The yin and yang of CD1d recognition

Adams, Erin J; Luoma, Adrienne M
September 2012
Nature Immunology;Sep2012, Vol. 13 Issue 9, p814
Academic Journal
No abstract available.


Related Articles

  • Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor. Patel, Onisha; Pellicci, Daniel G; Gras, Stephanie; Sandoval-Romero, Maria L; Uldrich, Adam P; Mallevaey, Thierry; Clarke, Andrew J; Le Nours, Jérôme; Theodossis, Alex; Cardell, Susanna L; Gapin, Laurent; Godfrey, Dale I; Rossjohn, Jamie // Nature Immunology;Sep2012, Vol. 13 Issue 9, p857 

    Natural killer T cells (NKT cells) are divided into type I and type II subsets on the basis of differences in their T cell antigen receptor (TCR) repertoire and CD1d-antigen specificity. Although the mode by which type I NKT cell TCRs recognize CD1d-antigen has been established, how type II NKT...

  • The TCR's sensitivity to self peptide-MHC dictates the ability of naive CD8+ T cells to respond to foreign antigens. Fulton, Ross B; Hamilton, Sara E; Xing, Yan; Best, J Adam; Goldrath, Ananda W; Hogquist, Kristin A; Jameson, Stephen C // Nature Immunology;Jan2015, Vol. 16 Issue 1, p107 

    The strength with which complexes of self peptide and major histocompatibility complex (MHC) proteins are recognized by the T cell antigen receptor (TCR) dictates the homeostasis of naive CD8+ T cells, but its effect on reactivity to foreign antigens is controversial. As expression of the...

  • Type II natural killer T cells use features of both innate-like and conventional T cells to recognize sulfatide self antigens. Girardi, Enrico; Maricic, Igor; Wang, Jing; Mac, Thien-Thi; Iyer, Pooja; Kumar, Vipin; Zajonc, Dirk M // Nature Immunology;Sep2012, Vol. 13 Issue 9, p851 

    Glycolipids presented by the major histocompatibility complex (MHC) class I homolog CD1d are recognized by natural killer T cells (NKT cells) characterized by either a semi-invariant T cell antigen receptor (TCR) repertoire (type I NKT cells or iNKT cells) or a relatively variable TCR repertoire...

  • Species Specific Differences of CD1d Oligomer Loading In Vitro. Paletta, Daniel; Fichtner, Alina Suzann; Starick, Lisa; Porcelli, Steven A.; Savage, Paul B.; Herrmann, Thomas // PLoS ONE;11/24/2015, Vol. 10 Issue 11, p1 

    CD1d molecules are MHC class I-like molecules that present glycolipids to iNKT cells. The highly conserved interaction between CD1d:α-Galactosylceramide (αGC) complexes and the iNKT TCR not only defines this population of αβ T cells but can also be used for its direct identification....

  • Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells. Vavassori, Stefano; Kumar, Anil; Wan, Gan Siok; Ramanjaneyulu, Gundimeda S; Cavallari, Marco; El Daker, Sary; Beddoe, Travis; Theodossis, Alex; Williams, Neal K; Gostick, Emma; Price, David A; Soudamini, Dinish U; Voon, Kong Kien; Olivo, Malini; Rossjohn, Jamie; Mori, Lucia; De Libero, Gennaro // Nature Immunology;Sep2013, Vol. 14 Issue 9, p908 

    Human T cells that express a T cell antigen receptor (TCR) containing γ-chain variable region 9 and δ-chain variable region 2 (Vγ9Vδ2) recognize phosphorylated prenyl metabolites as antigens in the presence of antigen-presenting cells but independently of major histocompatibility...

  • Inhibitory NK-cell receptors on T cells: witness of the past, actors of the future. Vivier, Eric; Anfossi, Nicolas // Nature Reviews Immunology;Mar2004, Vol. 4 Issue 3, p190 

    Inhibitory MHC class I receptors were initially described on natural killer (NK) cells, where they participate in inducing NK-cell self-tolerance. Inhibitory NK-cell receptors (iNKRs) can also be expressed by diverse T-cell subsets, including NKT cells, CD8+ αβ -T-cell receptor...

  • NK cells and their receptors. Yokoyama, Wayne M.; Riley, Joan K. // Reproductive BioMedicine Online (Reproductive Healthcare Limited;Feb2008, Vol. 16 Issue 2, p173 

    Despite early reports that natural killer (NK) cells are non-specific or have non-major histocompability complex (MHC)- restricted killing, it is now clear that NK cells express a panoply of receptors with defined specificity for ligands expressed on their cellular targets. The roles of these...

  • Having it both ways: MHC recognition in cis and trans. Leibson, Paul J.; Pease, Larry R. // Nature Immunology;Mar2004, Vol. 5 Issue 3, p237 

    Reports on a study which suggests that engagement of major histocompatibility complex (MHC) class I by inhibitory receptors may not always deliver an inhibitory signal. Density of inhibitory receptors on natural killer cells; Alternative mechanism for the modulation of the receptors.

  • Casting new light on the TCR. Hayday, Adrian; Tigelaar, Robert // Nature Immunology;Mar2012, Vol. 13 Issue 3, p209 

    No abstract available.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics