TITLE

Identification and Dissection of Four Major QTL Affecting Milk Fat Content in the German Holstein-Friesian Population

AUTHOR(S)
Xiaolong Wang; Christine Wurmser; Pausch, Hubert; Simone Jung; Reinhardt, Friedrich; Tetens, Jens; Thaller, Georg; Fries, Ruedi
PUB. DATE
July 2012
SOURCE
PLoS ONE;Jul2012, Vol. 7 Issue 7, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Milk composition traits exhibit a complex genetic architecture with a small number of major quantitative trait loci (QTL) explaining a large fraction of the genetic variation and numerous QTL with minor effects. In order to identify QTL for milk fat percentage (FP) in the German Holstein-Friesian (HF) population, a genome-wide association study (GWAS) was performed. The study population consisted of 2327 progeny-tested bulls. Genotypes were available for 44,280 SNPs. Phenotypes in the form of estimated breeding values (EBVs) for FP were used as highly heritable traits. A variance components-based approach was used to account for population stratification. The GWAS identified four major QTL regions explaining 46.18% of the FP EBV variance. Besides two previously known FP QTL on BTA14 (P = 8.91×10-198) and BTA20 (P = 7.03×10-12) within DGAT1 and GHR, respectively, we uncovered two additional QTL regions on BTA5 (P = 2.00×10-13) and BTA27 (P = 9.83×10-5) encompassing EPS8 and GPAT4, respectively. EPS8 and GPAT4 are involved in lipid metabolism in mammals. Re-sequencing of EPS8 and GPAT4 revealed 50 polymorphisms. Genotypes for five of them were inferred for the entire study population. Two polymorphisms affecting potential transcription factor binding sites of EPS8 (P = 1.40×10-12) and GPAT4 (P = 5.18×10-5), respectively, were highly significantly associated with the FP EBV. Our results provide evidence that alteration of regulatory sites is an important aspect of genetic variation of complex traits in cattle.
ACCESSION #
79784987

 

Related Articles

  • Genome-wide association and biological pathway analysis for milk-fat composition in Danish Holstein and Danish Jersey cattle. Buitenhuis, Bart; Janss, Luc L. G.; Poulsen, Nina A.; Larsen, Lotte B.; Larsen, Mette K.; Sørensen, Peter // BMC Genomics;2014, Vol. 15 Issue 1, p1548 

    Background: The milk fat profile of the Danish Holstein (DH) and Danish Jersey (DJ) show clear differences. Identification of the genomic regions, genes and biological pathways underlying the milk fat biosynthesis will improve the understanding of the biology underlying bovine milk fat...

  • Genetic Parameters and Trends of Milk and Fat Yield in Holstein's Dairy Cattle of West Provinces of Iran. Yaeghoobi, R.; Doosti, A.; Noorian, A. M.; Bahrami, A. M. // International Journal of Dairy Science;2011, Vol. 6 Issue 2, p142 

    Investigation of genetic parameters and trend of milk and fat yield traits is main goal of this study. This study used 2213 records of first lactation Holstein's dairy cattle of west provinces of Iran for estimate of genetic and phonotype trend. These data get from Animal Breeding Center from...

  • Improving accuracy of genomic prediction by genetic architecture based priors in a Bayesian model. Ning Gao; Jiaqi Li; Jinlong He; Guang Xiao; Yuanyu Luo; Hao Zhang; Zanmou Chen; Zhe Zhang // BMC Genetics;10/14/2015, Vol. 16, p1 

    Background: In recent years, with the development of high-throughput sequencing technology and the commercial availability of genotyping bead chips, more attention is being directed towards the utilization of abundant genetic markers in animal and plant breeding programs, human disease risk...

  • Genome-Wide Detection of Selective Signature in Chinese Holstein. Pan, Dunfei; Zhang, Shengli; Jiang, Jicai; Jiang, Li; Zhang, Qin; Liu, JianFeng // PLoS ONE;Mar2013, Vol. 8 Issue 3, p1 

    Selective signatures in whole genome can help us understand the mechanisms of selection and target causal variants for breeding program. In present study, we performed Extended Haplotype Homozygosity (EHH) tests to identify significant core regions harboring such signals in Chinese Holstein, and...

  • Untitled. Mackenzie, Gemma // Farmers Weekly;11/25/2011, Vol. 156 Issue 22, p28 

    The article reports on the warning for dairy farmers in Great Britain on the importance of daughter proofs as genomics comes to the fore of animal breeding, by Lucy Andrews of Holstein UK in November 2011. She advises farmers to lower their expectation of genomics and spread the risk over a...

  • New genomics service.  // New Zealand Dairy Exporter;Aug2012, Vol. 88 Issue 1, p165 

    The article provides information on HFBoost, a genomic testing service being offered by Holstein Friesian New Zealand and CRV Ambreed to all Holstein Friesian NZ members.

  • Comparison of Milk Fat Globule Membrane (MFGM) Proteins of Chianina and Holstein Cattle Breed Milk Samples Through Proteomics Methods. Murgiano, Leonardo; Timperio, Anna Maria; Zolla, Lello; Bongiorni, Silvia; Valentini, Alessio; Pariset, Lorraine // Nutrients;Dec2009, Vol. 1 Issue 2, p302 

    Identification of proteins involved in milk production is important to understand the biology of lactation. Many studies have advanced the understanding of mammary function and milk secretion, but the critical molecular mechanisms implicated in milk fat secretion is still incomplete. Milk Fat...

  • Genome Wide Association Study Identifies 20 Novel Promising Genes Associated with Milk Fatty Acid Traits in Chinese Holstein. Li, Cong; Sun, Dongxiao; Zhang, Shengli; Wang, Sheng; Wu, Xiaoping; Zhang, Qin; Liu, Lin; Li, Yanhua; Qiao, Lv // PLoS ONE;May2014, Vol. 9 Issue 5, p1 

    Detecting genes associated with milk fat composition could provide valuable insights into the complex genetic networks of genes underling variation in fatty acids synthesis and point towards opportunities for changing milk fat composition via selective breeding. In this study, we conducted a...

  • Holsteins in hot demand. Searle, Steve // New Zealand Dairy Exporter;Oct2011, Vol. 87 Issue 3, p118 

    The article discusses the growing international demand for New Zealand's Holstein cattle as of October 2011. It cites David Fullerton, a breeder in Waikato, who describes the growing profitability of his cows, and his expectations of more orders over the next three to four years. Fullerton said...

Share

Read the Article

Courtesy of NEW JERSEY STATE LIBRARY

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics