TITLE

Stress-Response Protein Expression and DAF-16 Translocation were Induced in Tributyltin-Exposed Caenorhabditis elegans

AUTHOR(S)
Wang, Yun; Jian, Fenglei; Wu, Jieyu; Wang, Shunchang
PUB. DATE
October 2012
SOURCE
Bulletin of Environmental Contamination & Toxicology;Oct2012, Vol. 89 Issue 4, p704
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Exposure to tributyltin (TBT) with graded sublethal doses (0, 1, 10, 50 and 200 nM) resulted in the release of reactive oxygen species (ROS) and DNA damage in the nematode Caenorhabditis elegans. After the worms carrying transgenic reporters were exposed to TBT, the expressions of superoxide dismutase (SOD-3), glutathione S-transferase (GST-4) and heat shock proteins (HSP-4, HSP-16.2 and HSP-70) were semi-quantified after exposure. The results indicated that TBT caused dose-dependent induction of SOD-3, GST-4, HSP-4 and HSP-70. Furthermore, TBT exposure also induced DAF-16 translocation from cytoplasm to nucleus. The results implicated that C. elegans might be a potential animal model for TBT level monitoring and toxicity assessment.
ACCESSION #
79823968

 

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