TITLE

The impact of statin use on pneumonia risk and outcome: a combined population-based casecontrol and cohort study

AUTHOR(S)
Gunnar Nielsen, Anders; Beck Nielsen, Rikke; Hammerich Riis, Anders; Paaske, S�ren; Toft S�rensen, Henrik; Wernich Tohmsen, Reimar
PUB. DATE
July 2012
SOURCE
Critical Care;2012, Vol. 16 Issue 4, p11418
SOURCE TYPE
Periodical
DOC. TYPE
Article
ABSTRACT
Abstract: Introduction: The impact of statin use on pneumonia risk and outcome remains unclear. We therefore examined this risk in a population-based case-control study and did a 5-year update of our previous 30-day mortality analyses. Methods: We identified 70,953 adults with a first-time hospitalization for pneumonia between 1997 and 2009 in Northern Denmark. Ten age- and sex-matched population controls were selected for each pneumonia patient. To control for potential confounders, we retrieved individual-level data on other medications, comorbidities, recent surgery, socioeconomic indicators, influenza vaccination, and other markers of frailty or health awareness from medical databases. We followed all pneumonia patients for 30 days after hospital admission. Results: A total of 7,223 pneumonia cases (10.2%) and 64 523 controls (9.1%) were statin users before admission, corresponding to an age- and sex-matched odds ratio (OR) of 1.17 (95% confidence interval [CI]: 1.14-1.21). After controlling for higher comorbidity and a wide range of other potential confounders, the adjusted OR for pneumonia associated with current statin use dropped to 0.80 (95% CI: 0.77-0.83). Previous statin use was not associated with decreased pneumonia risk (adjusted OR = 0.97, 95% CI: 0.91-1.02). Decreased risk remained significant after further adjustment for frailty and health awareness markers.The prevalence of statin use among Danish pneumonia patients increased from 1% in 1997 to 24% in 2009. Thirty daymortality following pneumonia hospitalization was 11.3% among statin users versus 15.1% among nonusers. This corresponded to a 27% reduced mortality rate (adjusted hazard ratio = 0.73, 95% CI: 0.67-0.79), corroborating our earlier findings.Conclusions: Current statin use was associated with both a decreased risk of hospitalization for pneumonia and lower 30-day mortality following pneumonia
ACCESSION #
79822993

 

Related Articles

  • HOSPITALS TREAT MORE LUNG INFECTIONS.  // Modern Healthcare;12/12/2005, Vol. 35 Issue 50, p9 

    The article reports on an increase in the rate of pneumonia hospitalizations per 1,000 population in the U.S. in 2005. It has increased by 29% among U.S. citizens aged 65 and older. There are 2.3 million cases between 2000 and 2002 according to a report published in the "Journal of the American...

  • Human Metapneumovirus-associated Atypical Pneumonia and SARS. Chan, Paul K. S.; Ka-Fai To; Wu, Alan; Tse, Gary M. K.; Kui-Fat Chan; Siu-Fai Lui; Sung, Joseph J. Y.; Tam, John S.; Tomlinson, Brian // Emerging Infectious Diseases;Mar2004, Vol. 10 Issue 3, p497 

    Acute pneumonia developed in a previously healthy man during the outbreak of severe acute respiratory syndrome (SARS) in southern China in March 2003. Antibiotic treatment was ineffective, and he died 8 days after illness onset. Human metapneumovirus was isolated from lung tissue. No other...

  • pneumonia. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p615 

    An encyclopedia entry for "pneumonia" is presented. It refers to the inflammation of the lungs due to infection. It is caused by adenovirus or respiratory synctial virus. One form is aspiration pneumonia which occurs in people whose cough reflex is not functioning. The symptoms, complications,...

  • Respiratory viruses in exacerbations of chronic obstructive pulmonary disease requiring hospitalisation: a case-control study. Rohde, G.; Wiethege, A.; Borg, I.; Kauth, M.; Bauer, T. T.; Gillissen, A.; Bufe, A.; Schultze-Werninghaus, G. // Thorax;Jan2003, Vol. 58 Issue 1, p37 

    Background: Acute exacerbations of chronic obstructive pulmonary disease (AE-COPD) are a common cause of hospital admission. Many exacerbations are believed to be due to upper and/or lower respiratory tract viral infections, but the incidence of these infections in patients with COPD is still...

  • Avian influenza, China.  // Weekly Epidemiological Record;11/25/2005, Vol. 80 Issue 47, p409 

    This article informs that on November 7, 2005, the Ministry of Health in China confirmed the country's first 2 human cases of infection with the H5N1 avian influenza virus. The first case is a 9-year-old boy from the southern province of Hunan. He was hospitalized with respiratory symptoms on 17...

  • Favorable outcome of pneumonia due to Panton–Valentine leukocidin-producing Staphylococcus aureus associated with hematogenous origin and absence of flu-like illness. Alonso-Tarrés, C.; Villegas, M. L.; de Gispert, F. J.; Cortés-Lletget, M. C.; Plarromaní, A. Rovira; Etienne, J. // European Journal of Clinical Microbiology & Infectious Diseases;Nov2005, Vol. 24 Issue 11, p756 

    Reported here is what is believed to be the first case of community-acquired pneumonia caused by a Panton–Valentine leukocidin-producing strain of Staphylococcus aureus in Spain. Although lung infections caused by S. aureus strains carrying this powerful leukocidin gene are associated...

  • Detection of the New Human Coronavirus HKU1: A Report of 6 Cases. Vabret, Astrid; Dina, Julia; Gouarin, Stéphanie; Petitjean, Joëlle; Corbet, Sandrine; Freymuth, François // Clinical Infectious Diseases;3/1/2006, Vol. 42 Issue 5, p634 

    Background. Human coronavirus HKU1 (HCoV-HKU1), a new group 2 coronavirus, was first characterized in 2005 from 2 adults with pneumonia in Hong Kong, China. To the best of our knowledge, there is no other report to date about the detection of this new virus. We report a molecular method allowing...

  • Severe Acute Respiratory Syndrome (SARS) in Health Care Workers. Ho, A.S.; Sung, J.J.Y.; Chan-Yeung, M. // Annals of Internal Medicine;10/7/2003, Vol. 139 Issue 7, pI47 

    Severe acute respiratory syndrome (SARS) is a serious disease caused by a virus called coronavirus. Symptoms include fever, body aches and pains, cough, and trouble breathing. Lung inflammation with pneumonia is often severe, and patients may need machines to help them breathe. About 10% of...

  • Pulmonary complications of liver transplantation: radiological appearance and statistical evaluation of risk factors in 300 cases. Golfieri, R.; Giampalma, E.; Morselli Labate, A. M.; d'Arienzo, P.; Jovine, E.; Grazi, G. L.; Mazziotti, A.; Maffei, M.; Muzzi, C.; Tancioni, S.; Sama, C.; Cavallari, A.; Gavelli, G. // European Radiology;Jul2000, Vol. 10 Issue 7, p1169 

    The aim of this study was to evaluate the incidence, radiographic appearance, time of onset, outcome and risk factors of non-infectious and infectious pulmonary complications following liver transplantation. Chest X-ray features of 300 consecutive patients who had undergone 333 liver transplants...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics