decline in testosterone levels represent one of the potential mechanisms involved in the development of frailty. Although this association has been widely reported in older men, very few data are available in women. We studied the association between testosterone and frailty in women and assessed sex differences in this relationship. Methods: We used cross-sectional data from the Toledo Study for Healthy Aging, a population-based cohort study of Spanish elderly. Frailty was defined according to Fried's approach. Multivariate odds-ratios (OR) and 95% confidence intervals (CI) associated with total (TT) and free testosterone (FT) levels were estimated using polytomous logistic regression. Results: In women, there was a U-shaped relationship between FT levels and frailty (p for FT2 = 0.03). In addition, very low levels of FT were observed in women with ≥4 frailty criteria (age-adjusted geometric means = 0.13 versus 0.37 in subjects with <4 components, p = 0.010). The association of FT with frailty appeared confined to obese women (p-value for interaction = 0.05).In men, the risk of frailty levels linearly decreased with testosterone (adjusted OR for frailty = 2.9 (95%CI, 1.6-5.1) and 1.6 (95%CI, 1.0-2.5), for 1 SD decrease in TT and FT, respectively). TT and FT showed association with most of frailty criteria. No interaction was found with BMI. Conclusion: There is a relationship between circulating levels of FT and frailty in older women. This relation seems to be modulated by BMI. The relevance and the nature of the association of FT levels and frailty are sex-specific, suggesting that different biological mechanisms may be involved.
ACCESSION #
79930549

 

Related Articles

  • Sex Differences in the Association between Serum Levels of Testosterone and Frailty in an Elderly Population: The Toledo Study for Healthy Aging. Carcaillon, Laure; Blanco, Carmen; Alonso-Bouz�n, Cristina; Alfaro-Acha, Ana; Garcia-Garc�a, Francisco-Jose; Rodriguez-Ma�as, Leocadio // PLoS ONE;Mar2012, Vol. 7 Issue 3, p1 

    Background: Age-associated decline in testosterone levels represent one of the potential mechanisms involved in the development of frailty. Although this association has been widely reported in older men, very few data are available in women. We studied the association between testosterone and...

  • The New Science of Sex. Murray, Iain // American Enterprise;Sep2003, Vol. 14 Issue 6, p34 

    Deals with the findings of research on the differences of men and women based on their brains and genes. Effect of testosterone in animals and humans; Influence of social movement on testosterone; Role of genetics in sex.

  • Sex Differences in Jealousy in Response to Actual Infidelity. Edlund, John E.; Heider, Jeremy D.; Scherer, Cory R.; Farc, Maria-Magdalena; Sagarin, Brad J. // Evolutionary Psychology;2006, Vol. 4, p462 

    The present studies address two criticisms of the theory of evolved sex differences in jealousy: (a) that the sex difference in jealousy emerges only in response to hypothetical infidelity scenarios, and (b) that the sex difference emerges only using forced-choice measures. In two separate...

  • Sex Differences in Physical and Indirect Aggression: A Developmental Perspective. Côté, Sylvana M. // European Journal on Criminal Policy & Research;2007, Vol. 13 Issue 3/4, p183 

    Males generally use aggression more often than females. However, the magnitude of difference between the sexes varies widely according to the type of aggression that is considered, and according to the developmental period studied. Taking a developmental perspective, this paper reviews research...

  • Sex differences in slow-wave electroencephalographic activity (SWA) in adolescent depression. Lopez, Jorge; Hoffmann, Robert; Emslie, Graham; Armitage, Roseanne // Mental Illness (2036-7457);2012, Vol. 4 Issue 1, p15 

    Sleep disturbances, present in more than 90% of major depressive disorder (MDD) patients, are moderated by sex in adult MDD. In particular, slow-wave electroencephalographic activity (SWA; 0.5-4 Hz) accumulation is low and dissipation impaired. This SWA abnormality in depressed adult males does...

  • Sex Differences, Sex-Role Orientation, and Reward Allocations. Olejnik, Anthony B.; Tompkins, Brigitte; Heinbuck, Claudia // Sex Roles;Jul82, Vol. 8 Issue 7, p711 

    In study 1, 52 male and 52 female undergraduates allocated rewards to pairs of children for their performances in team and competitive situations. Males allocated rewards more "equitably," especially when allocating to boys in competition, while females allocated rewards more "equally." Boys,...

  • Censorship vs. Sex Study.  // Ladder;Apr58, Vol. 2 Issue 7, p14 

    This article focuses on the distinction between censorships and sex research. The author examines the importance of allowing freedom of study and the difficulties inherent in the study of sexual differences in man. Definition of sexual psychopaths.

  • AGE EFFECTS IN EARWITNESS RECALL OF A NOVEL CONVERSATION. Ling, Jonathan; Coombe, Allison // Perceptual & Motor Skills;Jun2005 Part1, Vol. 100 Issue 3, p774 

    Recall of conversation is an important part of memory for events. Previous studies have focused predominantly on adults, In the present study, 195 participants ages 11 to 63 years listened to a novel audiotaped conversation. They were not informed they would later have to recall elements of this...

  • Social inequalities and representations of differences between the sexes. Poeschl, Gabrielle; Mürias, Cláudia; Costa, Eleonora // Analise Social;jul-sep2004, Vol. 39 Issue 171, p365 

    This article focuses on differences between the sexes and describes the opinions gathered on this by means of semi-structured interviews. The established relationship in the literature, between social position and personality traits, seems lacking in the representations of those interviewed, but...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics