Lead Bone Toxicity in Growing Rats Exposed to Chronic Intermittent Hypoxia

Conti, María; Bozzini, Clarisa; Facorro, Graciela; Lee, Ching; Mandalunis, Patricia; Piehl, Lidia; Piñeiro, Adriana; Terrizzi, Antonela; Martínez, María
October 2012
Bulletin of Environmental Contamination & Toxicology;Oct2012, Vol. 89 Issue 4, p693
Academic Journal
Lead chronic intoxication under hypoxic conditions revealed growth retardation in growing rats and damages on femoral and mandibular bones that predispose to fractures. These findings aimed us to investigate if bone material and geometric properties, bone mass in terms of histomorphometry or antioxidant capacity are also impaired in such experimental model. Combined treatments significantly reduced hemimandible cross sectional geometry and intrinsic stiffness (−16 % and −34 %); tibia and hemimandible bone volume (−45 % and −40 %) and growth plate cartilage thickness (−19 %). These results show a previously unreported toxic effect of lead on mandible however, longer studies should be necessary to evaluate if an adaptation of bone architecture to maintain structural properties may occur and if the oxidative stress can be identified as the primary contributory agent in the pathogenesis of lead poisoning.


Related Articles

  • Induction of oxidative stress by low doses of lead in human hepatic cell line WRL-68. Hernández-Franco, Pablo; Silva, Martín; Valverde, Mahara; Rojas, Emilio // BioMetals;Oct2011, Vol. 24 Issue 5, p951 

    Even though the molecular mechanisms by which lead induces toxicity and cancer have been intensely studied for many years, its carcinogenic mechanisms are not well understood yet. Several possible mechanisms have been examined to gain understanding on the carcinogenic properties of lead, which...

  • Effect of Lead on Oxidative Stress, Na+K+ATPase Activity and Mitochondrial Electron Transport Chain Activity of the Brain of Clarias batrachus L. Maiti, Arpan Kumar; Saha, Nimai Chandra; Paul, Goutam // Bulletin of Environmental Contamination & Toxicology;Jun2010, Vol. 84 Issue 6, p672 

    The present invivo study was designed to elucidate the toxic effect of lead on oxidative stress, Na+K+ATPase and mitochondrial electron transport chain activity of the brain of Clarias batrachus. The fish were exposed to 10 and 20% of the derived 96 h LC50 value, 37.8 and 75.6 mg L−1,...

  • Effect of Glycine on Lead Mobilization, Lead-Induced Oxidative Stress, and Hepatic Toxicity in Rats. Alcaraz-Contreras, Yolanda; Garza-Oca˜nas, Lourdes; Carca˜no-D´ıaz, Katya; Ram´ırez-G´omez, X´ochitl Sof´ıa // Journal of Toxicology;2011, p1 

    The effectiveness of glycine in treating experimental lead intoxication was examined in rats. Male Wistar rats were exposed to 3 g/L lead acetate in drinking water for 5 weeks and treated thereafter with glycine (100 and 500 mg/kg, orally) once daily for 5 days or glycine (1000 mg/kg, orally)...

  • Protection by sildenafil and theophylline of lead acetate-induced oxidative stress in rat submandibular gland and saliva. Abdollahi, Mohammad; Fooladian, Fatemeh; Emami, Bita; Zafari, Khatereh; Bahreini-Moghadam, Arezou // Human & Experimental Toxicology;Nov2003, Vol. 22 Issue 11, p587 

    The role of oxidative stress in lead toxicity has been proposed in many organs, however, no study has been performed in the salivary glands, which are important parts of the gastrointestinal tract with a high implication in health of the whole body. Recently, it has been proposed that increasing...

  • Glycine betaine-induced lead toxicity tolerance related to elevated photosynthesis, antioxidant enzymes suppressed lead uptake and oxidative stress in cotton. Saima Aslam BHARWANA; ALI, Shafaqat; Muhammad Ahsan FAROOQ; IQBAL, Naeem; HAMEED, Amjad; ABBAS, Farhat; Muhammad Sajid Aqeel AHMAD // Turkish Journal of Botany;Feb2014, Vol. 38 Issue 2, p281 

    Anthropogenic activities contaminate soils with heavy metal concentrations including lead (Pb), cadmium (Cd), copper (Cu), and chromium (Cr). Pb has higher potential for ready accumulation, sedimentation, and poisoning of the soil than other heavy metals. The present study was conducted to...

  • N-ACETYL-CYSTEINE PROTECTS AGAINST DNA DAMAGE ASSOCIATED WITH LEAD TOXICITY IN HEPG2 CELLS. Yedjou, Clement G.; Tchounwou, Christine K.; Haile, Samuel; Edwards, Falicia; Tchounwou, Paul B. // Ethnicity & Disease;Winter2010 Supplement, Vol. 20, pS1-101 

    Lead toxicity has been associated with its ability to interact and damage DNA. However, its molecular mechanisms of action are not fully understood. In vitro studies in our laboratory indicated that lead nitrate (PbNO3) induces cytotoxicity and oxidative stress to human liver carcinoma (HepG2)...

  • The Level of Selenium and Oxidative Stress in Workers Chronically Exposed to Lead. Pawlas, Natalia; Dobrakowski, Michał; Kasperczyk, Aleksandra; Kozłowska, Agnieszka; Mikołajczyk, Agnieszka; Kasperczyk, Sławomir // Biological Trace Element Research;Mar2016, Vol. 170 Issue 1, p1 

    The possible beneficial role of selenium (Se) on the oxidative stress induced by lead (Pb) is still unclear in humans. Therefore, the aim of the present study was to explore the associations among the Se levels, chronic Pb exposure, oxidative stress parameters, and parameters characterizing the...

  • Water Spinach, Ipomoea aquatic (Convolvulaceae), Ameliorates Lead Toxicity by Inhibiting Oxidative Stress and Apoptosis. Dewanjee, Saikat; Dua, Tarun K.; Khanra, Ritu; Das, Shilpa; Barma, Sujata; Joardar, Swarnalata; Bhattacharjee, Niloy; Zia-Ul-Haq, M.; Jaafar, Hawa Z. E. // PLoS ONE;10/16/2015, Vol. 10 Issue 10, p1 

    Background: Ipomoea aquatica (Convolvulaceae), an aquatic edible plant, is traditionally used against heavy metal toxicity in India. The current study intended to explore the protective role of edible (aqueous) extract of I. aquatica (AEIA) against experimentally induced Pb-intoxication....

  • OXIDATIVE STRESS IN PAINTERS EXPOSED TO LOW LEAD LEVELS. MOHAMMAD, Imran Khan; MAHDI, Abbas Ali; RAVIRAJA, Aryapu; NAJMUL, Islam; IQBAL, Ahmad; THUPPIL, Venkatesh // Archives of Industrial Hygiene & Toxicology / Arhiv za Higijenu ;Sep2008, Vol. 59 Issue 3, p161 

    Lead toxicity is a public health problem particularly to the children and to occupationally exposed adults. Evidence is mounting successively regarding the adverse health effects of lead at low levels. This study was undertaken to assess the antioxidant status of lead-exposed residential and...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics