TITLE

Long-Term Post-Treatment MR and PET/CT Imaging in Prostate Cancer Patients in Complete Remission after Curative Radiotherapy with or without Androgen Deprivation: The Image of Cure

AUTHOR(S)
Miralbell, Raymond; Vees, Hansjörg; Ratib, Osman; Wissmeyer, Michael; Steiner, Charles; Seimbille, Yann; Khan, Haleem G.; Buchegger, Franz
PUB. DATE
July 2011
SOURCE
Journal of Nuclear Medicine & Radiation Therapy;2011, Vol. 2 Issue 3, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Purpose: To investigate the risk of false positive MRI and 18F-Fluorocholine (FCH) or 11Cacetate (AC) PET/ CT in prostate cancer patients with long term biochemical and clinical remission after curative radiation therapy (RT). Methods and Materials: Twenty patients underwent MRI studies including T2-weighted, diffusion weighted, dynamic contrast-enhanced, and spectroscopic imaging. Nine of these patients were selected to have FCH and 10 AC PET/CT studies. Results: MR spectroscopy suggested positive or equivocal results in 16/20 patients. However, the combined interpretation of all MRI sequences dropped the rate of suspicious or equivocal studies to 8/20. All but one patient underwent also PET/CT and early PET frames showed suspicious or equivocal local images in 15/19 patients (8/10 with AC, 7/9 with FCH). However, a combined evaluation of early and late PET frames was judged equivocal in only 1 patient. Conclusions: Multimodal MRI, early single FCH or AC PET frames of the prostate after curative RT may not be accurate enough to differentiate remission from early recurrence. Multiple-phase evaluation of PET images, however, may reduce significantly the risk of reporting equivocal or false positive results.
ACCESSION #
79344023

 

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