TITLE

8q24 Cancer Risk Allele Associated with Major Metastatic Risk in Inflammatory Breast Cancer

AUTHOR(S)
Bertucci, Françis; Lagarde, Arnaud; Ferrari, Anthony; Finetti, Pascal; Charafe-Jauffret, Emmanuelle; Laere, Steven Van; Adelaide, José; Viens, Patrice; Thomas, Gilles; Birnbaum, Daniel; Olschwang, Sylviane
PUB. DATE
May 2012
SOURCE
PLoS ONE;May2012, Vol. 7 Issue 5, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Association studies have identified low penetrance alleles that participate to the risk of cancer development. The 8q24 chromosomal region contains several such loci involved in various cancers that have been recently studied for their propensity to influence the clinical outcome of prostate cancer. We investigated here two 8q24 breast and colon cancer risk alleles in the close vicinity of the MYC gene for their role in the occurrence of distant metastases. Methodology/Principal findings: A retrospective series of 449 patients affected with breast or colon adenocarcinoma was genotyped for the rs13281615 and/or rs6983267 SNPs. Statistical analyses were done using the survival package v2.30 in the R software v2.9.1. The two SNPs did not influence the development of distant metastases of colon cancer; rs6983267 showed a mild effect on breast cancer. However, this effect was greatly emphasized when considering inflammatory breast cancer (IBC) solely. Replicated on a larger and independent series of IBC the contribution of the genotype to the metastatic risk of IBC was found an independent predictor of outcome (p = 2e-4; OR 8.3, CI95:2.6-33). Conclusions/Significance: Our study shows first that the monitoring of this specific germline variation may add a substantial tool for IBC prognostication, an aggressive disease that evolves towards distant metastases much more frequently than non-IBC and for which no reliable prognostic factor is available in medical practice. Second, it more generally suggests that risk alleles, while associated with low susceptibility, could correlate with a high risk of metastasis.
ACCESSION #
79461314

 

Related Articles

  • Genome-Wide Association Study of Breast Cancer in the Japanese Population. Low, Siew-Kee; Takahashi, Atsushi; Ashikawa, Kyota; Inazawa, Johji; Miki, Yoshio; Kubo, Michiaki; Nakamura, Yusuke; Katagiri, Toyomasa // PLoS ONE;Oct2013, Vol. 8 Issue 10, p1 

    Breast cancer is the most common malignancy among women in worldwide including Japan. Several studies have identified common genetic variants to be associated with the risk of breast cancer. Due to the complex linkage disequilibrium structure and various environmental exposures in different...

  • Recurrent mutations of BRCA1, BRCA2 and PALB2 in the population of breast and ovarian cancer patients in Southern Poland. Wojcik, P.; Jasiowka, M.; Strycharz, E.; Sobol, M.; Hodorowicz-Zaniewska, D.; Skotnicki, P.; Byrski, T.; Blecharz, P.; Marczyk, E.; Cedrych, I.; Jakubowicz, J.; Lubiński, J.; Sopik, V.; Narod, S.; Pierzchalski, P. // Hereditary Cancer in Clinical Practice;2/3/2016, Vol. 14, p1 

    Background: Mutations in the BRCA1, BRCA2 and PALB2 genes are well-established risk factors for the development of breast and/or ovarian cancer. The frequency and spectrum of mutations in these genes has not yet been examined in the population of Southern Poland. Methods: We examined the entire...

  • Validation of a Breast Cancer Risk Prediction Model Developed for Black Women. Boggs, Deborah A.; Rosenberg, Lynn; Pencina, Michael J.; Adams-Campbell, Lucile L.; Palm, Julie R. // JNCI: Journal of the National Cancer Institute;3/6/2013, Vol. 105 Issue 5, p361 

    Background A breast cancer risk prediction model for black women, developed from data in the Women's Contraceptive and Reproductive Experiences (CARE) study, has been validated in women aged 50 years or older but not among younger women or for specific breast cancer subtypes. Methods We assessed...

  • An analysis of selected health behaviours of women as breast cancer risk factors. Kachaniuk, Hanna; Stanisławek, Andrzej; Bartoszek, Agnieszka; Kocka, Katarzyna; Szadowska-Szlachetka, Zdzisława; Charzyńska-Gula, Marianna // Menopausal Review / Przeglad Menopauzalny;2013, Vol. 12 Issue 6, p453 

    Introduction: Health behaviours are the most important factor conditioning human health in approx. 50%. Also in cancer prevention the behaviours which women can have impact an on are crucial. Aim of the study: An attempt to diagnose selected health behaviours as breast cancer risk factors and to...

  • Association of reproductive factors with the incidence of breast cancer in Gulf Cooperation Council countries. Ravichandran, K.; Al-Zahrani, A. S. // Eastern Mediterranean Health Journal;mai/jun2009, Vol. 15 Issue 3, p612 

    This article presents the incidence of female breast cancer in the Gulf Cooperation Council (GCC) countries and reviews the data in relation to established reproductive factors. Overall 4480 female breast cancer cases were diagnosed during 1998-2002 among GCC country nationals. Breast cancer was...

  • A novel recurrent CHEK2 Y390C mutation identified in high-risk Chinese breast cancer patients impairs its activity and is associated with increased breast cancer risk. Wang, N; Ding, H; Liu, C; Li, X; Wei, L; Yu, J; Liu, M; Ying, M; Gao, W; Jiang, H; Wang, Y // Oncogene;10/1/2015, Vol. 34 Issue 40, p5198 

    Certain predisposition factors such as BRCA1/2 and CHEK2 mutations cause familial breast cancers that occur early. In China, breast cancers are diagnosed at relatively younger age, and higher percentage of patients are diagnosed before 40 years, than that in Caucasians. However, the prevalence...

  • Prevalence and risk factors of bone metastasis and skeletal related events in patients with primary breast cancer in Japan. Yamashiro, Hiroyasu; Takada, Masahiro; Nakatani, Eiji; Imai, Shiro; Yamauchi, Akira; Tsuyuki, Shigeru; Matsutani, Yasuo; Sakata, Shingo; Wada, Yasuo; Okamura, Ryuji; Harada, Tomika; Tanaka, Fumie; Moriguchi, Yoshio; Kato, Hironori; Higashide, Shunichi; Kan, Norimichi; Yoshibayashi, Hiroshi; Suwa, Hirofumi; Okino, Takashi; Nakayama, Ichiro // International Journal of Clinical Oncology;Oct2014, Vol. 19 Issue 5, p852 

    Background: Bone metastasis (BM) is important for studying systemic spread of breast cancer. It often causes skeletal-related events (SREs) that worsen quality of life. We investigated the prevalence and risk factors for BM and SRE using a dataset from the Breast Oncology Research Network (BORN)...

  • Association of HADHA expression with the risk of breast cancer: targeted subset analysis and metaanalysis of microarray data.  // BMC Research Notes;2012, Vol. 5 Issue 1, p25 

    The article offers information on a study conducted by the authors related to association of hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase alpha subunit (HADHA) with breast cancer risk. They examined whether genes related to lipid metabolism and fatty acid are...

  • METAKRON BÄ°LATERAL MEME KANSERLÄ° HASTALARIMIZIN KLÄ°NÄ°K DEÄžERLENDÄ°RÄ°LMESÄ°. Menteş, Öner; Akın, Murat; Öztürk, Erkan; Balkan, Müjdat; Tufan, Turgut // Meme Sagligi Dergisi / Journal of Breast Health;2008, Vol. 4 Issue 1, p38 

    OBJECTIVE: The incidence of bilateral breast cancer has shown the range from 2% to as high 11%. Breast cancer patients should follow up against the other side breast cancer risk. METHODS: Medical records of patients who were treated for breast cancer were reviewed during a 5 years period of...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics