Effect of a combination of oral midazolam and low-dose ketamine on anxiety, pain, swelling, and comfort during and after surgical extractions of mandibular third molars

Gupta, Rubina; Sharma, Kiran; Dhiman, Umesh Kumar
March 2012
Indian Journal of Dental Research;Mar/Apr2012, Vol. 23 Issue 2, following p292
Academic Journal
Purpose: To assess the clinical efficacy of a combination of oral midazolam plus low-dose ketamine for reducing anxiety during surgery and in preventing postoperative pain and swelling after the surgical extraction of third molars. Materials and Methods: Thirty patients requiring bilateral surgical extraction of mandibular third molars were included in this study. Prior to extraction of the tooth on the right side, a combination of oral midazolam and low-dose ketamine was given to the patient, while this protocol was not followed for extraction of the tooth on the left side. Anxiety levels were checked before surgery. The postoperative pain and swelling and patient's comfort with and without the premedication were compared. Results: Facial swelling on the postoperative days was lower on the right side than on the left. Pain scores at 30 minutes and 24 hours after surgery were significantly higher on the left side. Also, anxiety during the surgery was less and comfort levels were higher postoperatively when the combination of oral midazolam plus low-dose ketamine was used. Conclusions: Premedication with midazolam plus low-dose ketamine prior to surgical extraction of third molars can provide the patient with a comfortable procedure and good postoperative analgesia, with less swelling and significantly less pain.


Related Articles

  • WISDOM TEETH.  // Oklahoma Dental Association Journal;Dec2013, Vol. 104 Issue 9, p8 

    The article discusses about wisdom teeth. It mentions the reasons for wisdom teeth removal which include impaction, crowding of other teeth, and pain, and describes wisdom tooth extraction and dry socket. It outlines proper oral health care after wisdom teeth extraction which include avoiding...

  • Welcome wisdom. Perry, J. // British Dental Journal;11/23/2013, Vol. 215 Issue 10, p490 

    A letter to the editor is presented in response to article about the National Institute for Health and Care Excellence (NICE) guideline for the extraction of wisdom teeth that was published in the "British Dental Journal" (BDJ) and "Faculty Dental Journal."

  • Wisdom Teeth. Johnson, Madeline // Self;Nov98, Vol. 20 Issue 11, p94 

    Provides information on wisdom teeth extraction. Growth of the wisdom teeth; Possible effects of the impacted molars; Information on the study published in the `British Medical Journal' on prophylactic extraction; Comments from Mary Delsol, an oral and maxillofacial surgeon in private practice...

  • A LOSS OF wisdom. Little, Tommy // Cleo;Aug2014, p52 

    A personal narrative is presented which explores the author's experience of having his wisdom teeth extracted.

  • Teeth Extraction - Questions Frequently Asked.  // Oral Health (0974-3960);Dec2015, Vol. 9 Issue 12, p26 

    The article presents questions and answers related to teeth extraction including how long does it pain, care to be taken after the process of extraction, and need for the removal of wisdom teeth.

  • Corticosteroids decrease pain, swelling and trismus. Beirne, O. Ross // Evidence-Based Dentistry;Dec2013, Vol. 14 Issue 4, p111 

    Data sourcesPubMed, Scopus, Medline and Cochrane Oral Health Group's Trials Register, CENTRAL. Limited to English language.Study selectionRandomised control trials comparing preoperative steroids (in any formulation, dose or route) with placebo or no treatment in patients of any age, having...

  • Comparative Evaluation of Vital Parameters During Third Molar Surgery Under Local Anaesthesia with and without Sedative Agents. DHUVAD, JIGAR M.; KSHISAGAR, RAJESH A.; DHUVAD, MUKESH M. // Journal of Clinical & Diagnostic Research;Dec2014, Vol. 8 Issue 12, p57 

    Aims: To compare vital parameters; operator's comfort; and patient's satisfaction during impacted third molar removal under local anaesthesia, with or without sedative agents. Materials and Methods: Ninety patients undergoing elective third molar surgery were randomly divided into three groups...

  • Pain Relieve after Impacted Wisdom Teeth Extraction Dependent on the Drug Therapy.  // Collegium Antropologicum;Mar2011, Vol. 35 Issue 1, p133 

    No abstract available.

  • Ibuprofen is superior to paracetamol for pain relief following third molar removal. Ferraiolo, Debra M; Veitz-Keenan, Analia // Evidence-Based Dentistry;Dec2014, Vol. 15 Issue 4, p106 

    Data sourcesThe Cochrane Oral Health Group's Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase and the metaRegister of Controlled Trials were searched with no language restrictions.Study selectionRandomised controlled double-blinded clinical trials...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics