TITLE

Early intervention with a small molecule inhibitor for tumor necrosis factor-α prevents cognitive deficits in a triple transgenic mouse model of Alzheimer's disease

PUB. DATE
January 2012
SOURCE
Journal of Neuroinflammation;2012, Vol. 9 Issue 1, p99
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article presents a study which examines the effects of early immune modulation on neuroinflammation and cognitive outcomes in a transgenic mouse model of Alzheimer's disease. Two small molecule tumor necrosis factor-alpha inhibitors are highlighted which include 3,6'-dithiothalidomide and thalidomide. The effectiveness of 3,6'-dithiothalidomide in improving the working memory performance is outlined.
ACCESSION #
78319115

 

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