TITLE

TNF receptor family signaling in the development and functions of medullary thymic epithelial cells

AUTHOR(S)
Akiyama, Taishin; Shinzawa, Miho; Akiyama, Nobuko
PUB. DATE
August 2012
SOURCE
Frontiers in Immunology;Aug2012, Vol. 3, preceding p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Thymic epithelial cells (TECs) provide the microenvironment required for the development of T cells in the thymus. A unique property of medullary thymic epithelial cells (mTECs) is their expression of a wide range of tissue-restricted self-antigens, critically regulated by the nuclear protein Aire, which contributes to the selection of the self-tolerant T cell repertoire, thereby suppressing the onset of autoimmune diseases. The TNF receptor family protein receptor activator of NF-κB (RANK), CD40 and lymphotoxin β receptor (LtβR) regulate the development and functions of mTECs. The engagement of these receptors with their specific ligands results in the activation of the NF-κB family of transcription factors. Two NF-κB activation pathways, the classical and non-classical pathways, promote the development of mature mTECs induced by these receptors. Consistently, TNF receptor-associated factor (TRAF6), the signal transducer of the classical pathway, and NF-κB inducing kinase (NIK), the signal transducer of the non-classical pathway, are essential for the development of mature mTECs. This review summarizes the current understanding of how the signaling by the TNF receptor family controls the development and functions of mTEC.
ACCESSION #
79653092

 

Related Articles

  • Cadmium-Induced Apoptosis in Rat Kidney Epithelial Cells Involves Decrease in Nuclear Factor-Kappa B Activity. Jianxun Xie; Shaikh, Zahir A. // Toxicological Sciences;May2006, Vol. 91 Issue 1, p299 

    Renal epithelial cells undergo apoptosis upon exposure to cadmium (Cd). Transcription factors, such as nuclear factor-kappa B (NF-κB), mediate the expression of a number of genes involved in apoptosis. The present study was designed to examine the involvement of this transcription factor in...

  • Pyrrolidine Dithiocarbamate Attenuates Nuclear Factor-κB Activation, Cyclooxygenase-2 Expression and Prostaglandin E2 Production in Human Endometriotic Epithelial Cells. Zhang, Jing-jing; Xu, Zhi-ming; Chang, Hong; Zhang, Chun-mei; Dai, Hong-ying; Ji, Xin-qiang; Li, Chao; Wang, Xu-fu // Gynecologic & Obstetric Investigation;Oct2011, Vol. 72 Issue 3, p163 

    Background: The nuclear factor-κB (NF-κB) pathway activates many of the target genes that are critical to the initiation and establishment of endometriosis. We sought to examine the potential application of pyrrolidine dithiocarbamate (PDTC), a potent NF-κB inhibitor, in the treatment...

  • The Many Roles of RANKL-RANK Signaling in Bone, Breast and Cancer. Schramek, Daniel; Penninger, Josef M. // IBMS BoneKEy;May2011, Vol. 8 Issue 5, p237 

    Receptor activator of nuclear factor-κB ligand (RANKL), its signaling receptor RANK, and its natural decoy receptor OPG are members of the tumor necrosis factor (TNF) and TNF receptor superfamily and are best known for their essential role in controlling osteoclastogenesis. RANKL in bone has...

  • TRAF2 is an NF-κB-activating oncogene in epithelial cancers. Shen, R R; Zhou, A Y; Kim, E; O'Connell, J T; Hagerstrand, D; Beroukhim, R; Hahn, W C // Oncogene;1/8/2015, Vol. 34 Issue 2, p209 

    Aberrant nuclear factor (NF)-κB activation is frequently observed in human cancers. Genome characterization efforts have identified genetic alterations in multiple components of the NF-κB pathway, some of which have been shown to be essential for cancer initiation and tumor maintenance....

  • Peoniflorin suppresses tumor necrosis factor-α induced chemokine production in human dermal microvascular endothelial cells by blocking nuclear factor-κB and ERK pathway. Chen, Tao; Guo, Zai-pei; Jiao, Xiao-yan; Jia, Rui-zhen; Zhang, Yu-hong; Li, Jing-yi; Huang, Xu-lei; Liu, Hong-jie // Archives of Dermatological Research;Jul2011, Vol. 303 Issue 5, p351 

    Peoniflorin (PF) extracted from the root of Paeonia lactiflora pall displays anti-inflammation and antioxidant properties in several animal models. Chemokines are vital for directing the movement of circulating leukocytes to the sites of inflammation and are involved in the pathogenesis of...

  • 6-Mercaptopurine reduces cytokine and Muc5ac expression involving inhibition of NFκB activation in airway epithelial cells. Kurakula, Kondababu; Hamers, Anouk A.; van Loenen, Pieter; de Vries, Carlie J. M. // Respiratory Research;Jul2015, Vol. 16 Issue 1, p1 

    Background: Mucus hypersecretion and excessive cytokine synthesis is associated with many of the pathologic features of chronic airway diseases such as asthma. 6-Mercaptopurine (6-MP) is an immunosuppressive drug that is widely used in several inflammatory disorders. Although 6-MP has been used...

  • Nicotine Reduces TNF-α Expression Through a α7 nAChR/MyD88/NF-κB Pathway in HBE16 Airway Epithelial Cells. Li, Qi; Zhou, Xiang-Dong; Kolosov, Victor P.; Perelman, Juliy M. // Cellular Physiology & Biochemistry (Karger AG);2011, Vol. 27 Issue 5, p605 

    Aims: To explore the signaling mechanism associated with the inhibitory effect of nicotine on tumor necrosis factor (TNF)- α expression in human airway epithelial cells. Methods: HBE16 airway epithelial cells were cultured and incubated with either nicotine or cigarette smoke extract (CE)....

  • An antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathway. Nakajima, Akihito; Komazawa-Sakon, Sachiko; Takekawa, Mutsuhiro; Sasazuki, Tomonari; Wen-Chen Yeh; Yagita, Hideo; Okumura, Ko; Nakano, Hiroyasu // EMBO Journal;11/29/2006, Vol. 25 Issue 23, p5549 

    Inhibition of NF-κB activation increases susceptibility to tumor necrosis factor (TNF)α-induced cell death, concurrent with caspases and prolonged c-Jun N-terminal kinase (JNK) activation, and reactive oxygen species (ROS) accumulation. However, the detailed mechanisms are unclear. Here we...

  • Understanding NEMO. Smallridge, Rachel // Nature Reviews Molecular Cell Biology;Jun2006, Vol. 7 Issue 6, p384 

    Presents two studies on NF-κB essential modulator (NEMO). Role of NEMO in NF-κB activation; Association of tumour-necrosis-factor receptor-1 with NEMO; Significance of NEMO for IκB kinase activation; Observations on receptor-interacting protein-1 in NEMO-deficient cells.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics