Sodium Sulfite Enhances Rhinovirus-Induced Chemokine Production in Airway Epithelial Cells

Chun, Yoon; Kim, Hyun; Lee, Huisu; Won, Sulmui; Yoon, Jong-seo; Kim, Jin; Lee, Joon
October 2012
Bulletin of Environmental Contamination & Toxicology;Oct2012, Vol. 89 Issue 4, p718
Academic Journal
We investigated the effects of sodium sulfite (NaSO) on rhinovirus (RV)-induced chemokine production in A549 airway epithelial cells. Our results demonstrated that the treatment of A549 cells with 2,500 μM NaSO enhanced the mRNA expression of RV-induced interleukin (IL)-8 1.8 fold ( p = 0.025); and regulated on activation, normal T cell expressed and secreted (RANTES), 2.9 fold ( p = 0.025). Moreover, the secretion of IL-8, RANTES, and interferon-γ-inducible protein (IP)-10 was increased in a statistically significant manner without affecting cell viability and RV replication. Our results suggest that NaSO may potentiate RV infection by enhancing chemokine production.


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