Functionalization of biomaterials surfaces using artificial extracellular matrices

Bierbaum, Susanne; Hintze, Vera; Scharnweber, Dieter
July 2012
Biomatter;Jul-Sep2012, Vol. 2 Issue 3, Special section p1
Academic Journal
Construction of biomaterials with the ability to guide cell function is a topic of high interest in biomaterial development. One approach is using components native to the ECM of the target tissue to generate in vitro a microenvironment that can also elicit specific responses in cells and tissues--an artificial ECM (aECM). The focus is on collagen as the basic material, which can be modified using a number of different glycoproteins, proteoglycans and glycosaminoglycans. Preparation, immobilization and the biochemical characteristics of such aECM are discussed, as well as the in vitro and in vivo response of cells and tissues, illustrating the potential of such matrices to direct cell fate.


Related Articles

  • The Characterization and Development of Bioactive Hydroxyapatite Coatings. Ong, J. L.; Appleford, M.; Oh, S.; Yang, Y.; Chen, W.-H.; Bumgardner, J. D.; Haggard, W. O. // JOM: The Journal of The Minerals, Metals & Materials Society (TM;Jul2006, Vol. 58 Issue 7, p67 

    Bioactive coatings are currently being plasma-sprayed on implant surfaces in order to optimize bone-implant interactions. However, there are problems with the existing coating process, such as poor interfacial adhesion strength, alteration of coating properties, and the lack of an existing...

  • The Effects of Surface Properties of Nanostructured Bone Repair Materials on Their Performances. Zhao, Feng; Wang, Jian; Guo, Hongjuan; Liu, Shaojun; He, Wei // Journal of Nanomaterials;5/20/2015, Vol. 2015, p1 

    Nanotechnology has been expected to be an extraordinarily promising method for bone repair. Meanwhile, the promise of nanobiomaterials for therapeutic applications has been widely reported, and a lot of studies have been made in terms of repairing bone using nanomaterials accompanied by rapid...

  • Immunogenicity of Injectable Collagen Implants. Sellem, Philippe H.; Caranzan, François R.; Bene, Marie C.; Faure, Gilbert C. // Journal of Dermatologic Surgery & Oncology;Nov87, Vol. 13 Issue 11, p1199 

    The presence of antibodies to bovine and human collagens used in injectable collagen implants (ICI) was investigated in 103 normal sera. Significant levels of spontaneous nonprecipitin antibodies were observed, suggesting that immunization to ICI compounds may preexist even in the absence of...

  • Protein Adsorption on Titanium Surface Functionalized with Bioactive Gelatin Methacrylate Hydrogel Coating. Guoxin Tan; Ying Tan; Chengyun Ning; Lin Zhang; Lei Zhou; Hang Wang // Advanced Materials Research;2014, Vol. 936, p663 

    Gelatin methacrylate (GelMA) hydrogel comprised of modified natural extracellular matrix (ECM) components, making it a potentially attractive material for surface modification. In this paper, we hypothesize that establishing a GelMA hydrogel coating on titanium surface will accelerate...

  • BIOACTIVE COATING OVER POLYMER-CERAMIC COMPOSITE - AN IDEAL SYNTHETIC BONE SUBSTITUTE. Bag, S.; Pal, S. // International Journal of Pharma & Bio Sciences;Oct-Dec2011, Vol. 2 Issue 4, p242 

    A biologically active material enables implants to bond with bone, which could significantly extend the lifetime of the artificial implants or other medical reconstructive devices. The bioactive coating adhere to the surface of the implant, binds with both implants and bone, promotes formation...

  • Improved collagen type I/III ratio at the interface of gentamicin-supplemented polyvinylidenfluoride mesh materials. Junge, Karsten; Klinge, Uwe; Rosch, Raphael; Lynen, Petra; Binnebösel, Marcel; Conze, Joachim; Mertens, Peter R.; Schwab, Robert; Schumpelick, Volker // Langenbeck's Archives of Surgery;Sep2007, Vol. 392 Issue 4, p465 

    Formation of recurrent inguinal and incisional hernia shows an underlying defect in the wound-healing process with an insufficient quality of scar formation. Even after mesh repair an altered collagen formation and insufficient mesh integration has been found as main reason for recurrences....

  • Does PRP enhance bone integration with grafts, graft substitutes, or implants? A systematic review. Roffi, Alice; Filardo, Giuseppe; Kon, Elizaveta; Marcacci, Maurilio // BMC Musculoskeletal Disorders;2013, Vol. 14 Issue 1, p1 

    Background Several bone implants are applied in clinical practice, but none meets the requirements of an ideal implant. Platelet-rich plasma (PRP) is an easy and inexpensive way to obtain growth factors in physiologic proportions that might favour the regenerative process. The aim of this review...

  • Effect of biological implant surface coatings on bone formation, applying collagen, proteoglycans, glycosaminoglycans and growth factors. Stadlinger, Bernd; Pilling, Eckart; Mai, Ronald; Bierbaum, Susanne; Berhardt, Ricardo; Scharnweber, Dieter; Eckelt, Uwe // Journal of Materials Science: Materials in Medicine;Mar2008, Vol. 19 Issue 3, p1043 

    The aim of the present study was to evaluate six different implant surface coatings with respect to bone formation. Being major structural components of the extracellular matrix, collagen, the non-collagenous components decorin/chondroitin sulphate (CS) and the growth factors TGF-β1/BMP-4...

  • Increased peri-ductal collagen micro-organization may contribute to raised mammographic density. McConnell, James C.; O'Connell, Oliver V.; Brennan, Keith; Weiping, Lisa; Howe, Miles; Joseph, Leena; Knight, David; O'Cualain, Ronan; Lim, Yit; Leek, Angela; Waddington, Rachael; Rogan, Jane; Astley, Susan M.; Gandhi, Ashu; Kirwan, Cliona C.; Sherratt, Michael J.; Streuli, Charles H. // Breast Cancer Research;1/8/2016, Vol. 18, p5 

    Background: High mammographic density is a therapeutically modifiable risk factor for breast cancer. Although mammographic density is correlated with the relative abundance of collagen-rich fibroglandular tissue, the causative mechanisms, associated structural remodelling and...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics