Usefulness of suPAR as a biological marker in patients with systemic inflammation or infection: a systematic review

Backes, Yara; Sluijs, Koenraad; Mackie, David; Tacke, Frank; Koch, Alexander; Tenhunen, Jyrki; Schultz, Marcus
September 2012
Intensive Care Medicine;Sep2012, Vol. 38 Issue 9, p1418
Academic Journal
Purpose: Systemic levels of soluble urokinase-type plasminogen activator receptor (suPAR) positively correlate with the activation level of the immune system. We reviewed the usefulness of systemic levels of suPAR in the care of critically ill patients with sepsis, SIRS, and bacteremia, focusing on its diagnostic and prognostic value. Methods: A PubMed search on suPAR was conducted, including manual cross-referencing. The list of papers was narrowed to original studies of critically ill patients. Ten papers on original studies of critically ill patients were identified that report on suPAR in sepsis, SIRS, or bacteremia. Results: Systematic levels of suPAR have little diagnostic value in critically ill patients with sepsis, SIRS, or bacteremia. Systemic levels of suPAR, however, have superior prognostic power over other commonly used biological markers in these patients. Mortality prediction by other biological markers or severity-of-disease classification system scores improves when combining them with suPAR. Systemic levels of suPAR correlate positively with markers of organ dysfunction and severity-of-disease classification system scores. Finally, systemic levels of suPAR remain elevated for prolonged periods after admission and only tend to decline after several weeks. Notably, the type of assay used to measure suPAR as well as the age of the patients and underlying disease affect systemic levels of suPAR. Conclusions: The diagnostic value of suPAR is low in patients with sepsis. Systemic levels of suPAR have prognostic value, and may add to prognostication of patients with sepsis or SIRS complementing severity-of-disease classification systems and other biological markers.


Related Articles

  • suPAR as a prognostic biomarker in sepsis.  // BMC Medicine;2012, Vol. 10 Issue 1, p2 

    The article offers information on a study conducted on soluble urokinase-type plasminogen activator receptor (suPAR), which can be used as a prognostic biomarker in sepsis. It states that suPAR expression is increased on peripheral blood mononuclear cells as on granulocytes and monocytes. It...

  • Is continuous infusion ceftriaxone better than once-a-day dosing in intensive care? A randomized controlled pilot study. Jason A. Roberts; Rob Boots; Claire M. Rickard; Peter Thomas; Jo Quinn; Darren M. Roberts; Brent Richards; Jeffrey Lipman // Journal of Antimicrobial Chemotherapy (JAC);Feb2007, Vol. 59 Issue 2, p285 

    Objectives: To compare the clinical and bacteriological outcome of critically ill patients with sepsis treated by ceftriaxone administered as a once-a-day intermittent bolus dose or by 24 h continuous infusion. Patients and methods: We conducted an open-label, randomized...

  • Soluble Urokinase Plasminogen Activator Receptor as a Marker for Use of Antidepressants. Haastrup, Eva; Grau, Katrine; Eugen-Olsen, Jesper; Thorball, Christian; Kessing, Lars Vedel; Ullum, Henrik // PLoS ONE;Oct2014, Vol. 9 Issue 10, p1 

    Objectives: Inflammation is involved in the pathogenesis of depression. A few cross-sectional population-based studies have found that depression is associated with increased levels of inflammatory markers. Soluble urokinase plasminogen activation receptor (suPAR) is known to be a stable marker...

  • Sequential evaluation of prognostic models in the early diagnosis of acute kidney injury in the intensive care unit. e Silva, Verônica Torres Costa; de Castro, Isac; Liaño, Fernando; Muriel, Alfonso; Rodríguez-Palomares, Jose R.; Yu, Luis // Kidney International;May2009, Vol. 75 Issue 9, p982 

    General and specific severity scores for patients with acute kidney injury have significant limitations due in part to the diversity of methods that have been used. Here we prospectively validated five general (APACHE II, SAPS II, SOFA, LODS, and OSF) and three specific (SHARF, Liaño, and...

  • Central venous blood culture: a useful test for catheter colonisation? Juste, R. N.; Hannan, M.; Glendenning, A.; Azadian, B.; Soni, N. // Intensive Care Medicine;Sep2000, Vol. 26 Issue 9, p1373 

    Objective: To evaluate the widespread practice of using qualitative culture of venous blood taken through central venous catheters (CVCs) as a means of diagnosing catheter colonisation in situ.Design: A prospective clinical study.Patients: Three hundred...

  • Procalcitonin as a marker of the systemic inflammatory response to infection. Reinhart, K.; Karzai, W.; Meisner, M. // Intensive Care Medicine;Sep2000, Vol. 26 Issue 9, p1193 

    Examines the use of procalcitonin as a possible marker of the systemic inflammatory response to infection. Biology of procalcitonin; Relation between the increase in procalcitonin levels and severity of inflammatory response to infection; Usability of procalcitonin in identifying an infectious...

  • An evaluation of systemic inflammatory response syndrome signs in the Sepsis Occurrence In Acutely Ill Patients (SOAP) study. Sprung, Charles L.; Sakr, Yasser; Vincent, Jean-Louis; Le Gall, Jean-Roger; Reinhart, Konrad; Ranieri, V. Marco; Gerlach, Herwig; Fielden, Jonathan; Groba, C. B.; Payen, Didier // Intensive Care Medicine;Mar2006, Vol. 32 Issue 3, p421 

    Objective: To define the frequency and prognostic implications of SIRS criteria in critically ill patients hospitalized in European ICUs.Design and Setting: Cohort, multicentre, observational study of 198 ICUs in 24 European countries.Patients and Interventions:...

  • Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort study. Alberti, Corinne; Brun-Buisson, Christian; Burchardi, Hilmar; Martin, Claudio; Goodman, Sergey; Artigas, Antonio; Sicignano, Alberto; Palazzo, Mark; Moreno, Rui; Boulmé, Ronan; Lepage, Eric; Le Gall, Jean Roger // Intensive Care Medicine;Feb2002, Vol. 28 Issue 2, p108 

    Objectives: To examine the incidence of infections and to describe them and their outcome in intensive care unit (ICU) patients. Design and setting: International prospective cohort study in which all patients admitted to the 28 participating units in eight countries between May 1997 and May...

  • Presepsin (soluble CD14 subtype) and procalcitonin levels for mortality prediction in sepsis: data from the Albumin Italian Outcome Sepsis trial. Masson, Serge; Caironi, Pietro; Spanuth, Eberhard; Thomae, Ralf; Panigada, Mauro; Sangiorgi, Gabriela; Fumagalli, Roberto; Mauri, Tommaso; Isgrò, Stefano; Fanizza, Caterina; Romero, Marilena; Tognoni, Gianni; Latini, Roberto; Gattinoni, Luciano // Critical Care;2014, Vol. 18 Issue 1, p1 

    Introduction Sepsis, a leading cause of death in critically ill patients, is the result of complex interactions between the infecting microorganisms and the host responses that influence clinical outcomes. We evaluated the prognostic value of presepsin (sCD14-ST), a novel biomarker of bacterial...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics