Rasburicase for Huge Hepatocellular Carcinoma with Tumor Lysis Syndrome: Case Report

Chao, Chia-Ter; Chiang, Chih-Kang
July 2012
Medical Principles & Practice;Jul2012, Vol. 21 Issue 5, p498
Academic Journal
Objective: To report a case of huge hepatocellular carcinoma associated with tumor lysis syndrome and its management. Clinical Presentation and Intervention: A 51-year-old hepatitis B carrier visited our clinic with progressive weight loss over recent months. Abdominal ultrasonography and magnetic resonance imaging revealed a huge hepatic mass in a cirrhotic liver, identified as hepatocellular carcinoma. A hepatologist and surgeon recommended transarterial chemoembolization followed by hepatectomy. The patient underwent the procedure, with the complication of tumor lysis syndrome. He was treated with a single high dose (9 mg) of rasburicase and his clinical condition improved dramatically, with acute kidney injury subsiding without emergent hemodialysis. Conclusions: This was a case of hepatocellular carcinoma with tumor lysis syndrome and acute kidney injury, treated successfully with rasburicase. Copyright © 2012 S. Karger AG, Basel


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