TITLE

Facilitation of pancreatic duct cannulation using a new synthetic porcine secretin

AUTHOR(S)
Devereaux, Benedict M.; Lehman, Glen A.; Fein, Seymour; Phillips, Susan; Fogel, Evan L.; Sherman, Stuart
PUB. DATE
September 2002
SOURCE
American Journal of Gastroenterology (Springer Nature);Sep2002, Vol. 97 Issue 9, p2279
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVES:Cannulation of the pancreatic duct at ERCP can represent a technical challenge, even to experienced pancreaticobiliary endoscopists. Secretin is a polypeptide hormone that increases the volume and bicarbonate content of pancreatic secretions. We report our single center experience in the use of a new synthetic porcine secretin (sPS) for the facilitation of cannulation of either the major or minor pancreatic orifice during ERCP.METHODS:Patients presenting for a variety of indications were enrolled. If identification or cannulation of the desired pancreatic duct was difficult, 0.2 μg/kg of sPS was administered i.v. Cannulation success or failure was recorded.RESULTS:Between March, 1999, and May, 2000, a total of 25 patients (seven men and 18 women) were enrolled. The most frequent indication (15 of 25 cases) was facilitation of dorsal pancreatic duct cannulation in patients with pancreas divisum. The overall rate of successful cannulation secretin administration was 24 of 25 cases (96%). No adverse events directly attributable to secretin were observed.CONCLUSIONS:The results of this study show that sPS is safe and efficacious in faciliting cannulation of either the major or minor pancreatic orifice at ERCP in the subset of patients who represent cannulation difficulties. Once commercially available, sPS can be added to the armamentarium of techniques to facilitate ERP.
ACCESSION #
7885914

 

Related Articles

  • Proteomic analysis of pancreatic juice for the identification of biomarkers of pancreatic cancer. Park, Jeong; Kim, Sun-A; Chung, Joo; Bang, Seungmin; Park, Seung; Paik, Young-Ki; Song, Si // Journal of Cancer Research & Clinical Oncology;Aug2011, Vol. 137 Issue 8, p1229 

    Introduction: Protein profiles of endoscopically collected pancreatic juice from normal, chronic pancreatitis patients and pancreatic cancer patients were compared to identify diagnostic biomarkers of pancreatic cancer. Methods: Secretin was injected intravenously and pancreatic juice was...

  • Physiological increase in plasma leptin markedly inhibits insulin secretion in vivo. Cases, Jane A.; Gabriely, Ilan; Ma, Xiao Hui; Yang, Xiao Man; Michaeli, Tamar; Fleischer, Norman; Rossetti, Luciano; Barzilai, Nir; Cases, J A; Gabriely, I; Ma, X H; Yang, X M; Michaeli, T; Fleischer, N; Rossetti, L; Barzilai, N // Diabetes;Feb2001, Vol. 50 Issue 2, p348 

    The demonstration of leptin receptors on the pancreatic beta-cells suggests the possibility of direct actions of leptin on insulin secretion. In vitro studies on islets or perfused pancreas and beta-cell lines produced inconsistent results. We performed an in vivo study to distinctly examine...

  • Pancreatic Excretion Test and Barrier Hypothesis in Progression of Chronic Pancreatitis. Noda, Aiji; Hayakawa, Tetsuo; Horiguchi, Yuji; Naruse, Satoru; Iinuma, Yukio // American Journal of Gastroenterology;Jun1978, Vol. 69 Issue 6, p673 

    Simultaneous data of the pancreozymin-secretin test and the pancreatic excretion test with 5,5-dimethyl-2,4-oxazolidinedione (DMO) were reported for 50 patients with chronic pancreatitis. The pancreozymin-secretin test was abnormal in 90% of the patients, while the pancreatic DMO excretion test...

  • Amylin is associated with delayed gastric emptying in critically ill children. Mayer, Anton-Paul T.; Durward, Andrew; Turner, Charles; Skellett, Sophie; Dalton, Neil; Tibby, Shane M.; Murdoch, Ian A. // Intensive Care Medicine;Mar2002, Vol. 28 Issue 3, p336 

    Objectives: Amylin is a novel 37 amino acid that is secreted together with insulin from the pancreas in response to enteral nutrient intake. As a potent inhibitor of gastric motility it plays an important role in the control of carbohydrate absorption. In this study we aimed to determine the...

  • When a domain is not a domain. Park, Sang Youn; Shoelson, Steven E. // Nature Structural & Molecular Biology;Mar2008, Vol. 15 Issue 3, p224 

    The article provides information on the kinase regulatory-loop binding (KRLB). KRLB was once considered as a domain that has adhering properties analogous to phosphotyrosine binding (PTB) domains. However, a study showed that KLRB is a short peptide segment that conjugates to insulin receptor to...

  • Glucagon-like peptide 2 (GLP-2) accelerates the growth of colonic neoplasms in mice. Thulesen, J.; Hartmann, B.; Hare, K. .J.; Kissow, H.; Ørskov, C.; Holst, J. J.; Poulsen, S. S. // Gut;Aug2004, Vol. 53 Issue 8, p1145 

    Background: Glucagon-like peptide 2 (GLP-2) is an intestinotrophic mediator with therapeutic potential in conditions with compromised intestinal capacity. However, growth stimulation of the intestinal system may accelerate the growth of existing neoplasms in the intestine. Aims: In the present...

  • Increased intracellular content of enteroglucagon in proximal colon is related to intestinal adaptation to germ-free status. Arantes, R. M. E.; Nogueira, A. M. M. F. // Cell & Tissue Research;Mar2001, Vol. 303 Issue 3, p447 

    Changes in the frequency of endocrine cells are evidence of intestinal adaptation to germ-free (GF) status. Not only the distribution of these cells along the intestine, but also the differences in intracellular content of these regulatory peptides may be explored to explain functional and...

  • Glucagon attenuates the action of insulin on glucose output in the liver of the Goto-Kakizaki rat perfused in situ. Doi, Yasuko; Iwai, Masaru; Matsuura, Bunzou; Onji, Morikazu // Pflugers Archiv European Journal of Physiology;Jul2001, Vol. 442 Issue 4, p537 

    The effects of glucagon and insulin on glucose production were explored directly using the isolated perfused liver of the Goto-Kakizaki (GK) rat, an animal model of type-2 diabetes. In the perfused liver of control rats, infusion of glucagon (0.06–1.0 nM) into the portal vein...

  • Characterisation of gastric ghrelin cells in man and other mammals: studies in adult and fetal tissues. Rindi, Guido; Necchi, Vittorio; Savio, Antonella; Torsello, Antonio; Zoli, Michele; Locatelli, Vittorio; Raimondo, Francesca; Cocchi, Daniela; Solcia, Enrico // Histochemistry & Cell Biology;Jun2002, Vol. 117 Issue 6, p511 

    Ghrelin is a new gastric peptide involved in food intake control and growth hormone release. We aimed to assess its cell localisation in man during adult and fetal life and to clarify present interspecies inconsistencies of gastric endocrine cell types. A specific serum generated against amino...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics