Antenatal antibiotic exposure in preterm infants with necrotizing enterocolitis

Weintraub, A S; Ferrara, L; Deluca, L; Moshier, E; Green, R S; Oakman, E; Lee, M-J; Rand, L
September 2012
Journal of Perinatology;Sep2012, Vol. 32 Issue 9, p705
Academic Journal
Objective:To determine whether an association exists between antenatal antibiotic exposure and incidence of necrotizing enterocolitis (NEC) in low birth weight infants.Study Design:A retrospective case-control study was performed on all infants with a diagnosis of NEC born at our institition between 1988 and 2006. Medical histories of all infants with a diagnosis of NEC Bell's stage IIA and matched controls without NEC were reviewed. Maternal and neonatal characteristics were compared using the Mantel-Haenszel chi-square procedure, and logistic regression models were constructed to account for confounding.Result:Clinical data for 97 matched pairs were analyzed. The adjusted odds ratio (OR) for antenatal exposure to ampicillin was significantly greater for infants who developed NEC (OR 2.3, 95% confidence interval 1.1, 4.8, P=0.003) than for control infants.Conclusion:Infants who developed NEC were more likely to have a history of in utero exposure to ampicillin in the immediate antepartum period than infants who did not develop NEC.


Related Articles

  • Risk of preterm delivery in non-diabetic women with polycystic ovarian syndrome. Yamamoto, M; Feigenbaum, S L; Crites, Y; Escobar, G J; Yang, J; Ferrara, A; Lo, J C // Journal of Perinatology;Oct2012, Vol. 32 Issue 10, p770 

    Objective:To examine the risk and etiology of preterm delivery in women with polycystic ovary syndrome (PCOS).Study Design:Retrospective cohort study comparing preterm delivery rate among non-diabetic PCOS and non-PCOS women with singleton pregnancy. Multivariable logistic regression was used to...

  • Severe perineal laceration during operative vaginal delivery: the impact of occiput posterior position. Hirsch, E; Elue, R; Wagner, A; Nelson, K; Silver, R K; Zhou, Y; Adams, M G // Journal of Perinatology;Dec2014, Vol. 34 Issue 12, p898 

    Objective:To identify risk factors for severe (third/fourth degree) perineal laceration with operative vaginal delivery (OVD, forceps or vacuum).Study Design:Case-control study comparing singleton OVDs with or without severe laceration (n=138).Result:In multivariable analyses, severe perineal...

  • Coagulase-negative staphylococcus sepsis in preterm infants and long-term neurodevelopmental outcome. Alshaikh, B; Yee, W; Lodha, A; Henderson, E; Yusuf, K; Sauve, R // Journal of Perinatology;Feb2014, Vol. 34 Issue 2, p125 

    Objective:The objective of this study was to examine the impact of Coagulase-negative staphylococcus (CoNS) sepsis in preterm infants on the neurodevelopmental outcomes at 30 to 42 months corrected age (CA).Study Design:This is a retrospective cohort study. All preterm infants born at <29 weeks...

  • The association of congenital heart disease with necrotizing enterocolitis in preterm infants: a birth cohort study. Motta, C; Scott, W; Mahony, L; Koch, J; Wyckoff, M; Reisch, J; Burchfield, P J; Brion, L P // Journal of Perinatology;Nov2015, Vol. 35 Issue 11, p949 

    Objective:To test the hypothesis that congenital heart disease (CHD) in preterm infants with severe CHD (cyanotic or left-sided obstructive lesions, or congestive heart failure) is independently associated with necrotizing enterocolitis (NEC, stage II or greater).Study design:Single-institution...

  • Preterm Birth Among American Indian/Alaskan Natives in Washington and Montana: Comparison with Non-Hispanic Whites. Hwang, Melody; Shrestha, Archana; Yazzie, Sheldwin; Jackson, Michael L. // Maternal & Child Health Journal;Dec2013, Vol. 17 Issue 10, p1908 

    Preterm birth is the single most important cause of perinatal mortality in North America. Given that American Indians/Alaskan Natives (AI/ANs) in the United States continue to have adverse birth outcomes, the purpose of this study is to compare the risk of preterm birth among AI/AN mothers to...

  • Preterm Birth in the United States: The Impact of Stressful Life Events Prior to Conception and Maternal Age. Witt, Whitney P.; Cheng, Erika R.; Wisk, Lauren E.; Litzelman, Kristin; Chatterjee, Debanjana; Mandell, Kara; Wakeel, Fathima // American Journal of Public Health;Feb2014 Supplement, Vol. 104 Issue S1, pS73 

    Objectives. We determined whether and to what extent a woman's exposure to stressful life events prior to conception (PSLEs) was associated with preterm birth and whether maternal age modified this relationship. Methods. We examined 9350 mothers and infants participating in the first wave of the...

  • Indoor Smoke Exposure and Risk of Anthracosis. Qorbani, Mostafa; Yunesian, Masud; Baradaran, Hamid Reza // Iranian Journal of Medical Sciences;Nov2014, Vol. 39 Issue 6, p571 

    The association between indoor smoke exposure due to traditional baking (baking homemade bread) and anthracosis has rarely been investigated. The aim of the present study is to quantify such association among the Iranian population. A hospital based case-control study was carried out on 83...

  • The association of inadequate mid-pregnancy weight gain and preterm birth in twin pregnancies. Pettit, K E; Lacoursiere, D Y; Schrimmer, D B; Alblewi, H; Moore, T R; Ramos, G A // Journal of Perinatology;Feb2015, Vol. 35 Issue 2, p85 

    Objective:To determine whether inadequate gestational weight gain in the second trimester in twin pregnancies is associated with an increased risk of preterm birth (PTB) at <32 weeks.Study Design:Retrospective cohort study including 489 twin pregnancies delivered between 2001 and 2013. Rates of...

  • Leptin and leptin receptor polymorphisms and recurrent pregnancy loss. Chin, J R; Heuser, C C; Eller, A G; Branch, D W; Nelson, L T; Silver, R M // Journal of Perinatology;Aug2013, Vol. 33 Issue 8, p589 

    Objective:Leptin signaling is important in the establishment of pregnancy. We sought to determine if single nucleotide polymorphisms (SNPs) in the leptin and leptin receptor genes are associated with idiopathic recurrent pregnancy loss (RPL).Study Design:We conducted a case-control study with...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics