TITLE

A 6 Week Randomized Double-Blind Placebo-Controlled Trial of Ziprasidone for the Acute Depressive Mixed State

AUTHOR(S)
Patkar, Ashwin; Gilmer, William; Chi-un Pae; Vöhringer, Paul A.; Ziffra, Michael; Pirok, Edward; Mulligan, Molly; Filkowski, Megan M.; Whitham, Elizabeth A.; Holtzman, Niki S.; Thommi, Sairah B.; Logvinenko, Tanya; Loebel, Antony; Masand, Prakash; Nassir Ghaemi, S.
PUB. DATE
April 2012
SOURCE
PLoS ONE;Apr2012, Vol. 7 Issue 4, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: To examine the efficacy of ziprasidone vs. placebo for the depressive mixed state in patients with bipolar disorder type II or major depressive disorder (MDD). Methods: 73 patients were randomized in a double-blinded, placebo-controlled study to ziprasidone (40-160 mg/d) or placebo for 6 weeks. They met DSM-IV criteria for a major depressive episode (MDE), while also meeting 2 or 3 (but not more nor less) DSM-IV manic criteria. They did not meet DSM-IV criteria for a mixed or manic episode. Baseline psychotropic drugs were continued unchanged. The primary endpoint measured was Montgomery- Åsberg Depression Rating Scale (MADRS) scores over time. The mean dose of ziprasidone was 129.7±45.3 mg/day and 126.1±47.1 mg/day for placebo. Results: The primary outcome analysis indicated efficacy of ziprasidone versus placebo (p = 0.0038). Efficacy was more pronounced in type II bipolar disorder than in MDD (p = 0.036). Overall ziprasidone was well tolerated, without notable worsening of weight or extrapyramidal symptoms. Conclusions: There was a statistically significant benefit with ziprasidone versus placebo in this first RCT of any medication for the provisional diagnostic concept of the depressive mixed state.
ACCESSION #
79917348

 

Related Articles

  • A 6 Week Randomized Double-Blind Placebo-Controlled Trial of Ziprasidone for the Acute Depressive Mixed State. Patkar, Ashwin; Gilmer, William; Chi-un Pae; V�hringer, Paul A.; Ziffra, Michael; Pirok, Edward; Mulligan, Molly; Filkowski, Megan M.; Whitham, Elizabeth A.; Holtzman, Niki S.; Thommi, Sairah B.; Logvinenko, Tanya; Loebel, Antony; Masand, Prakash; Nassir Ghaemi, S. // PLoS ONE;Apr2012, Vol. 7 Issue 4, p1 

    Objective: To examine the efficacy of ziprasidone vs. placebo for the depressive mixed state in patients with bipolar disorder type II or major depressive disorder (MDD). Methods: 73 patients were randomized in a double-blinded, placebo-controlled study to ziprasidone (40-160 mg/d) or placebo...

  • Adjunctive Aripiprazole Versus Placebo for Antipsychotic-Induced Hyperprolactinemia: Meta-Analysis of Randomized Controlled Trials. Li, Xianbin; Tang, Yilang; Wang, Chuanyue // PLoS ONE;Aug2013, Vol. 8 Issue 8, p1 

    Objective: To compare the safety and efficacy of adjunctive aripiprazole versus placebo for antipsychotic-induced hyperprolactinemia. Methods: Population: adult patients presenting with antipsychotic-induced hyperprolactinemia diagnosed by prolactin level with or without prolactin-related...

  • Efficacy of Venlafaxine for Symptomatic Relief in Young Adult Patients With Functional Chest Pain: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial. Hyuk Lee; Jeong Hwan Kim; Byung-Hoon Min; Jun Haeng Lee; Hee Jung Son; Kim, Jae J.; Jong Chul Rhee; Young Ju Suh; Seonwoo Kim; Poong-Lyul Rhee // American Journal of Gastroenterology;Jul2010, Vol. 105 Issue 7, p1504 

    OBJECTIVES:Esophageal hypersensitivity is currently believed to have a crucial role in the pathogenesis of functional chest pain (FCP). The aim of this study was to evaluate the clinical efficacy of venlafaxine, a serotonin–norepinephrine reuptake inhibitor (SNRI), for FCP in young adult...

  • Combination of Acupuncture and Fluoxetine for Depression: A Randomized, Double-Blind, Sham-Controlled Trial. Wen-Jing Zhang; Xin-Bo Yang; Bao-Liang Zhong // Journal of Alternative & Complementary Medicine;Aug2009, Vol. 15 Issue 8, p837 

    Background and objective: The current pharmacological management of depression remains limited. The aim of this study was to assess the efficacy and safety of acupuncture in combination with fluoxetine as an intervention for major depressive disorder (MDD). Subjects and interventions: A total of...

  • A Meta-Analysis of Randomised Placebo-Controlled Treatment Trials for Depression and Anxiety in Parkinson’s Disease. Troeung, Lakkhina; Egan, Sarah J.; Gasson, Natalie // PLoS ONE;Nov2013, Vol. 8 Issue 11, p1 

    Background: Psychopharmacotherapy currently constitutes the first-line treatment for depression and anxiety in Parkinson’s disease (PD) however the efficacy of antidepressant treatments in PD is unclear. Several alternative treatments have been suggested as potentially more viable...

  • The antidepressant debate. Moncrieff, Joanna // British Journal of Psychiatry;Mar2002, Vol. 180, p193 

    The author reflects on the debate in the medical literature concerning the efficacy of antidepressant drugs. She discloses that several studies and researches had proven already that the intake of antidepressants promote various adverse effect. She particularly regards its impact to depressive...

  • Continuation therapy with amitriptyline in depression. Coppen, A.; Ghose, K.; Montgomery, S.; Rama Rao, V. A.; Bailey, J.; Jorgensen, A. // British Journal of Psychiatry;Jul78, Vol. 133, p28 

    Thirty-two patients who had responded to amitriptyline (150 mg daily) when suffering from a depressive illness were allocated either to receive placebo or to remain on the same medication for one year. Plasma concentrations of the drug were regularly estimated. There was no correlation between...

  • When antidepressants don't work. Cowen, Philip // Pulse;2/9/2004, Vol. 64 Issue 6, p45 

    Explains the reasons on the ineffectiveness of antidepressants and how to solve the problem. Administration of the appropriate dosage; Recognition of dose-response curves; Decision of switching to an alternative drug; Consideration of using monoamine oxidase inhibitors; Augmentation strategies.

  • Are antidepressants as effective as claimed? No, they are not effective at all. Moncrieff, Joanna // Canadian Journal of Psychiatry;Feb2007, Vol. 52 Issue 2, p96 

    The article presents the author's comment on the efficacy of antidepressants in treating depressive symptoms. Several studies have indicated that people who are treated with antidepressants in randomized controlled trials do less well than those people who are not treated with them. Thus,...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics