Computational Fluid Dynamics of Developing Avian Outflow Tract Heart Valves

Bharadwaj, Koonal; Spitz, Cassie; Shekhar, Akshay; Yalcin, Huseyin; Butcher, Jonathan
October 2012
Annals of Biomedical Engineering;Oct2012, Vol. 40 Issue 10, p2212
Academic Journal
Hemodynamic forces play an important role in sculpting the embryonic heart and its valves. Alteration of blood flow patterns through the hearts of embryonic animal models lead to malformations that resemble some clinical congenital heart defects, but the precise mechanisms are poorly understood. Quantitative understanding of the local fluid forces acting in the heart has been elusive because of the extremely small and rapidly changing anatomy. In this study, we combine multiple imaging modalities with computational simulation to rigorously quantify the hemodynamic environment within the developing outflow tract (OFT) and its eventual aortic and pulmonary valves. In vivo Doppler ultrasound generated velocity profiles were applied to Micro-Computed Tomography generated 3D OFT lumen geometries from Hamburger-Hamilton (HH) stage 16-30 chick embryos. Computational fluid dynamics simulation initial conditions were iterated until local flow profiles converged with in vivo Doppler flow measurements. Results suggested that flow in the early tubular OFT (HH16 and HH23) was best approximated by Poiseuille flow, while later embryonic OFT septation (HH27, HH30) was mimicked by plug flow conditions. Peak wall shear stress (WSS) values increased from 18.16 dynes/cm at HH16 to 671.24 dynes/cm at HH30. Spatiotemporally averaged WSS values also showed a monotonic increase from 3.03 dynes/cm at HH16 to 136.50 dynes/cm at HH30. Simulated velocity streamlines in the early heart suggest a lack of mixing, which differed from classical ink injections. Changes in local flow patterns preceded and correlated with key morphogenetic events such as OFT septation and valve formation. This novel method to quantify local dynamic hemodynamics parameters affords insight into sculpting role of blood flow in the embryonic heart and provides a quantitative baseline dataset for future research.


Related Articles

  • Hemodynamic impacts of left coronary stenosis: A patient-specific analysis. CHAICHANA, THANAPONG; SUN, ZHONGHUA; JEWKES, JAMES // Acta of Bioengineering & Biomechanics;2013, Vol. 15 Issue 3, p107 

    This study analyses the hemodynamic variations surrounding stenoses located at the left coronary bifurcation, and their influence on the wall shear stress (WSS) in realistic coronary geometries. Four patients with suspected coronary artery disease were chosen, and coronary models were...

  • The Role of Computational Fluid Dynamics in the Management of Unruptured Intracranial Aneurysms: A Clinicians' View. Singh, Pankaj K.; Marzo, Alberto; Coley, Stuart C.; Berti, Guntram; Bijlenga, Philippe; Lawford, Patricia V.; Villa-Uriol, Mari-Cruz; Rufenacht, Daniel A.; McCormack, Keith M.; Frangi, Alejandro; Patel, Umang J.; Hose, D. Rodney // Computational Intelligence & Neuroscience;2009, Special section p1 

    Objective. The importance of hemodynamics in the etiopathogenesis of intracranial aneurysms (IAs) is widely accepted. Computational fluid dynamics (CFD) is being used increasingly for hemodynamic predictions. However, along with the continuing development and validation of these tools, it is...

  • Trans-esophageal echocardiography for tricuspid and pulmonary valves. Prabhu, Mahesh R. // Annals of Cardiac Anaesthesia;Jul2009, Vol. 12 Issue 2, following p176 

    Transesophageal echocardiography has been shown to provide unique information about cardiac anatomy, function, hemodynamics and blood flow and is relatively easy to perform with a low risk of complications. Echocardiographic evaluation of the tricuspid and pulmonary valves can be achieved with...

  • Numerical Modeling of a Two Dimensional Mitral Heart Valve. Deep, Debanjan; Hasan, Mahmudul; Roy, Lalit // International Review of Mechanical Engineering;Jul2010, Vol. 4 Issue 5, p620 

    The pressure and velocity induced by the leaflet motion during both the closing and the opening phases of MITRAL valve have been computed. Detailed flow dynamic analysis in the vicinity of the leaflets and the housing during the closing and opening phases is of interest of this thesis. Two...

  • Virtual Treatment of Basilar Aneurysms Using Shape Memory Polymer Foam. Ortega, J.; Hartman, J.; Rodriguez, J.; Maitland, D. // Annals of Biomedical Engineering;Apr2013, Vol. 41 Issue 4, p725 

    Numerical simulations are performed on patient-specific basilar aneurysms that are treated with shape memory polymer (SMP) foam. In order to assess the post-treatment hemodynamics, two modeling approaches are employed. In the first, the foam geometry is obtained from a micro-CT scan and the...

  • Computational Simulation of a Mitral Heart Valve. Hasan, Mahmudul; Deep, Debanjan; Roy, Lalit // International Review of Mechanical Engineering;Jul2010, Vol. 4 Issue 5, p615 

    Unsteady blood flow passing over the bi-leaflet valve produces varying pressure and velocities at atrial and ventricular sections of heart chamber. These pressure and velocity distributions especially at opening and closing phases of the valve are of concern of this thesis. Three dimensional...

  • The effect of aneurysm geometry on the intra-aneurysmal flow condition. Tateshima, Satoshi; Chien, Aichi; Sayre, James; Cebral, Juan; Viñuela, Fernando // Neuroradiology;Dec2010, Vol. 52 Issue 12, p1135 

    Introduction: Various anatomical parameters affect on intra-aneurysmal hemodynamics. Nevertheless, how the shapes of real patient aneurysms affect on their intra-aneurysmal hemodynamics remains unanswered. Methods: Quantitative computational fluid dynamics simulation was conducted using eight...

  • Commentary: Computational Modeling of Contemporary Stent-Grafts. Doyle, Barry; Sun, Zhonghua; Jansen, Shirley; Norman, Paul // Journal of Endovascular Therapy (Sage Publications Inc.);Aug2015, Vol. 22 Issue 4, p591 

    An introduction is presented in which the author focuses on computational modelling of blood flow through different configurations of fenestrated (FSGs) and branched stent-grafts (BSGs), and discusses the flow rates and displacement forces on the stent-graft.

  • Thoracic Artificial Lung Impedance Studies Using Computational Fluid Dynamics and In Vitro Models. Schewe, Rebecca; Khanafer, Khalil; Orizondo, Ryan; Cook, Keith // Annals of Biomedical Engineering;Mar2012, Vol. 40 Issue 3, p628 

    Current thoracic artificial lungs (TALs) possess blood flow impedances greater than the natural lungs, resulting in abnormal pulmonary hemodynamics when implanted. This study sought to reduce TAL impedance using computational fluid dynamics (CFD). CFD was performed on TAL models with inlet and...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics