TITLE

Prevalence of Hepatitis B Virus Infection in Healthcare Workers of a Tertiary Care Centre in India and Their Vaccination Status

AUTHOR(S)
Singhal, Varsha; Bora, Dhrubajyoti; Singh, Sarman
PUB. DATE
April 2011
SOURCE
Journal of Vaccines & Vaccination;2011, Vol. 2 Issue 2, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Healthcare Workers have a high risk of occupational exposure to many blood-borne diseases including HIV, Hepatitis B, and Hepatitis C viral infections. Of these Hepatitis B is not only the most transmissible infection, but also the only one that is preventable by vaccination. Objectives: This study was conducted to estimate the prevalence of Hepatitis B virus infection in healthcare workers (HCWs) employed at the All India Institute of Medical Sciences, New Delhi and to measure protective levels of anti-HBs antibody titre in them. Methods: A total of 446 Health care workers are grouped in 7 categories according to nature of their work. After ethical clearance and written consent, all health care workers were explained about the objective of the study and were asked to fill a standard questionnaire regarding their personal health information. Their blood samples were tested by Enzyme Linked Immunosorbent assay (ELISA) for Hepatitis B surface antigen and anti-HBs antibody titres. Results and Interpretation: Out of 446 HCWs, 252 (56.5%) were vaccinated. In 199 (79%) of those vaccinated persons, protective levels (>10 IU/ mL) of anti-Hepatitis B surface antigen (anti-HBs) were seen. However, protective levels were also detected in 36 (19.35%) of 186 unvaccinated HCW as natural immunity (p<0.001). The antibody levels were significantly lower in those who were vaccinated more than 5 years ago than those who were vaccinated in last 5 years. Only 2 (0.4%) HCWs were found to be HBsAg positive. A significant number (41.7%) of HCW are unvaccinated even at this apex health care centre suggesting a need for proactive implementation of HBV vaccination programme.
ACCESSION #
79344066

 

Related Articles

  • Identification of occult hepatitis B virus (HBV) infection and viral antigens in healthcare workers who presented low to moderate levels of anti-HBs after HBV vaccination. Borzooy, Zohreh; Jazayeri, Seyed Mohammad; Mirshafiey, Abbass; Khamseh, Azam; Mahmoudie, Masoud Karkhaneh; Azimzadeh, Pedram; Geravand, Babak; Boroumand, Mohammad Ali; Afshar, Mina; Poortahmasebi, Vahdat; Hosseini, Mostafa; Streinu-Cercel, Adrian // Germs;Dec2015, Vol. 5 Issue 4, p134 

    Background Worldwide, healthcare workers (HCWs) show different levels of response to hepatitis B virus (HBV) vaccine. One of the factors associated with vaccine unresponsiveness may be the existence of current or past HBV infection. Regardless of the presence of HBsAg (overt infection), occult...

  • Occupational transmission and prevention of HBV among health care workers in a tertiary care center. Mantri, Ravikumar; Suman, Febe Ranjitha; Krishnamoorthy, R.; Panicker, Vinodkumar // BMC Infectious Diseases;2012 Supplement, Vol. 12 Issue Supplment 1, p1 

    The article presents a study on the exposure of health care workers of tertiary care centers in India to hepatitis B virus (HBV). The authors investigates the effect of vaccination program among the health care workers in helping prevent HBV tranmisstion among health workers. They state that...

  • Recombinant Hepatitis B Vaccine: A Review of its Immunogenicity and Protective Efficacy Against Hepatitis B. Adkins, J.C.; Wagstaff, A.J. // BioDrugs;1998, Vol. 10 Issue 2, p137 

    Recombinant hepatitis B vaccine Engerix B [Hep-B(Eng)] is a noninfectious subunit hepatitis B viral vaccine indicated for the active immunisation of adults, children and infants against hepatitis B virus infection. It contains hepatitis B surface antigen (HBsAg) which is produced by the yeast...

  • Hepatitis B Vaccine.  // Annals of Internal Medicine;Jan84, Vol. 100 Issue 1, p149 

    Announces the availability of a licensed vaccine for the prevention of hepatitis B virus infection in the U.S. Annual incidence; Duration of protective antibody levels; Response of immunosuppressed patients to vaccine.

  • Many High-risk Americans Don't Get Hepatitis B Vaccine.  // Bioscience Technology;Feb2012, Vol. 36 Issue 2, p11 

    The article reports that missed opportunities to administer the hepatitis B vaccine continue to be a reason why thousands of Americans contract the virus for the infectious liver disease annually, according to a study by Brown University researchers published in the journal "Infection."

  • Low coverage of hepatitis B vaccine and determinants among health professionals working in Amhara regional state hospitals, Ethiopia. Feleke, Berhanu Elfu // Journal of Public Health in Africa;2016, Vol. 7 Issue 2, p50 

    More than two billion people have been infected with hepatitis B virus (HBV), 360 million have chronic infection and 600,000 die each year from HBV-related liver disease or hepatocellular carcinoma. Each year more than 66,000 health professionals are infected by hepatitis b virus and vaccination...

  • Understanding correlates of hepatitis B virus vaccination in men who have sex with men: what have we learned? Yee, L.J.; Rhodes, S.D. // Sexually Transmitted Infections;Oct2002, Vol. 78 Issue 5, p374 

    Objectives: Hepatitis B infection (HBV) is prevalent among men who have sex with men (MSM) and may lead to significant morbidity and death. Although an effective vaccine exists vaccination rates among MSM are Iow. We conducted a systematic review to synthesise the various findings from empirical...

  • New formulation of hepatitis B vaccine.  // American Family Physician;11/15/1993, Vol. 48 Issue 7, p1314 

    Reports that the United States Food and Drug Administration has licensed a new formulation of the recombinant hepatitis B vaccine intended specifically for infants.

  • Extent of hepatitis B immunisation among medical and dental students. Sivarajasingam, V.; Laszlo, J. // BMJ: British Medical Journal (International Edition);7/22/95, Vol. 311 Issue 6999, p231 

    Discusses the extent of hepatitis B immunization among medical and dental students in Great Britain. Ratio of hepatitis B patients in total earth population; Percentage of medical and dental students who are unaware of recommended antibody titre; Responsibility of students to ensure adequate...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics