TITLE

Effect of teriparatide on pregnancy and lactation-associated osteoporosis with multiple vertebral fractures

AUTHOR(S)
Choe, Eun; Song, Je; Park, Kyeong; Seok, Hannah; Lee, Eun; Lim, Sung-Kil; Rhee, Yumie
PUB. DATE
September 2012
SOURCE
Journal of Bone & Mineral Metabolism;Sep2012, Vol. 30 Issue 5, p596
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Pregnancy and lactation-associated osteoporosis (PLO) is very rare, but it can cause severe vertebral compression fractures with disabling back pain. PLO patients have commonly been treated with antiresorptive agents against high bone turnover. There are, however, some concerns regarding the use of bisphosphonates: (1) PLO occurs during the first pregnancy with a high possibility of recurrence during the second pregnancy, (2) long-term outcomes of bisphosphonates in PLO are lacking, and (3) there is a possibility of bisphosphonates accumulated in the bones crossing the placenta. Therefore, alternative therapies must be considered. We analyzed the effect of teriparatide (TPTD), the human recombinant parathyroid hormone (1-34), for 18 months in three women with PLO. Multiple vertebral fractures with severe back pain appeared within 6 months after their first childbirth. Two of them had a family history of osteoporosis. Lactation was discontinued immediately after diagnosis of PLO. Calcium carbonate, cholecalciferol, and TPTD were prescribed. The back pain immediately resolved. Bone mineral density (BMD) increased by 14.5-25.0% (mean 19.5%) at the lumbar spine and by 9.5-16.7% (mean 13.1%) at the femoral neck, after 18 months of treatment. The final Z scores in these PLO patients were nearly normalized. Two women had a second baby without any complication. BMD significantly improved after 18 months of treatment with TPTD without further fractures. In conclusion, TPTD should be considered to avoid long-term morbidity in young patients with PLO and is highly encouraged for use in PLO patients with multiple vertebral fractures.
ACCESSION #
79824430

 

Related Articles

  • Bisphosphonates in pregnancy and lactation-associated osteoporosis. O'Sullivan, S.; Grey, A.; Singh, R.; Reid, I. // Osteoporosis International;Jul2006, Vol. 17 Issue 7, p1008 

    Introduction: Pregnancy and lactation-associated osteoporosis (PLO) is an uncommon condition characterized by the occurrence of fracture(s) during late pregnancy or the puerperium. The aetiology is uncertain, and its management and natural history poorly defined. Methods: We report a series of...

  • Bone Drugs Don't Stop All Fractures. Park, Alice // Time International (South Pacific Edition);3/7/2011, Vol. 177 Issue 9, p22 

    The article focuses on a Canadian study of bisphosphonate drugs such as Fosamax and Boniva utilized in reducing bone loss associated with osteoporosis that found there is a slightly higher risk of atypical fractures in femurs in women who take the drugs for over five years.

  • Bone Drugs Don't Stop All Fractures. Park, Alice // Time;3/7/2011, Vol. 177 Issue 9, p22 

    The article focuses on a Canadian study of bisphosphonate drugs such as Fosamax and Boniva utilized in reducing bone loss associated with osteoporosis that found there is a slightly higher risk of atypical fractures in femurs in women who take the drugs for over five years.

  • Bone Drugs Don't Stop All Fractures. Park, Alice // Time International (Atlantic Edition);3/7/2011, Vol. 177 Issue 9, p12 

    The article focuses on a Canadian study of bisphosphonate drugs such as Fosamax and Boniva utilized in reducing bone loss associated with osteoporosis that found there is a slightly higher risk of atypical fractures in femurs in women who take the drugs for over five years.

  • Atypical fractures not typical enough for definitive conclusions.  // Reactions Weekly;4/17/2010, Issue 1297, p3 

    The article discusses research which revealed a lack of association between bisphosphonate use and risk of atypical femoral fractures in elderly women receiving treatment for postmenopausal osteoporosis.

  • Atypical Femur Fractures in Patients Treated with Bisphosphonates: Identification, Management, and Prevention. Bubbear, Judith Sarah // Rambam Maimonides Medical Journal;Oct 2016, Vol. 7 Issue 4, p1 

    Osteoporosis is a common condition with significant health care costs. First-line therapy is with bisphosphonates, which have proven anti-fracture efficacy. Around 10 years after the introduction of bisphosphonates reports began to be published of atypical femoral fractures (AFFs) that may be...

  • A case report: pregnancy-induced severe osteoporosis with eight vertebral fractures. Ofluoglu, Onder; Ofluoglu, Demet // Rheumatology International;Dec2008, Vol. 29 Issue 2, p197 

    Osteoporosis associated with pregnancy and lactation is a rare condition. The prevalence, etiology and its pathogenesis is unknown. It causes one or more vertebral fractures with severe, prolonged back pain and height loss in affected women. Majority of the cases are seen in the third trimester...

  • Gebelik Ä°le Ä°liÅŸkili Osteoporoz. AKYÜZ, Gülseren; BAYINDIR, Özün // Turkish Journal of Physical Medicine & Rehabilitation / Turkiye ;Jun2013, Vol. 59 Issue 2, p145 

    Osteoporosis is a systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue. While osteoporosis is seen very often, osteoporosis in pregnancy is a rare clinical problem with unknown etiology and pathophysiology. Whether pregnancy is accidental...

  • Bisphosphonates in the management of thalassemia-associated osteoporosis: a systematic review of randomised controlled trials. Giusti, Andrea // Journal of Bone & Mineral Metabolism;Nov2014, Vol. 32 Issue 6, p606 

    Bisphosphonates are potent inhibitors of bone resorption, widely used for the management of osteoporosis and fracture prevention. Recent evidence suggests that bisphosphonates may have beneficial effects in the treatment of thalassemia-associated osteoporosis, a complex and multifactorial...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics