Epitope selection for multipeptide proteins: the case of RNA polymerase IV and V

Canche Moo, Leydi; Arroyo Herrera, Analy; Rodriguez-Zapata, Luis; Suarez, Victor; Castano, Enrique
October 2012
Biologia;Oct2012, Vol. 67 Issue 5, p845
Academic Journal
No abstract available.


Related Articles

  • An atypical RNA polymerase involved in RNA silencing shares small subunits with RNA polymerase II. Linfeng Huang; Jones, Alexandra M. E.; Searle, Iain; Patel, Kanu; Vogler, Hannes; Hubner, Nina C.; Baulcombe, David C. // Nature Structural & Molecular Biology;Jan2009, Vol. 16 Issue 1, p91 

    Genetic evidence indicates that plant-specific homologs of DNA-dependent RNA polymerase (Pol) II large subunits form Pol IV and Pol V complexes involved in small interfering RNA production and RNA-directed DNA methylation. Here we describe evidence that Pol V contains subunits shared with Pol...

  • Multisubunit RNA polymerases IV and V: purveyors of non-coding RNA for plant gene silencing. Haag, Jeremy R.; Pikaard, Craig S. // Nature Reviews Molecular Cell Biology;Aug2011, Vol. 12 Issue 8, p483 

    In all eukaryotes, nuclear DNA-dependent RNA polymerases I, II and III synthesize the myriad RNAs that are essential for life. Remarkably, plants have evolved two additional multisubunit RNA polymerases, RNA polymerases IV and V, which orchestrate non-coding RNA-mediated gene silencing processes...

  • A highly conserved WDYPKCDRA epitope in the RNA directed RNA polymerase of human coronaviruses can be used as epitope-based universal vaccine design. Sharmin, Refat; Islam, Abul Bashar // BMC Bioinformatics;2014, Vol. 15 Issue 1, p1 

    Background Coronaviruses are the diverse group of RNA virus. From 1960, six strains of human coronaviruses have emerged that includes SARS-CoV and the recent infection by deadly MERS-CoV which is now going to cause another outbreak. Prevention of these viruses is urgent and a universal vaccine...

  • SIVsm Tat, Rev, and Nef1: functional characteristics of r-GV internalization on isotypes, cytokines, and intracellular degradation. Sremac, Marinko; Stuart, Elizabeth S. // BMC Biotechnology;2010, Vol. 10, p54 

    Background: Recombinant gas vesicles (r-GV) from Halobacterium sp. strain SD109 expressing cassettes with different SIVsm inserts, have potential utility as an effective antigen display system for immunogen testing in vivo and for initial epitope assessments in vitro. Previous mouse model...

  • The Goodpasture antigen is expressed in the human thymus. Wong, Dichelle; Phelps, Richard G.; Turner, A. Neil // Kidney International;Nov2001, Vol. 60 Issue 5, p1777 

    The Goodpasture antigen is expressed in the human thymus. Background. Autoimmunity to kidney antigens causes membranous nephropathy and Goodpasture's disease and very likely is pivotal in many other glomerular diseases. We investigated the potential for central tolerance to the...

  • A Computational Approach for Designing a Universal Epitope-Based Peptide Vaccine Against Nipah Virus. Ali, Mohammad; Morshed, Mohammed; Hassan, Faizule // Interdisciplinary Sciences: Computational Life Sciences;Jun2015, Vol. 7 Issue 2, p177 

    Nipah virus (NiV) is highly pathogenic single-stranded negative sense RNA virus. It can cause severe encephalitis and respiratory disease in humans. In addition, NiV infects a large range of host including mammals. As a result of its higher zoonotic potential and pathogenicity for human, it has...

  • The Insertion of Fluorescent Proteins in a Variable Region of Respiratory Syncytial Virus L Polymerase Results in Fluorescent and Functional Enzymes But with Reduced Activities. Fix, Jenna; Galloux, Marie; Blondot, Marie-Lise; Eléouët, Jean-François // Open Virology Journal;2011, Vol. 5, p103 

    The respiratory syncytial virus (RSV) Large protein L is the catalytic subunit of the RNA-dependent RNA polymerase complex. Currently, no structural information is available for RSV L. Sequence alignments of L protein from human and bovine strains of RSV revealed the existence of two variable...

  • polymerase.  // Taber's Cyclopedic Medical Dictionary;2005, p1726 

    A definition of the term "polymerase" is presented. It refers to enzymes that catalyzes polymerization of nucleotides to form DNA molecules before cell division. In case of RNA molecules polymerase catalyzes polymerization of nucleotides before protein synthesis.

  • RNA-directed DNA methylation: an epigenetic pathway of increasing complexity. Matzke, Marjori A.; Mosher, Rebecca A. // Nature Reviews Genetics;Jun2014, Vol. 15 Issue 6, p394 

    RNA-directed DNA methylation (RdDM) is the major small RNA-mediated epigenetic pathway in plants. RdDM requires a specialized transcriptional machinery that comprises two plant-specific RNA polymerases - Pol IV and Pol V - and a growing number of accessory proteins, the functions of which in the...

  • SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation. Johnson, Lianna M.; Du, Jiamu; Hale, Christopher J.; Bischof, Sylvain; Feng, Suhua; Chodavarapu, Ramakrishna K.; Zhong, Xuehua; Marson, Giuseppe; Pellegrini, Matteo; Segal, David J.; Patel, Dinshaw J.; Jacobsen, Steven E. // Nature;3/6/2014, Vol. 507 Issue 7490, p124 

    RNA-directed DNA methylation in Arabidopsis thaliana depends on the upstream synthesis of 24-nucleotide small interfering RNAs (siRNAs) by RNA POLYMERASE IV (Pol IV) and downstream synthesis of non-coding transcripts by Pol V. Pol V transcripts are thought to interact with siRNAs which then...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics