TITLE

Complex Patterns of Human Antisera Reactivity to Novel 2009 H1N1 and Historical H1N1 Influenza Strains

AUTHOR(S)
Carter, Donald M.; Hai-Rong Lu; Bloom, Chalise E.; Crevar, Corey J.; Cherry, Joshua L.; Lipman, David J.; Ross, Ted M.
PUB. DATE
July 2012
SOURCE
PLoS ONE;Jul2012, Vol. 7 Issue 7, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: During the 2009 influenza pandemic, individuals over the age of 60 had the lowest incidence of infection with approximately 25% of these people having pre-existing, cross-reactive antibodies to novel 2009 H1N1 influenza isolates. It was proposed that older people had pre-existing antibodies induced by previous 1918-like virus infection(s) that crossreacted to novel H1N1 strains. Methodology/Principal Findings: Using antisera collected from a cohort of individuals collected before the second wave of novel H1N1 infections, only a minority of individuals with 1918 influenza specific antibodies also demonstrated hemagglutination-inhibition activity against the novel H1N1 influenza. In this study, we examined human antisera collected from individuals that ranged between the ages of 1 month and 90 years to determine the profile of seropositive influenza immunity to viruses representing H1N1 antigenic eras over the past 100 years. Even though HAI titers to novel 2009 H1N1 and the 1918 H1N1 influenza viruses were positively associated, the association was far from perfect, particularly for the older and younger age groups. Conclusions/Significance: Therefore, there may be a complex set of immune responses that are retained in people infected with seasonal H1N1 that can contribute to the reduced rates of H1N1 influenza infection in older populations.
ACCESSION #
79784278

 

Related Articles

  • Genetic stability and linkage analysis of the 2009 influenza A(H1N1) virus based on sequence homology. Jun Lu; Dabin Liu; Wei Liu; Taoxing Shi; Yigang Tong; Wuchun Cao // Archives of Virology;Dec2009, Vol. 154 Issue 12, p1883 

    The 2009 swine-origin Influenza A virus subtype H1N1 (S-OIV) is generally believed to be a mixture of human, bird and swine viruses, resulting from multiple reassortments. The evolutionary origin of the S-OIV is of high interest but still remains obscure. In order to understand the evolution of...

  • Oseltamivir: Development of resistance in influenza virus A(H1N1)pdm09 infection: case report.  // Reactions Weekly;6/22/2019, Vol. 1758 Issue 1, p264 

    No abstract available.

  • Swine influenza: frequently asked questions.  // Weekly Epidemiological Record;5/1/2009, Vol. 84 Issue 18, p149 

    The article offers information concerning swine influenza, a highly communicable acute respiratory disease of pigs. It notes that the said disease is caused by one of several swine influenza A viruses in which commonly occur in the U.S. and Spain. Antiviral medications for swine influenza are...

  • Intrahost emergent dynamics of oseltamivir-resistant virus of pandemic influenza A (H1N1) 2009 in a fatally immunocompromised patient. Hamada, Nobuyuki; Imamura, Yutaka; Hara, Koyu; Kashiwagi, Takahito; Imamura, Yoshihiro; Nakazono, Yoko; Chijiwa, Katsumi; Watanabe, Hiroshi // Journal of Infection & Chemotherapy;Dec2012, Vol. 18 Issue 6, p865 

    The oseltamivir-resistant pandemic influenza virus A (2009 H1N1) with H275Y mutation in neuraminidase (NA) has been sporadically reported, and its wide spread remains a potential threat. Here we detected the uneven distribution of H275Y mutant virus in a patient who received a 21-day long-term...

  • Guinea Pig Model for Evaluating the Potential Public Health Risk of Swine and Avian Influenza Viruses. Yipeng Sun; Yuhai Bi; Juan Pu; Yanxin Hu; Jingjing Wang; Huijie Gao; Linqing Liu; Qi Xu; Yuanyuan Tan; Mengda Liu; Xin Guo; Hanchun Yang; Jinhua Liu // PLoS ONE;2010, Vol. 5 Issue 11, p1 

    Background: The influenza viruses circulating in animals sporadically transmit to humans and pose pandemic threats. Animal models to evaluate the potential public health risk potential of these viruses are needed. Methodology/Principal Findings: We investigated the guinea pig as a mammalian...

  • EMERGENCE OF NOVEL INFLUENZA A H1N1 VIRUS AS A PANDEMIC AGENT. Ravi, V. // Indian Journal of Medical Microbiology;Jul2009, Vol. 27 Issue 3, p179 

    The article focuses on the emergence of the influenza 2009 A/H1N1 virus. Accordingly, it provides information about A/H1N1 including its definition and causes. It compares A/H1N1 with other human respiratory viruses such as SARS virus and the H5N1 or the Avian flu. It also discusses the...

  • Secondary bacterial pneumonia due to Staphylococcus aureus complicating 2009 influenza A (H1N1) viral infection. Tsigrelis, C.; Mohammad, M.; Fraimow, H. S.; Dellinger, R. P.; Marchesani, D.; Reboli, A. C. // Infection;Jun2010, Vol. 38 Issue 3, p237 

    The article discusses two patients with influenza A (H1N1) viral infection complicated with the onset of secondary bacterial pneumonia due to Staphylococcus aureus in the U.S. It outlines the diagnostic examinations undertaken by the patients to determine the proper treatment of their condition....

  • Human infection with new influenza A (H1N1) virus: Mexico, update, March--May 2009.  // Weekly Epidemiological Record;6/5/2009, Vol. 84 Issue 23, p213 

    The article reports on the updates for human infection with new influenza A (H1N1) virus for March-May 2009 in Mexico. It states that there has been an outbreak of acte respiratory infections and there have been notification of a rapidly progressive severe pneumonia in the metropolitan of Mexico...

  • Continued dominance of pandemic A(H1N1) 2009 influenza in Victoria, Australia in 2010. Grant, Kristina A.; Franklin, Lucinda J.; Kaczmarek, Marlena; Hurt, Aeron C.; Kostecki, Renata; Kelly, Heath A.; Fielding, James E. // Western Pacific Surveillance & Response Journal;oct-dec2011, Vol. 2 Issue 4, p1 

    The 2010 Victorian influenza season was characterized by normal seasonal influenza activity and the dominance of the pandemic A(H1N1) 2009 strain. General Practice Sentinel Surveillance rates peaked at 9.4 ILI cases per 1000 consultations in week 36 for metropolitan practices, and at 10.5 ILI...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics